A5082205135- Asthma and respiratory diseases
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Allergic Rhinitis and Sensitization
- Fatty Acid Research and Health
- Crystallography and molecular interactions
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Clinical Nutrition and Gastroenterology
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Diet and metabolism studies
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Eosinophilic Esophagitis
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Sinusitis and nasal conditions
- Antimicrobial Peptides and Activities
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cytokine Signaling Pathways and Interactions
- Adipokines, Inflammation, and Metabolic Diseases
- Signaling Pathways in Disease
University of Zurich
2016-2025
University Hospital of Zurich
2019-2025
University Children's Hospital Zurich
2019-2023
CK-CARE
2015-2021
Institute for Asthma and Allergy
2020
University of Mississippi Medical Center
2020
State Street (United States)
2020
American College of Allergy, Asthma and Immunology
2020
University Hospital of Basel
2019
University Hospital of Bern
2019
Morbidity and mortality from COVID-19 caused by novel coronavirus SARS-CoV-2 is accelerating worldwide, clinical presentations of are often reported. The range human cells tissues targeted SARS-CoV-2, its potential receptors associated regulating factors still largely unknown. aim our study was to analyze the expression known related molecules in extensive collection primary healthy subjects different age patients with risk comorbidities COVID-19.We performed RNA sequencing explored...
BackgroundTight junction (TJ) defects have recently been associated with asthma and chronic rhinosinusitis. The expression, function, regulation of nasal epithelial TJs remain unknown in patients allergic rhinitis (AR).ObjectiveWe investigated the epithelium house dust mite (HDM)–induced AR an HDM-induced murine model airway disease.MethodsAir-liquid interface cultures primary cells control subjects were used for measuring transepithelial resistance passage to fluorescein...
BackgroundAllergic rhinitis (AR) is characterized by mucosal inflammation, driven activated immune cells. Mast cells and TH2 might decrease epithelial barrier integrity in AR, maintaining a leaky barrier.ObjectiveWe sought to investigate the role of histamine driving dysfunction AR.MethodsAir-liquid interface cultures primary nasal were used measure transepithelial electrical resistance, paracellular flux fluorescein isothiocyanate-dextran 4 kDa, mRNA expression tight junctions. Nasal...
Abstract Rhinoviruses and allergens, such as house dust mite are major agents responsible for asthma exacerbations. The influence of pre-existing airway inflammation on the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely unknown. We analyse mechanisms response to viral in experimental vivo rhinovirus healthy controls patients asthma, vitro experiments mite, SARS-CoV-2 human primary epithelium. Here, we show that leads an excessive RIG-I inflammasome...
Respiratory syncytial virus (RSV) is an important risk factor of asthma development and responsible for severe respiratory tract infections. However, the influence RSV infection on barrier function bronchial epithelial cells in vitro vivo still unclear. The aim this study was to analyse role tight junction (TJ) regulation compare integrity between asthmatic healthy individuals upon infection. Healthy human (HBECs) were differentiated at air-liquid interface (ALI) infected with ultraviolet...
Abstract Background Many skin and mucosal inflammatory disorders, such as atopic dermatitis, have been associated with an impaired epithelial barrier function, which allows allergens, pollutants, or microbes to enter the tissue activate immune response. The aim of this study was establish a method directly assess in vivo epidermal function by electrical impedance (EI) spectroscopy. Methods Mice damaged epicutaneous application proteases cholera toxin tape stripping. EI transepidermal water...
Abstract Asthma is a heterologous disease that influenced by complex interactions between multiple environmental exposures, metabolism, and host immunoregulatory processes. Specific metabolites are increasingly recognized to influence respiratory inflammation. However, the role of protein‐derived in regulating inflammatory responses lung poorly described. The aims present study were quantify polyamine levels bronchoalveolar lavages (BALs) from healthy volunteers asthma patients, evaluate...
Fatty acids and lipid mediator signaling play an important role in the pathogenesis of asthma, yet this area remains largely underexplored. The aims study were (i) to examine fatty acid levels their metabolism obese nonobese asthma patients (ii) determine functional effects altered experimental models.Medium- long-chain quantified serum from 161 human volunteers by LC/MS. Changes stearoyl-coenzyme A desaturase (SCD) expression activity evaluated ovalbumin (OVA) house dust mite (HDM) murine...