A5083484613- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Hepatitis C virus research
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Inflammatory Bowel Disease
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Diet and metabolism studies
- Systemic Lupus Erythematosus Research
- Liver Diseases and Immunity
- Animal Virus Infections Studies
- Celiac Disease Research and Management
- Dysphagia Assessment and Management
- Diverticular Disease and Complications
- Digestive system and related health
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Screening and Detection
University of Pisa
2014-2023
Ospedale Cisanello
2018
Azienda Ospedaliera Universitaria Pisana
2018
University of Genoa
2016
Medical University of Lodz
2016
University of Padua
2016
Italian Association for Cancer Research
2015
University Hospital of Bern
2015
De Agostini (Italy)
2015
University of Modena and Reggio Emilia
2009
Abstract Background Recently, it has been suggested that low esophageal basal impedance may reflect impaired mucosal integrity and increased acid sensitivity. We aimed to compare baseline levels in patients with heartburn pathophysiological characteristics related functional ( FH ) divided into two groups on the basis of symptom relief after proton pump inhibitors PPI s). Methods Patients negative endoscopy were treated esomeprazole or pantoprazole 40 mg daily for 8 weeks. According MII‐pH...
ABSTRACT The natural history and pathogenic potential of the recently identified TT virus (TTV) are currently a matter intensive investigation. In an attempt to shed some light on these issues, nasal blood specimens 1- 24-month-old children hospitalized with clinical diagnosis acute respiratory disease (ARD) were examined for presence, load, genetic characteristics TTV. results have indicated that at least in young children, tract not only represents route by which abundant TTV can be into...
Barrett's esophagus (BE) is a premalignant condition for which regular endoscopic follow-up usually advised. We evaluated the incidence of esophageal adenocarcinoma (AC) in patients with BE and impact surveillance on mortality from AC.A cohort newly diagnosed was studied prospectively. Endoscopic histological recommended every 2 yr. Follow-up status determined hospital registry office records telephone calls to patients.From 1987 1997, 177 patients. excluded three high-grade dysplasia (HGD)...
On-therapy impedance-pH monitoring in proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) yielded conflicting results. We aimed to assess the diagnostic value of postreflux swallow-induced peristaltic wave (PSPW) index and mean nocturnal baseline impedance (MNBI) PPI-refractory heartburn.On-therapy tracings from 189 consecutive patients with heartburn were blindly reviewed. Patients subdivided into refractory esophagitis (RRE), healed (HRE), non-erosive (NERD),...
Acid exposure time (AET) is considered the most useful parameter to predict response of reflux-related heartburn medical or surgical treatment. However, recent studies showed high rates proton pump inhibitor (PPI) therapy in patients with normal AET. We aimed compare efficacy postreflux swallow-induced peristaltic wave (PSPW) index and mean nocturnal baseline impedance (MNBI) AET linking PPI-responsive reflux.Off-therapy impedance-pH tracings from 425 patients, 317 108 PPI-refractory were...
<h3>Objective</h3> IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true risk factors by means of genome-wide association (GWA) and independent replication studies. <h3>Design</h3> conducted a GWA study (GWAS) in general population sample 11 326 Swedish twins. cases (N=534) asymptomatic controls (N=4932) were identified based on questionnaire data. Suggestive signals followed-up 3511 individuals from six case-control...
High-resolution manometry (HRM) provides information on esophagogastric junction (EGJ) morphology, distinguishing three different subtypes. Data the correlation between EGJ subtypes and impedance-pH detected reflux patterns are lacking. We aimed to correlate with findings in patients symptoms.Consecutive suspected gastroesophageal disease (GERD) were enrolled. All underwent HRM testing off-therapy. was classified as: Type I, no separation lower esophageal sphincter (LES) crural diaphragm...
Background and Aims . By means of 24 h impedance-pH monitoring, we aimed to evaluate the effect two different meals with a bromatological balanced composition: one prevailing component animal proteins other vegetable proteins. Patients Methods We enrolled 165 patients heartburn negative endoscopy, who underwent monitoring off therapy. were allocated receive Mediterranean diet total caloric intake about 1694 kcal, divided into meals: evaluated reflux number, acid exposure time (AET),...
Abstract Barrett's esophagus (BE) is an acquired disorder due to chronic gastroesophageal reflux. Environmental factors seem play important role in the pathogenesis of BE, especially Western society. A multicenter case‐control study was carried out between February 1995 and April 1999 8 Italian Departments Gastroenterology gathered a group (GOSPE), order analyze influence some individual characteristics life‐style habits on occurrence BE. Three groups patients were studied: 149 with 143...
OBJECTIVES Helicobacter pylori is causally associated with gastritis and peptic ulcer diseases. Recent data (meta-analysis) have demonstrated that triple therapy amoxicillin, clarithromycin, a proton pump inhibitor has an eradication rate of only 74–76% new therapeutic protocols may be necessary. The aim this study was to examine whether adding bovine lactoferrin (bLf) probiotics (Pbs) the standard for H. infection could improve reduce side effects. METHODS diagnosed in 206 patients: 107...
Laryngopharyngeal reflux is defined as the of gastric content into larynx and pharynx. A large number data suggest growing prevalence laryngopharyngeal symptoms in patients with gastroesophageal disease. However, a multifactorial syndrome disease not only cause involved its pathogenesis. Current critical issues diagnosing are many nonspecific laryngeal signs, poor sensitivity specificity all currently available diagnostic tests. Although it pragmatic clinical strategy to start empiric trials...
Irritable bowel syndrome (IBS), a common functional gastrointestinal disorder, is classified according to habits as IBS with constipation (IBS-C), diarrhea (IBS-D), alternating and (IBS-M), unsubtyped (IBS-U). The mechanisms leading the different forms are mostly unknown. This study aims evaluate whether specific fecal bacterial taxa and/or short-chain fatty acids (SCFAs) can be used distinguish subtypes relevant for explaining clinical differences between subcategories. We characterized...
Abstract Background A short‐course of proton pump inhibitors ( PPI s) is often used to confirm gastroesophageal reflux disease GERD ). However, some patients with responsive heartburn do not seem have evidence on impedance‐pH monitoring (MII‐pH). The aim the study was evaluate symptoms and a negative endoscopy, who well respond s MII‐pH. Methods We enrolled 312 endoscopy: 144 reported well‐controlled after 8‐week 155 were non‐responders. Symptom relief evaluated Impact Scale visual analog...
Summary Background Gastro‐oesophageal reflux disease (GERD) may contribute to the onset of chronic cough (CC); however, multichannel intraluminal impedance‐pH (MII‐pH) monitoring is often within normal range and response proton pump inhibitors (PPIs) unsatisfactory. The measure impedance baseline (IB) increases sensitivity MII‐pH in patients with typical symptoms. Aim To evaluate role variables, including IB, predicting PPI define characteristics pattern CC patients. Methods Prospectively...