A5076807569- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Parathyroid Disorders and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Disorders and Syndromes
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Pediatric health and respiratory diseases
- Contact Dermatitis and Allergies
- Child Nutrition and Feeding Issues
- Magnesium in Health and Disease
- Lipoproteins and Cardiovascular Health
- Cardiac electrophysiology and arrhythmias
- Fibroblast Growth Factor Research
- Infant Nutrition and Health
- Pregnancy and preeclampsia studies
National Center For Child Health and Development
2016-2025
Osaka University of Pharmaceutical Sciences
2021-2025
National Institute of Technology, Oyama College
2024
Osaka Medical and Pharmaceutical University
2012-2023
Center for Children
2023
University of Zurich
2014-2021
Keio University
2009-2021
CK-CARE
2015-2020
Hokkaido University
1989-2020
Seoul National University Hospital
2013
IL-33, a member of the IL-1-related cytokines, is considered to be proallergic cytokine that especially involved in Th2-type immune responses. Moreover, like IL-1α, IL-33 has been suggested act as an “alarmin” amplifies responses during tissue injury. In contrast IL-1, however, precise roles those settings are poorly understood. Using IL-1- and IL-33-deficient mice, we found but not played substantial role induction T cell-mediated type IV hypersensitivity such contact delayed-type...
BackgroundRecent studies have suggested that epidermal barrier dysfunction contributes to the development of atopic dermatitis (AD) and other allergic diseases.ObjectiveWe performed a prospective, randomized controlled trial investigate whether protecting skin with moisturizer during neonatal period prevents AD sensitization.MethodsAn emulsion-type was applied daily first 32 weeks life 59 118 neonates at high risk for (based on having parent or sibling AD) who were enrolled in this study....
Morbidity and mortality from COVID-19 caused by novel coronavirus SARS-CoV-2 is accelerating worldwide, clinical presentations of are often reported. The range human cells tissues targeted SARS-CoV-2, its potential receptors associated regulating factors still largely unknown. aim our study was to analyze the expression known related molecules in extensive collection primary healthy subjects different age patients with risk comorbidities COVID-19.We performed RNA sequencing explored...
Abstract Group 2 innate lymphoid cells (ILC2s) are involved in human diseases, such as allergy, atopic dermatitis and nasal polyposis, but their function cancer remains unclear. Here we show that, acute promyelocytic leukaemia (APL), ILC2s increased hyper-activated through the interaction of CRTH2 NKp30 with elevated tumour-derived PGD2 B7H6, respectively. ILC2s, turn, activate monocytic myeloid-derived suppressor (M-MDSCs) via IL-13 secretion. Upon treating APL all-trans retinoic acid...
Cytokines employ downstream Janus kinases (JAKs) to promote chronic inflammatory diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with JAK1 gain-of-function (GoF) variants develop atopic dermatitis (AD) asthma. To explore tissue-specific functions, we inserted a human GoF variant (JAK1GoF) into mice observed the development of spontaneous AD-like skin disease but unexpected resistance lung inflammation when JAK1GoF expression was restricted stroma. We...
IL-33 is a member of the IL-1 family and mediates its biological effects via ST2 receptor, which selectively expressed on Th2 cells mast cells. Although polymorphic variation in strongly associated with asthma, it currently unclear whether acts directly lung tissue at sites airway remodeling. Therefore, we aimed to identify IL-33-responsive among primary human mRNA was both endothelial epithelial but not fibroblasts or smooth muscle Correspondingly, promoted IL-8 production by Transfection...
Background— In heart failure (HF), aldosterone has been implicated in the formation of reactive interstitial fibrosis, a maladaptation that contributes to left ventricular (LV) remodeling. Eplerenone is novel selective blocker. The present study examined effects long-term monotherapy with eplerenone on progression LV dysfunction and remodeling dogs chronic HF. Methods Results— HF was produced 14 by intracoronary microembolizations were discontinued when ejection fraction (EF) between 30%...
BackgroundDespite the efficacy of allergen-specific immunotherapy (AIT), role trained immunity and tolerance in this process has not been elucidated.ObjectiveHere, we have performed a comprehensive longitudinal analysis systemic innate immune cell repertoire during course AIT.MethodsPatients with allergy received standard preseasonal subcutaneous AIT allergoids to birch and/or grass. Healthy controls were monitored without any intervention. Flow cytometry lymphoid (ILC), natural killer cell,...
Epidemiological studies demonstrated that cleaning work and frequent use of products are risk factors for asthma. Laundry detergents have been reported to epithelial barrier-opening effects. However, whether laundry directly induce airway inflammation its mechanisms in vivo remain be elucidated.Two commercial two commonly used surfactants cosmetics (sodium lauryl sulfate sodium dodecyl benzene sulfonate) were intranasally administered mice. Lungs analyzed using flow cytometry, histology,...
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy with gastrointestinal symptoms such as vomiting and diarrhea. The development of international consensus guidelines for the diagnosis management FPIES in 2017 enabled us to compare patients worldwide, regardless geographic variation disease features. As result, it has become clear that there heterogeneity among or are cases partly fit diagnostic criteria but have different characteristics. This review...
The present study assesses whether ranolazine increases left ventricular (LV) function without an increase in myocardial oxygen consumption (MV̇ o 2 ) and thus improves LV mechanical efficiency dogs with heart failure (HF). Ranolazine did not change MV̇ increased (22.4±2.8% to 30.9±3.4% ( P <0.05). In contrast, dobutamine significantly improve efficiency. Thus, short-term treatment improved , resulting HF.