A5082517137- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- RNA and protein synthesis mechanisms
- Robot Manipulation and Learning
- Barrier Structure and Function Studies
- Viral-associated cancers and disorders
- Gear and Bearing Dynamics Analysis
- Protein Structure and Dynamics
- Helicobacter pylori-related gastroenterology studies
- BRCA gene mutations in cancer
- Synthesis and Biological Evaluation
- Gut microbiota and health
- Computational Drug Discovery Methods
- Telomeres, Telomerase, and Senescence
- Hand Gesture Recognition Systems
- Genetics, Aging, and Longevity in Model Organisms
Marmara University
2016-2023
The rising prevalence of many chronic diseases related to gut barrier dysfunction coincides with the increased global usage dietary emulsifiers in recent decades. We therefore investigated effect frequently used food on cytotoxicity, function, transcriptome alterations, and protein expression gastrointestinal epithelial cells.Human intestinal organoids originating from induced pluripotent stem cells, colon organoid organ-on-a-chip, liquid-liquid interface cells were cultured presence two...
Antigen presentation by major histocompatibility complex (MHC) proteins to T-cell receptors (TCRs) plays a crucial role in triggering the adaptive immune response. Most of our knowledge on TCR–peptide-loaded (pMHC) interaction stemmed from experiments yielding static structures, yet dynamic aspects this molecular are equally important understand underlying mechanisms and develop treatment strategies against diseases such as cancer autoimmune diseases. To end, computational biophysics studies...
Telomeres, and telomere length in particular, have broad significance for genome biology thus are prime research targets complex diseases such as cancers. In this context, BRCA1 BRCA2 gene mutations been implicated relationship to length, breast cancer susceptibility. Yet, the linkages among human genetic variation persons with high hereditary risk inadequately mapped. We report here original findings 113 unrelated women at cancer, who were characterized using next-generation sequencing....
Caspases are members of a highly regulated aspartate-cysteine protease family which have important roles in apoptosis. Pharmaceutical studies focused on these molecules since they involved diseases such as cancer and neurodegenerative disorders. A small molecule binds to the dimeric interface away from binding site induces conformational change that resembles pro-caspase form by shifting loop positions. The fluctuation mechanisms caused mutations or ligand can explain key mechanism for...