A5063056062- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- IL-33, ST2, and ILC Pathways
- Contact Dermatitis and Allergies
- Exercise and Physiological Responses
- Psoriasis: Treatment and Pathogenesis
- Transgenic Plants and Applications
- Immune Cell Function and Interaction
- Gut microbiota and health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cutaneous lymphoproliferative disorders research
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Genetic Associations and Epidemiology
- Cancer Genomics and Diagnostics
- T-cell and B-cell Immunology
- Genetic Mapping and Diversity in Plants and Animals
- Evolution and Genetic Dynamics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Streptococcal Infections and Treatments
- Nail Diseases and Treatments
- Advancements in Transdermal Drug Delivery
- Cytokine Signaling Pathways and Interactions
Helmholtz Zentrum München
2008-2025
University Hospital Schleswig-Holstein
2016-2025
University of Lübeck
2016-2025
Kiel University
2011-2024
Center for Environmental Health
2024
Technical University of Munich
2006-2013
Ludwig-Maximilians-Universität München
2013
Hospital de Referencia La Equina
2010
University of St Andrews
2009
Imperial College London
2009
High levels of serum IgE are considered markers parasite and helminth exposure. In addition, they associated with allergic disorders, play a key role in anti-tumoral defence, crucial mediators autoimmune diseases. Total is strongly heritable trait. genome-wide association study (GWAS), we tested 353,569 SNPs for 1,530 individuals from the population-based KORA S3/F3 study. Replication was performed four independent samples (total n = 9,769 individuals). Functional variants gene encoding...
Abstract Omalizumab, a monoclonal antibody targeting I g E , is an established therapy for severe allergic asthma and has shown efficacy in chronic spontaneous urticaria. Small‐scale studies indicated some beneficial effect also atopic dermatitis ( AD ). To evaluate the of omalizumab to identify markers associated with treatment response, we conducted prospective 28‐week open‐label trial on 20 adults moderate‐to‐severe . Our results confirm previous observations positive response subgroup...
Abstract The transmembrane protein claudin-1 is a major component of epidermal tight junctions (TJs), which create dynamic paracellular barrier in the epidermis. Claudin-1 downregulation has been linked to atopic dermatitis (AD) pathogenesis but variable levels have also observed healthy skin. To elucidate impact different and diseased skin we determined AD patients controls correlated them TJ function. We strikingly broad range with stable overall function non-lesional However, significant...
Abstract Despite the increasing knowledge about factors shaping human microbiome, host genetic that modulate skin-microbiome interactions are still largely understudied. This contrasts with recent efforts to characterize genes influence gut microbiota. Here, we investigated effect of genetics on skin microbiota across three different microenvironments through meta-analyses genome-wide association studies (GWAS) two population-based German cohorts. We identified 23 significant loci harboring...