A5088825362- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Allergic Rhinitis and Sensitization
- Toxin Mechanisms and Immunotoxins
- Advancements in Transdermal Drug Delivery
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Cell Adhesion Molecules Research
- Multiculturalism, Politics, Migration, Gender
- Hair Growth and Disorders
- NF-κB Signaling Pathways
- Cutaneous lymphoproliferative disorders research
- Monoclonal and Polyclonal Antibodies Research
- Healthcare Systems and Public Health
- Nail Diseases and Treatments
- French Urban and Social Studies
- Transgenic Plants and Applications
- Autoimmune Bullous Skin Diseases
- RNA regulation and disease
- Sphingolipid Metabolism and Signaling
- RNA Interference and Gene Delivery
- Skin Protection and Aging
- Plant Reproductive Biology
- Lipid Membrane Structure and Behavior
- Plasma Applications and Diagnostics
Centre National de la Recherche Scientifique
2012-2025
Université de Toulouse
2015-2025
Université Toulouse III - Paul Sabatier
2015-2025
Inserm
2016-2025
Université de Lorraine
2024
Interdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes – Région Est
2024
John Wiley & Sons (United States)
2022-2023
Institut Toulousain des Maladies Infectieuses et Inflammatoires
2021-2022
Hôpital Purpan
1985-2019
Laboratoire de Chimie Physique - Matière et Rayonnement
2019
Antifilaggrin autoantibodies (AFA) are a population of IgG associated to rheumatoid arthritis (RA), which includes the so-called "antikeratin" Abs and antiperinuclear factor. AFA most specific serological markers RA. We previously showed that they recognize human epidermal filaggrin other profilaggrin-related proteins various epithelial tissues. Here, we report further characterization protein Ags epitopes targeted by AFA. All exhibit numerous neutral/ acidic isoelectric variants were...
Abstract Objective Autoantibodies to citrullinated proteins (ACPAs) are specific for rheumatoid arthritis (RA) and probably involved in its pathophysiology. Citrullyl residues, posttranslationally generated by peptidyl arginine deiminase (PAD), indispensable components of ACPA‐targeted epitopes. The aim this study was identify which PAD isotypes expressed the synovial tissue (ST) patients with RA citrullination fibrin, major target ACPAs. Methods Expression all isotypes, including recently...
The so-called antikeratin antibodies (AKA) and the antiperinuclear factor (APF) are most specific serological markers of RA. Using indirect immunofluorescence, AKA label stratum corneum various cornified epithelia APF keratohyalin granules human buccal mucosa epithelium. We recently demonstrated that recognize epidermal filaggrin. Here, we report identification major antigen as a diffuse protein band 200-400 kD. This is seen to be closely related (pro) filaggrin since it was recognized by...
In rheumatoid arthritis (RA), the high diagnostic value of serum antibodies to stratum corneum rat esophagus epithelium has been widely reported. These so-called "antikeratin antibodies," detected by indirect immunofluorescence, were found be autoantibodies since they also labeled human epidermis. Despite their name, actual target these was not known. this study, a 40-kD protein (designated as 40K), extracted from epidermis and specifically immunodetected 75% RA sera, purified identified...
Central centrifugal cicatricial alopecia (CCCA) is the most common form of scarring among women African ancestry. The disease occasionally observed to affect in families a manner that suggests an autosomal dominant trait and usually manifests clinically after intense hair grooming. We sought determine whether there exists genetic basis CCCA and, if so, what it is.
Corneodesmosin is a putative adhesion glycoprotein located in the extracellular part of desmosomes upper layers epidermis. Synthesized by granular keratinocytes as 52–56-kDa protein, corneodesmosin progressively proteolysed during corneocyte maturation. This processing prerequisite for desquamation. Two glycine- and serine-rich domains protein might take on conformation adhesive secondary structures similar to glycine loops.Corneodesmosin proteolysis was further characterized....
Peptidylarginine deiminases (PADs) catalyse a post-translational modification of proteins through the conversion arginine residues into citrullines. The existence four isoforms PAD (types I, II, III and IV) encoded by different genes, which are distinct in their substrate specificities tissue-specific expression, was reported rodents. In present study, starting from epidermis polyadenylated RNA, we cloned reverse transcriptase-PCR full-length cDNA encoding human type I. 2711bp length...
The morphological aspects of ageing and growth capacity were studied in 100 lines human liver cells. Under the culture conditions employed, cells appear to have a limited replicative life span. effects similar those described tissue other organs. Studies on potential showed that there was negative correlation between age donor at last passage, maximum number doublings, doublings phase II, end II. indices different for epithelial-like fibroblast-like
A single-nucleotide polymorphism within the gene encoding hornerin (HRNR) has recently been linked with atopic dermatitis (AD) susceptibility. HRNR shares features filaggrin, a key protein for keratino-cyte differentiation, but conflicting reports have published concerning its expression in epidermis, and role is still unknown. To analyze function anti-HRNR antibodies were produced used Western blot analysis immuno-histochemical, confocal, immunoelectron microscopy analyses of human skin...