A5037426265- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Eosinophilic Esophagitis
- Inflammasome and immune disorders
- Food Allergy and Anaphylaxis Research
- Cannabis and Cannabinoid Research
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Mast cells and histamine
- Inhalation and Respiratory Drug Delivery
- Exercise and Physiological Responses
- Gut microbiota and health
- Animal Virus Infections Studies
- Neonatal Respiratory Health Research
- SARS-CoV-2 and COVID-19 Research
- Cancer Cells and Metastasis
- Viral gastroenteritis research and epidemiology
- TGF-β signaling in diseases
- Helicobacter pylori-related gastroenterology studies
University of Zurich
2015-2024
CK-CARE
2014-2024
High dose bee venom exposure in beekeepers by natural stings represents a model to understand mechanisms of T cell tolerance allergens healthy individuals. Continuous nonallergic high doses antigens induces diminished cell–related cutaneous late-phase swelling parallel with suppressed allergen-specific proliferation and helper type 1 (Th1) Th2 cytokine secretion. After multiple stings, antigen–specific Th1 cells show switch toward interleukin (IL) 10–secreting regulatory (Tr1) cells....
Abstract FOXP3 is playing an essential role for T regulatory cells and involved in the molecular mechanisms controlling immune tolerance. Although biological relevance of this transcription factor well documented, pathways responsible its induction are still unclear. The current study reveals structure function human promoter, revealing induction. promoter was defined by RACE, cloned, functionally analyzed using reporter-gene constructs primary cells. analysis revealed basal, cell-specific...
Transcription factors act in concert to induce lineage commitment towards Th1, Th2, or T regulatory (Treg) cells, and their counter-regulatory mechanisms were shown be critical for polarization between Th1 Th2 phenotypes. FOXP3 is an essential transcription factor natural, thymus-derived (nTreg) inducible Treg (iTreg) commitment; however, the regulating its expression are as yet unknown. We describe a mechanism controlling iTreg polarization, which overruled by differentiation pathway....
Forkhead box P3 (FOXP3)+CD4+CD25+ inducible regulatory T (iT reg) cells play an important role in immune tolerance and homeostasis. In this study, we show that the transforming growth factor-β (TGF-β) induces expression of Runt-related transcription factors RUNX1 RUNX3 CD4+ cells. This induction seems to be a prerequisite for binding three putative RUNX sites FOXP3 promoter. Inactivation gene encoding cofactor core-binding (CBFβ) mice small interfering RNA (siRNA)-mediated suppression human...
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease with complex pathogenesis for which cellular and molecular crosstalk in AD has not been fully understood.Skin tissues examined spatial gene expression were derived from upper arm of 6 healthy control (HC) donors 7 patients (lesion nonlesion). We performed transcriptomics sequencing to characterize infiltrate lesional skin. For single-cell analysis, we analyzed data suction blister material lesions HC at antecubital...
The rising prevalence of many chronic diseases related to gut barrier dysfunction coincides with the increased global usage dietary emulsifiers in recent decades. We therefore investigated effect frequently used food on cytotoxicity, function, transcriptome alterations, and protein expression gastrointestinal epithelial cells.Human intestinal organoids originating from induced pluripotent stem cells, colon organoid organ-on-a-chip, liquid-liquid interface cells were cultured presence two...
Abstract Rhinoviruses and allergens, such as house dust mite are major agents responsible for asthma exacerbations. The influence of pre-existing airway inflammation on the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely unknown. We analyse mechanisms response to viral in experimental vivo rhinovirus healthy controls patients asthma, vitro experiments mite, SARS-CoV-2 human primary epithelium. Here, we show that leads an excessive RIG-I inflammasome...
Allergen-specific immunotherapy (AIT) is the only available treatment for allergic diseases that can induce specific immune tolerance to allergens. The key mechanisms involved in this process include changes allergen-specific regulatory T (Treg) cells.We studied 25 rhinitis patients undergoing subcutaneous house dust mite-specific immunotherapy. Peripheral blood mononuclear cells were before and after 10, 30 weeks, 3 years of AIT. Der p 1-specific cell responses investigated by...
There are no comprehensive surveys relating the reported high prevalence of asthma and allergic diseases in athletes to comorbidities immune changes associated with intense chronic exercise. This 12-year survey aims evaluate several clinical, functional immunological parameters order assess features, trend burden asthma, allergy, infections autoimmune diseases, a large homogeneous population Olympic athletes.Six hundred fifty-nine Italian were studied through four cross-sectional performed...
A novel B cell subset that produces proangiogenic cytokines is increased in pathologies associated with angiogenesis.