A5065636025- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Pancreatic function and diabetes
- T-cell and B-cell Immunology
- Endoplasmic Reticulum Stress and Disease
- Asthma and respiratory diseases
- Telomeres, Telomerase, and Senescence
- Microscopic Colitis
- Stress Responses and Cortisol
- Advanced Breast Cancer Therapies
- Digital literacy in education
- Cancer Treatment and Pharmacology
- Pluripotent Stem Cells Research
- Genetic and rare skin diseases.
- Digestive system and related health
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Thyroid Disorders and Treatments
- S100 Proteins and Annexins
- Online and Blended Learning
- Eosinophilic Esophagitis
- Hypothalamic control of reproductive hormones
- Genetics, Aging, and Longevity in Model Organisms
Washington University in St. Louis
2019-2025
Union Hospital
2023-2024
Huazhong University of Science and Technology
2021-2024
Union Hospital
2021
University of Pennsylvania
2015-2016
University of British Columbia
2008
Cytokines employ downstream Janus kinases (JAKs) to promote chronic inflammatory diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with JAK1 gain-of-function (GoF) variants develop atopic dermatitis (AD) asthma. To explore tissue-specific functions, we inserted a human GoF variant (JAK1GoF) into mice observed the development of spontaneous AD-like skin disease but unexpected resistance lung inflammation when JAK1GoF expression was restricted stroma. We...
OBJECTIVE—Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of diabetes, but roles specific ER Ca2+ release channels stress–associated apoptosis pathway remain unknown. Here, we examined effects stimulating or inhibiting ER-resident inositol trisphosphate receptors (IP3Rs) and ryanodine (RyRs) on induction β-cell apoptosis. RESEARCH DESIGN AND METHODS—Kinetics death were tracked by imaging propidium iodide incorporation caspase-3 activity real time. assessed Western...
There are strong links between obesity, elevated free fatty acids, and type 2 diabetes. Specifically, the saturated acid palmitate has pleiotropic effects on beta-cell function survival. In present study, we sought to determine mechanism by which affects intracellular Ca2+, in particular role of endoplasmic reticulum (ER). human beta-cells MIN6 cells, rapidly increased cytosolic Ca2+ through a combination store release extracellular influx. Palmitate caused reversible lowering ER measured...
It has been reported that melatonin can relieve the symptoms of chronic obstructive pulmonary disease (COPD) by improving sleep quality, is to say, pineal secreted hormone a protective effect in pathogenesis COPD, but its underlying mechanism remains unclear. In this study, we recruited 73 people into control (n = 22), stable COPD 20), and acute exacerbation 31) groups detect serum levels. Then, through mouse model, employed systematic study based on metabolomic transcriptomic analyses...
Circular RNAs (circRNAs) have emerged as critical regulators of cell biology. However, their function in breast cancer remains elusive. Herein, through circRNA profiling 38 tumors and 10 benign tissues, we identified 509 differentially expressed circRNAs. Integration with transcriptome-wide functional screening approximately 10,000 circRNAs pinpointed circNSD1 a top ranked tumor suppressor cancer. CircNSD1 is downregulated suppression the circular form, but not linear promotes proliferation...
Antigen specificity is the central trait distinguishing adaptive from innate immune function. Assembly of antigen-specific T cell and B receptors occurs through V(D)J recombination mediated by Recombinase Activating Gene endonucleases RAG1 RAG2 (collectively called RAG). In absence RAG, mature cells do not develop thus RAG critically associated with addition to helper 2 (Th2) cells, group lymphoid (ILC2s) contribute type responses producing cytokines like Interleukin-5 (IL-5) IL-13. Although...
Glycosylation of cell surface proteins can regulate multiple cellular functions. We hypothesized that glycosylation and expression glycoproteins after epithelial injury is important in mediating repair. report the use an vitro culture model human airway cells (1HAEo(-)) to identify mediators characterized carbohydrate moieties associated with repair by their interaction lectin from Cicer arietinum, chickpea agglutinin (CPA). Using CPA, we identified changes during wound Following mechanical...
Abstract Tamoxifen (TAM) is the frontline therapy for estrogen receptor-positive (ER+) breast cancer in premenopausal women that interrupts ER signaling. As tumors with elevated heterogeneity, amounts of ER-negative (ER−) cells are present ER+ cannot be directly killed by TAM. Despite complete remissions have been achieved clinical practice, mechanism underlying elimination ER− during TAM treatment remains an open issue. Herein, we deciphered from perspective bystander effect. Markable...
Hashimoto's thyroiditis (HT) is an autoimmune disruption manifested by immune cell infiltration in thyroid tissue and the production of antibodies against thyroid-specific antigens, such as peroxidase antibody (TPOAb) thyroglobulin (TGAb). TPOAb TGAb are commonly used clinical tests; however, handy indicators diagnosis progression HT still scarce. Extracellular proteins glycosylated likely to enter body fluids become readily available detectable biomarkers. Our research aimed discover...
ABSTRACT Antigen specificity is the central trait distinguishing adaptive from innate immune function. Assembly of antigen-specific T cell and B receptors occurs through V(D)J recombination mediated by Recombinase Activating Gene endonucleases RAG1 RAG2 (collectively called RAG). In absence RAG, mature cells do not develop thus RAG critically associated with addition to helper 2 (Th2) cells, group lymphoid (ILC2s) contribute type responses producing cytokines like Interleukin-5 (IL-5) IL-13....
Antigen specificity is the central trait distinguishing adaptive from innate immune function. Assembly of antigen-specific T cell and B receptors occurs through V(D)J recombination mediated by Recombinase Activating Gene endonucleases RAG1 RAG2 (collectively called RAG). In absence RAG, mature cells do not develop thus RAG critically associated with addition to helper 2 (Th2) cells, group lymphoid (ILC2s) contribute type responses producing cytokines like Interleukin-5 (IL-5) IL-13. Although...
Antigen specificity is the central trait distinguishing adaptive from innate immune function. Assembly of antigen-specific T cell and B receptors occurs through V(D)J recombination mediated by Recombinase Activating Gene endonucleases RAG1 RAG2 (collectively called RAG). In absence RAG, mature cells do not develop thus RAG critically associated with addition to helper 2 (Th2) cells, group lymphoid (ILC2s) contribute type responses producing cytokines like Interleukin-5 (IL-5) IL-13. Although...
Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and noxious stimuli from the skin. However, in organ failure, cancer, chronic inflammatory disorders like atopic dermatitis (AD), itch becomes chronic, intractable, debilitating. In addition to itch, patients often experience intense acute exacerbations. Recent seminal discoveries have unearthed neuroimmune circuitry leading development novel treatments. mechanisms underlying exacerbations remain...
Cytokines employ downstream Janus kinases (JAKs) to promote many chronic inflammatory disorders. JAK1-dependent type 2 cytokines drive allergic inflammation and patients with JAK1 gain-of-function (GOF) variants develop atopic dermatitis (AD) asthma. To explore the tissue-specific role of JAK1, we inserted a human GOF variant into mice observed spontaneous development AD-like skin but unexpected resistance lung when expression was restricted stroma. Strikingly, identified previously...