A5058810947- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Urticaria and Related Conditions
- Glycosylation and Glycoproteins Research
- Surgical Sutures and Adhesives
- Sphingolipid Metabolism and Signaling
- Colorectal Cancer Treatments and Studies
- Adenosine and Purinergic Signaling
- Cutaneous lymphoproliferative disorders research
- Monoclonal and Polyclonal Antibodies Research
- Estrogen and related hormone effects
- Bone Metabolism and Diseases
- Tryptophan and brain disorders
- Quinazolinone synthesis and applications
- Contact Dermatitis and Allergies
- NF-κB Signaling Pathways
- Calcium signaling and nucleotide metabolism
- Transgenic Plants and Applications
- Advancements in Transdermal Drug Delivery
- Complement system in diseases
University Hospital Bonn
2020-2024
CK-CARE
2020-2023
University of Bonn
2011-2018
University of Göttingen
2007-2014
The heterogeneous (endo)phenotypes of atopic dermatitis (AD) require precision medicine. Currently, systemic therapy is recommended to patients with an Eczema Area and Severity Index (EASI)≥16. Previous studies have demonstrated improved treatment response the anti-interleukin (IL)-13 antibody tralokinumab in AD subgroups elevated levels IL-13-related biomarkers dipeptidyl-peptidase (DPP)-4 periostin.
Abstract Background Autoreactive immunoglobulin E (IgE) antibodies to self‐peptides within the epidermis have been identified in patients with atopic dermatitis (AD). Prevalence, concomitant diseases, patient characteristics, and risk factors of IgE autoantibody development remain elusive. We aimed determine autoantibodies serum samples ( n = 672) from well‐characterized AD controls (1.2–88.9 years). Methods Atopic were sub‐grouped comorbid Type‐2 diseases (“AD + Type 2”; asthma, allergic...
Abstract Background The skin of atopic dermatitis ( AD ) patients presents a significant dysbalance the microbiome with high colonization by Staphylococcus aureus S. ), which positively correlates severity disease. Objective Understanding role epidermal dendritic cells (DC) as link between innate and adaptive immune systems in . Methods Comparative phenotypic functional analysis TLR 2 on Langerhans LC inflammatory IDEC organotypic models well freshly isolated from healthy skin. Results In...
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and driven by a complex pathophysiology underlying highly heterogeneous phenotypes. Current advances in precision medicine emphasize need for stratification.To perform deep phenotyping identification of severity-associated factors adolescent adult patients with AD.Cross-sectional data from baseline visit prospective longitudinal study investigating phenotype among inpatients outpatients AD Department Dermatology...
Atopic dermatitis (AD) has long been regarded as a primarily pediatric disease. However, there is growing evidence for high rate of adult-onset AD. We aimed to characterize factors associated with versus childhood-onset AD and controls.We analyzed cross-sectional data the CK-CARE-ProRaD cohorts Bonn, Augsburg, Davos, Zürich 736 adult patients stratified by age onset (childhood-onset <18 years: 76.4% (subsets: 0 2; ≥2 6; ≥7 11; ≥12 18); ≥18 23.6% 40; ≥41 60; ≥61) 167 controls (91 atopic, 76...
Abstract Background Aryl hydrocarbon receptor (AhR), an important regulator of immune responses, is activated by UVB irradiation in the skin. Langerhans cells ( LC ) epidermis patients with atopic dermatitis AD carry high‐affinity for IgE, Fcε RI , and are crucially involved pathogenesis inducing inflammatory responses regulating tolerogenic processes. Objectives We investigated AhR repressor (Ah RR expression functional consequences activation human ex vivo skin vitro ‐generated . Methods...
Optimal B cell activation requires the recruitment of a vesicle-associated adaptor protein to receptor complex.
Abstract Background Atopic dermatitis (AD) and psoriasis vulgaris (PV) are almost mutually exclusive diseases with different immune polarizations, mechanisms therapeutic targets. Switches to the other disease (“Flip‐Flop” [FF] phenomenon) can occur or without systemic treatment often referred as paradoxical reactions under biological therapy. Methods The objective was develop a diagnostic algorithm by combining clinical criteria of AD PV identify FF patients. prospectively validated in...
Epidermal Langerhans cells (LC) expressing the high-affinity receptor for IgE (FcεRI) play a key role in atopic dermatitis (AD). AD skin is highly colonized with Staphylococcus aureus (S.a.), which are sensed by Toll-like 2 (TLR2). We hypothesized that TLR2 may impact on expression of FcεRI LC.To study putative signaling FcεRI, we analyzed and known transcription factors after ligand binding to TLR2.We generated LC from CD34(+) progenitors vitro (CD34LC) as well its partners TLR1 TLR6. The...
The family of SLPs (Src homology 2 domain-containing leukocyte adaptor proteins) are cytoplasmic signal effectors lymphocyte antigen receptors. A main function SLP is to orchestrate the assembly Ca(2+)-mobilizing enzymes at inner leaflet plasma membrane. For this purpose, SLP-76 in T cells utilizes transmembrane LAT, but mechanism SLP-65 membrane anchoring B remains an enigma. We now employed two genetic reconstitution systems unravel structural requirements for initiation Ca(2+)...
Circulating phospholipids have been considered as biomarkers and therapeutic targets in multiple disorders. Atopic dermatitis (AD) is the most common inflammatory skin disease. Although there are numerous studies having addressed stratum corneum lipids context of epidermal barrier, little known about circulating patients with AD. In this study, we explored changes serum AD using liquid chromatography coupled to tandem mass spectrometry sought lipids' contribution clinical status. Several...
Abstract Atopic dermatitis (AD) is a severe inflammatory skin disease. Langerhans cells and dendritic epidermal (IDEC) are located in the epidermis of AD patients contribute to processes. Both express robustly high-affinity receptor for IgE, FcεRI, thereby sense allergens. A beneficial role vitamin D3 discussed be important especially with allergic sensitization. We hypothesized that impacts FcεRI expression addressed this human ex vivo skin, vitro cells, IDEC models generated from primary...
Aim: The 4th Davos Declaration, convened during the Global Allergy Forum (GAF) in Davos, aimed to elevate patient care for patients with atopic dermatitis (AD) by uniting experts and stakeholders. forum addressed high prevalence of AD, a strategic focus on advancing research, treatment, management meet evolving challenges field. Methods: This multidisciplinary brought together top leaders from clinical practice, policy, advocacy discuss critical aspects including neuroimmunology,...
Background: There is contradictory evidence on the association between atopic dermatitis (AD) and cardiovascular comorbidities.The aim of this study was thus to further explore connection how it relates presence comorbidities.
Patients suffering from atopic dermatitis (AD) show an attenuated immune response and imbalanced microbiome environment that favors Staphylococcus aureus (S. aureus).1 Bacterial products are recognized via Toll-like receptors (TLR) of the system leading to maturation dendritic cells (DC).2 Recently, we showed Langerhans (LC), DC in epidermis, ex vivo AD skin had inhibited toward TLR2 stimulation when compared healthy controls (HC).3 Topical anti-inflammatory treatment reduces inflammation...
// Sarah Kemski 1 , 2 Vivien Molitor Michael Steffens Tim J. Nümm Nadine Herrmann Thorsten Hornung Thomas Bieber Christian Schumann 3 Volker Kächele 4 Seufferlein 5 Heinemann 6 Catharina Scholl and Julia Carolin Stingl 7 Research Division, Federal Institute for Drugs Medical Devices (BfArM), Bonn, Germany Department of Dermatology Allergy, Christine Kühne Center Allergy Education (CK-CARE), University Hospital-Bonn, Pulmonology, Thorax Oncology, Sleep Respiration...