A5044942485- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Amyotrophic Lateral Sclerosis Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- HIV Research and Treatment
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Vitamin D Research Studies
- Advancements in Transdermal Drug Delivery
- T-cell and B-cell Immunology
- Multiple Sclerosis Research Studies
- Genetic Syndromes and Imprinting
- Whipple's Disease and Interleukins
- Electrical and Bioimpedance Tomography
- Cytokine Signaling Pathways and Interactions
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer Cells and Metastasis
- Geological and Tectonic Studies in Latin America
- RNA modifications and cancer
- Industrial Vision Systems and Defect Detection
University of Zurich
2016-2023
Istituto Superiore di Sanità
2013-2023
Fondazione IRCCS Istituto Nazionale dei Tumori
2022-2023
Memorial Ankara Hospital
2022
Koç University
2022
CK-CARE
2017-2022
AO Foundation
2022
Adnan Menderes University
2022
Institute for Asthma and Allergy
2020
University of Mississippi Medical Center
2020
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease with complex pathogenesis for which cellular and molecular crosstalk in AD has not been fully understood.Skin tissues examined spatial gene expression were derived from upper arm of 6 healthy control (HC) donors 7 patients (lesion nonlesion). We performed transcriptomics sequencing to characterize infiltrate lesional skin. For single-cell analysis, we analyzed data suction blister material lesions HC at antecubital...
Histamine is an important immunomodulator influencing both the innate and adaptive immune system. Certain host cells express histidine decarboxylase enzyme (HDC), which responsible for catalysing decarboxylation of to histamine. We others have shown that bacterial strains can also HDC secrete histamine; however, influence bacterial-derived histamine on responses distant gut unclear.The Escherichia coli BL21 (E BL21) strain was genetically modified Morganella morganii (M morganii)-derived...
Allergic disorders such as atopic dermatitis (AD) are strongly associated with an impairment of the epithelial barrier, in which tight junctions and/or filaggrin expression can be defective. Skin barrier assessment shows potential to clinically useful for prediction disease development, improved and earlier diagnosis, lesion follow-up, therapy evaluation. This study aimed establish a method directly assess vivo status using electrical impedance spectroscopy (EIS).Thirty-six patients AD were...
Abstract Background Many skin and mucosal inflammatory disorders, such as atopic dermatitis, have been associated with an impaired epithelial barrier function, which allows allergens, pollutants, or microbes to enter the tissue activate immune response. The aim of this study was establish a method directly assess in vivo epidermal function by electrical impedance (EI) spectroscopy. Methods Mice damaged epicutaneous application proteases cholera toxin tape stripping. EI transepidermal water...
Introduction Artificial Intelligence (AI) methods are being increasingly investigated as a means to generate predictive models applicable in the clinical practice. In this study, we developed model predict efficacy of immunotherapy (IO) patients with advanced non-small cell lung cancer (NSCLC) using eXplainable AI (XAI) Machine Learning (ML) methods. Methods We prospectively collected real-world data from an NSCLC condition receiving immune-checkpoint inhibitors (ICIs) either single agent or...
Abstract Background Epithelial barrier impairment is associated with many skin and mucosal inflammatory disorders. Laundry detergents have been demonstrated to affect epithelial function in vitro using air–liquid interface cultures of human cells. Methods Back C57BL/6 mice was treated two household laundry at several dilutions. Barrier assessed by electric impedance spectroscopy (EIS) transepidermal water loss (TEWL) measurements after the 4 h treatments detergents. RNA sequencing (RNA‐seq)...
Most epigenome-wide association studies to date have been conducted in blood. However, metabolic syndrome is mediated by a dysregulation of adiposity and therefore it critical study adipose tissue order understand the effects this on epigenomes. To determine if natural variation DNA methylation was associated with traits, we profiled global levels subcutaneous abdominal tissue. We measured between 32 clinical traits related diabetes obesity 201 people from Metabolic Syndrome Men cohort....
Abstract The “epithelial barrier hypothesis” proposes that genetic predisposition to epithelial damage, exposure various barrier–damaging agents and chronic periepithelial inflammation are responsible for the development of allergic autoimmune diseases. Particularly, introduction more than 200,000 new chemicals our daily lives since 1960s has played a major role in pandemic increase these constitutes first line physical, chemical, immunological defence against external factors. A leaky...
Vitamin D (vitD) low status is currently considered a main environmental factor in multiple sclerosis (MS) etiology and pathogenesis. VitD its metabolites are highly hydrophobic circulate mostly bound to the vitamin binding protein (DBP) with lower affinity albumin, while less than 1% free form. The aim of this study was investigate whether circulating levels either two vitD plasma carriers and/or their relationship altered MS. We measured DBP albumin 28 MS patients 24 healthy controls. were...
Macrophages are key targets of HIV-1 infection. We have previously described that the expression CC chemokine ligand 2 (CCL2) increases during monocyte differentiation to macrophages and it is further up-modulated by exposure. Moreover, CCL2 acts as an autocrine factor promotes viral replication in infected macrophages. In this study, we dissected molecular mechanisms which neutralization inhibits monocyte-derived (MDM), potential involvement innate restriction factors protein sterile alpha...
Earlier studies have suggested that the leukocyte redistribution can be considered as an immunological marker of clinical response to corticosteroids (CS), representing easy measurable potential biomarker in severe asthma.The aim this study was determinate utility a disease heterogeneity patients with asthma and bioindicator CS resistance.We developed unbiased clustering approach based on data flow cytometry results peripheral blood phenotypes 142 before after systemic administration.Based...
Chile se encuentra constantemente asediado por eventos de origen antrópico y natural que, en la mayoría los casos, devienen desastres o catástrofes que traen consigo pérdidas humanas materiales variada intensidad, cuyo costo combina con aquel asociado a sucesivos procesos reconstrucción deben ser implementados. Sin embargo no toda amenaza debe, necesariamente, conducir un desastre; es allí donde radica el principal aporte gestión del riesgo desastres, puede correctiva, reactiva prospectiva....
Allergic diseases include asthma, atopic-dermatitis, allergic-rhinitis, drug hypersensitivity and food-allergy. During the past years, there has been a global outbreak of allergic diseases, presenting considerable medical socioeconomical-burden. A large fraction is characterized by type-2 immune response involving Th2 cells, innate lymphoid eosinophils, mast M2 macrophages. Biomarkers are valuable parameters for precision medicine as they provide information on disease endotypes, clusters,...
In this review, we discuss recent publications on asthma and review the studies that have reported different aspects of prevalence, risk factors prevention, mechanisms, diagnosis treatment asthma. Many protective molecular mechanisms are involved in development Emerging concepts challenges implementing exposome paradigm its application allergic diseases reviewed, including genetic epigenetic factors, microbial dysbiosis environmental exposure, particularly to indoor outdoor substances. The...