A5010918025- Dermatology and Skin Diseases
- Computational Drug Discovery Methods
- Asthma and respiratory diseases
- Bioinformatics and Genomic Networks
- IL-33, ST2, and ILC Pathways
- Proteoglycans and glycosaminoglycans research
- Immune cells in cancer
- T-cell and B-cell Immunology
- Biomedical Text Mining and Ontologies
- Epigenetics and DNA Methylation
- Antimicrobial Resistance in Staphylococcus
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Periodontal Regeneration and Treatments
- Animal testing and alternatives
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacogenetics and Drug Metabolism
- Wound Healing and Treatments
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Hemostasis and retained surgical items
- Rabies epidemiology and control
- Sympathectomy and Hyperhidrosis Treatments
- Parvovirus B19 Infection Studies
- Mycobacterium research and diagnosis
Tampere University
2022-2025
Karolinska Institutet
2017-2023
University of Eastern Finland
2023
University of Lübeck
2017-2022
Kiel University
2018-2022
University Hospital Schleswig-Holstein
2017-2022
Abstract Despite the increasing knowledge about factors shaping human microbiome, host genetic that modulate skin-microbiome interactions are still largely understudied. This contrasts with recent efforts to characterize genes influence gut microbiota. Here, we investigated effect of genetics on skin microbiota across three different microenvironments through meta-analyses genome-wide association studies (GWAS) two population-based German cohorts. We identified 23 significant loci harboring...
BackgroundFew studies have analyzed the blood transcriptome in atopic dermatitis (AD).ObjectiveWe explored transcriptomic features of moderate to severe AD.MethodsBlood messenger RNA sequencing on 60 adults from TREATgermany registry including 49 patients before and after dupilumab treatment, as well an independent cohort 31 43 controls was performed. Patient clustering, differential expression, correlation coexpression network analysis, unsupervised learning were conducted.ResultsAD showed...
Leprosy, a chronic infectious disease caused by Mycobacterium leprae (M. leprae), was very common in Europe till the 16th century. Here, we perform an ancient DNA study on medieval skeletons from Denmark that show lesions specific for lepromatous leprosy (LL). First, test remains M. to confirm infection status of individuals and assess bacterial diversity. We assemble 10 complete genomes all differ each other. Second, evaluate whether human leukocyte antigen allele DRB1*15:01, strong LL...
Despite remarkable efforts of computational and predictive pharmacology to improve therapeutic strategies for complex diseases, only in a few cases have the predictions been eventually employed clinics. One reasons behind this drawback is that current approaches are based on integration molecular perturbation certain disease with drug sensitivity signatures, neglecting intrinsic properties drugs. Here we integrate mechanistic chemocentric repositioning by developing an innovative network...
The categorization of human diseases is mainly based on the affected organ system and phenotypic characteristics. This limiting view to pathological manifestations, while it neglects mechanistic relationships that are crucial develop therapeutic strategies. work aims advance understanding their relatedness beyond traditional views. Hence, similarity among 502 mapped using six different data dimensions encompassing molecular, clinical, pharmacological information retrieved from public...
Importance The epidemiological link between immune-mediated diseases (IMIDs) and cardiovascular disease has often been attributed to systemic inflammation. However, the direction of causality biological mechanisms linking with IMIDs are incompletely understood. Given robust association growing body supportive mechanistic evidence, psoriasis is an exemplary IMID model for exploring this relationship. Objective To assess bidirectional relationships genetic predictors 2 major forms disease,...
Pulmonary fibrosis (PF) is a life-threatening condition characterised by excessive extracellular matrix deposition and tissue scarring. While much of PF research has focused on alveolar epithelial cells fibroblasts, endothelial have emerged as active contributors to the disease initiation, especially in context systemic exposure pro-fibrotic substances. Here, we investigate early transcriptomic secretory responses human umbilical vein (HUVEC) subtoxic doses bleomycin, known agent, TGF-beta,...
The cell-surface heparan sulfate proteoglycan syndecan-1 is important for tumor cell proliferation, migration, and cycle regulation in a broad spectrum of malignancies. Syndecan-1, however, also translocates to the nucleus, where it might regulate various molecular functions. We used fibrosarcoma model dissect functions related nucleus separate them from cell-surface. Nuclear translocation hampered proliferation cells compared mutant lacking nuclear localization signal. growth inhibitory...
Assessing chemical safety is essential to evaluate the potential risks of exposure human health and environment. Traditional methods relying on animal testing are being replaced by 3R (reduction, refinement, replacement) principle-based alternatives, mainly depending in vitro test Adverse Outcome Pathway framework. However, these approaches often focus properties compound, missing broader chemical-biological interaction perspective. Currently, lack comprehensive molecular characterization...
Platelet-released growth factor (PRGF) is a thrombocyte concentrate lysate which, like its clinically equivalent variations (e.g., Vivostat PRF® (platelet-rich fibrin)), known to support the healing of chronic and hard-to-heal wounds. However, studies on effect PRGF keratinocytes remain scarce. This study aims identify genes in that are significantly influenced by PRGF. Therefore, we performed whole transcriptome gene ontology (GO) enrichment analysis PRGF-stimulated human primary...
Abstract Background Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease whose pathophysiology involves the interplay between genetic and environmental factors, ultimately leading to dysfunction of epidermis. While several treatments are effective in symptom management, many existing therapies offer only temporary relief often come with side effects. For this reason, formulation an therapeutic plan challenging there need for more targeted that address root causes...
Macrophage plasticity allows the adoption of distinct functional states in response to environmental cues. While unique transcriptomic profiles define these states, focusing solely on transcription neglects potential long-term effects. The investigation epigenetic changes can be used understand how temporary stimuli result lasting Epigenetic alterations play an important role pathophysiology macrophages, including their trained innate immunity, enabling faster and more efficient inflammatory...
<i>Staphylococcus aureus</i> is an important pathogen causing various infections, including – as most frequently isolated bacterium cutaneous infections. Keratinocytes the first barrier cells of skin respond to <i>S. by release defense molecules such cytokines and antimicrobial peptides. Although several pattern recognition receptors expressed in keratinocytes Toll-like NOD-like have been reported detect presence aureus</i>, mechanisms underlying interplay between are...
Abstract The categorization of human diseases is mainly based on the affected organ system and phenotypic characteristics. This limiting view to pathological manifestations, while it neglects mechanistic relationships that are crucial develop therapeutic strategies. work aims advance understanding their relatedness beyond traditional views. Hence, similarity among 502 mapped using six different data dimensions encompassing molecular, clinical, pharmacological information retrieved from...
Platelet concentrate products are increasingly used in many medical disciplines due to their regenerative properties. As they contain a variety of chemokines, cytokines, and growth factors, support the healing chronic or complicated wounds. To date, underlying cellular mechanisms have been insufficiently investigated. Therefore, we analyzed influence Platelet-Released Growth Factors (PRGF) on human dermal fibroblasts. Whole transcriptome sequencing gene ontology (GO) enrichment analysis...
In recent years, a growing interest in the characterization of molecular basis psoriasis has been observed. However, despite availability large amount data, many pathogenic mechanisms are still poorly understood. this study, we performed an integrated analysis 23 public transcriptomic datasets encompassing both lesional and uninvolved skin samples from patients. We defined comprehensive gene co-expression network models psoriatic lesions skin. Moreover, curated exploited wide range...
Abstract Cluster of differentiation 109 (CD109) is a glycosylphosphatidylinositol (GPI) anchored cell surface protein, expressed on epithelial and endothelial cells, CD4+ CD8+ T-cells, premature lymphocytes. CD109 interacts with different receptors thereby modulates intracellular signaling pathways, which ultimately changes cellular functions. One well-studied example the interaction TGFβ/TGFβ-receptor complex at surface. silences SMAD2/3 targets to endosomal/lysosomal compartment. In recent...
Abstract Macrophage plasticity allows the adoption of distinct functional states in response to environmental cues. While unique transcriptomic profiles define these states, focusing solely on transcription neglects potential long-term effects. The investigation epigenetic changes can be used understand how temporary stimuli result lasting Moreover, alterations play an important role pathophysiology macrophages, including phenomena related trained innate immunity, which allow faster and more...