A5020005195- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Gut microbiota and health
- Contact Dermatitis and Allergies
- Barrier Structure and Function Studies
- COVID-19 Clinical Research Studies
- Respiratory and Cough-Related Research
- Skin Protection and Aging
- SARS-CoV-2 and COVID-19 Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- IL-33, ST2, and ILC Pathways
- Air Quality and Health Impacts
- Healthcare cost, quality, practices
- Olfactory and Sensory Function Studies
- Veterinary Practice and Education Studies
- Inhalation and Respiratory Drug Delivery
- Inflammatory Bowel Disease
- Microbial Metabolism and Applications
- COVID-19 Impact on Reproduction
- Exercise and Physiological Responses
- Circadian rhythm and melatonin
- Human-Animal Interaction Studies
- Eosinophilic Esophagitis
- Immunotoxicology and immune responses
University of Zurich
2021-2025
Nationwide Children's Hospital
2023
Adnan Menderes University
2020-2022
Memorial Ankara Hospital
2022
Koç University
2022
Fondazione IRCCS Istituto Nazionale dei Tumori
2022
CK-CARE
2022
AO Foundation
2022
Abstract The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting barrier. Global pollution toxic agent exposure have worsened over six decades because of uncontrolled growth, modernization, industrialization, affecting human health. Introducing new chemicals without any reasonable control their health effects through these years has led documented adverse effects, especially on...
The rising prevalence of many chronic diseases related to gut barrier dysfunction coincides with the increased global usage dietary emulsifiers in recent decades. We therefore investigated effect frequently used food on cytotoxicity, function, transcriptome alterations, and protein expression gastrointestinal epithelial cells.Human intestinal organoids originating from induced pluripotent stem cells, colon organoid organ-on-a-chip, liquid-liquid interface cells were cultured presence two...
Abstract Background Epithelial barrier impairment is associated with many skin and mucosal inflammatory disorders. Laundry detergents have been demonstrated to affect epithelial function in vitro using air–liquid interface cultures of human cells. Methods Back C57BL/6 mice was treated two household laundry at several dilutions. Barrier assessed by electric impedance spectroscopy (EIS) transepidermal water loss (TEWL) measurements after the 4 h treatments detergents. RNA sequencing (RNA‐seq)...
ABSTRACTPollution in the world and exposure of humans nature to toxic substances is continuously worsening at a rapid pace. In last 60 years, human domestic animal health has been challenged by continuous pollutants because uncontrolled growth, modernization, industrialization. More than 350,000 new chemicals have introduced our lives, mostly without any reasonable control their effects toxicity. A plethora studies show these harmful during this period with implications on skin mucosal...
Abstract The “epithelial barrier hypothesis” proposes that genetic predisposition to epithelial damage, exposure various barrier–damaging agents and chronic periepithelial inflammation are responsible for the development of allergic autoimmune diseases. Particularly, introduction more than 200,000 new chemicals our daily lives since 1960s has played a major role in pandemic increase these constitutes first line physical, chemical, immunological defence against external factors. A leaky...
Viral infections and type 2 immune responses perpetuate airway epithelial barrier dysfunction inflammation, leading to the development progression of asthma. The synthetic cannabinoid WIN55,212-2 displays anti-inflammatory properties by acting on different system cells. To investigate capacity restore bronchial function in asthma context viral or 2-driven inflammation. Air-liquid-interface (ALI) cultures human cells spheroids were generated assess damage induced rhinovirus A16 (RV-A16)...