A5036244539- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Fungal Infections and Studies
- Autoimmune Bullous Skin Diseases
- Cancer and Skin Lesions
- T-cell and Retrovirus Studies
- Genetic and rare skin diseases.
- CAR-T cell therapy research
- Autoimmune and Inflammatory Disorders
- Tumors and Oncological Cases
- CNS Lymphoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Syphilis Diagnosis and Treatment
- Nail Diseases and Treatments
- Dermatological and Skeletal Disorders
- Immunodeficiency and Autoimmune Disorders
- Dermatology and Skin Diseases
- Hidradenitis Suppurativa and Treatments
- Asthma and respiratory diseases
- Ear and Head Tumors
- Hedgehog Signaling Pathway Studies
- Leprosy Research and Treatment
- Histone Deacetylase Inhibitors Research
- Inflammatory Myopathies and Dermatomyositis
- Exercise and Physiological Responses
Peking University First Hospital
2016-2025
Peking University
2016-2025
National Medical Products Administration
2022-2025
National Clinical Research Center for Digestive Diseases
2020-2025
University of Michigan
2011-2021
University of Chicago
2007
Abstract Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin distinguished by the presence clonal malignant cells. The heterogeneity cells and complex tumor microenvironment remain poorly characterized. With single-cell RNA analysis bulk whole-exome sequencing on 19 skin lesions from 15 CTCL patients, we decipher intra-tumor inter-lesion diversity patients propose multi-step evolution model. We further establish subtyping scheme based molecular features their...
The incidence of cutaneous paradoxical reactions associated with IL-17 inhibitors has gained attention in recent literature. Our report aims to investigate the characteristics one rare reaction, presenting as Behcet's disease.
Abstract Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma, undergo large-cell transformation (LCT) in late stage, manifesting aggressive behavior, resistance to treatments, and poor prognosis, but mechanisms involved remain unclear. To identify molecular driver LCT, we collected tumor samples from 133 MF patients performed whole-transcriptome sequencing on 49 advanced-stage patients, followed by integrated copy number inference genomic hybridization. Tumors with LCT...
Importance There are limited prognostic statistics and data available on survival outcomes for patients with mycosis fungoides (MF) in Asia. Objective To determine the factors of MF among a cohort China. Design, Setting, Participants This was retrospective study who received treatment at tertiary referral center skin lymphoma (Peking University First Hospital, Beijing, China) from August 1, 2009, to 31, 2021. Data were analyzed September 2021, December 2022. Main Outcomes Measures Overall...
Cutaneous T cell lymphoma is a generally indolent disease derived from skin-homing mature cells. However, in advanced stages, cutaneous may manifest aggressive clinical behaviour and lead to poor prognosis. The mechanism of progression remains unknown. This study, based on large cohort, found that IKZF2, an essential transcription factor during development differentiation, showed stage- dependent overexpression the malignant cells mycosis fungoides lesions. IKZF2 specifically over- expressed...
Abstract Immunoglobulin (Ig)G4 expression was recently observed in a proportion of primary cutaneous marginal zone B‐cell lymphoma (PCMZL) with plasmacytic differentiation. IgG4‐related disease is characterised by polyclonal lymphoplasmacytic infiltration IgG4 expression, storiform fibrosis and obliterative phlebitis histopathology. Here we report three cases common variants PCMZL predominant varied suggesting there an underlying clonal progression between these two entities.
Chronic lymphedema predisposes to develop malignant cutaneous tumors, including angiosarcoma, Kaposi's sarcoma and B‐cell lymphoma. T‐cell malignancy has rarely been associated with chronic lymph stasis. Here, we report a case of primary anaplastic large cell lymphoma ( pcALCL ) lymphatic spread lymphedema. The patient is 56‐year‐old man who received orchiectomy right inguinal lymphadenectomy for seminoma 10 years ago, which led prominent the leg. He developed extensive skin nodules on...
Differential diagnosis of erythroderma is challenging in dermatology, especially differentiating erythrodermic cutaneous T-cell lymphoma from inflammatory dermatoses. This study retrospectively reviewed the peripheral blood flow cytometric results 73 patients diagnosed with at Peking University First Hospital 2014 to 2019. The cytometry antibody panel included white cell markers, B-cell activation and T helper differentiation markers. Features surface antigens were compared between 34 39...
Discriminating between cutaneous anaplastic large cell lymphoma (cALCL) and CD30-positive transformed mycosis fungoides (CD30+ TMF) is challenging, particularly when they arise in the context of pre-existing fungoides. The development molecular diagnostic tools was hampered by rarity both diseases limited understanding their pathogenesis.In this study, we established a cohort comprising 25 cALCL cases CD30+ TMF cases, with transcriptomic data obtained from 31 samples. We compared...
We aim to investigate the changes of plasma proteome among mild, severe adolescent idiopathic scoliosis (AIS) patients and healthy controls.In this retrospective study, there were 84 individuals including 56 confirmed AIS (27 follow-up 29 surgical patients) another 28 teenagers. Plasma samples obtained Quadrupole-Orbitrap Mass Spectrometer was performed identify proteins in control group. T-test ANOVA screen for differential proteins. GO KEGG pathway, Pearson's correlation analysis PLS model...