A5101694845- Lung Cancer Diagnosis and Treatment
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Disorders and Functions
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Glycosylation and Glycoproteins Research
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Metabolomics and Mass Spectrometry Studies
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- vaccines and immunoinformatics approaches
- Psoriasis: Treatment and Pathogenesis
- Chronic Myeloid Leukemia Treatments
- Cell death mechanisms and regulation
- Circular RNAs in diseases
- Mycobacterium research and diagnosis
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
Shantou University
2025
Beijing University of Chinese Medicine
2020-2024
Third Affiliated Hospital of Zhengzhou University
2024
Boston University
2024
West China Hospital of Sichuan University
2023-2024
Research Institute of Petroleum Exploration and Development
2024
Sichuan University
2023-2024
Beijing Proteome Research Center
2024
Anhui Medical University
2024
Chinese PLA General Hospital
2021-2023
Metabolic reprogramming, immune evasion and tumor-promoting inflammation are three hallmarks of cancer that provide new perspectives for understanding the biology cancer. We aimed to figure out relationship tumor glycolysis immune/inflammation function in context breast cancer, which is significant deeper biology, treatment prognosis cancer.Using mRNA transcriptome data, tumor-infiltrating lymphocytes (TILs) maps based on digitized H&E-stained images clinical information from The Cancer...
Background: Tumor microenvironment is essential for breast cancer progression and metastasis. Our study sets out to examine the stromal immune infiltration in progression, prognosis treatment. Materials Methods: This work provides an approach quantifying scores by using ESTIMATE algorithm based on gene expression matrix of patients TCGA database. We found differentially expressed genes (DEGs) through limma R package. Functional enrichments were accessed Gene Ontology (GO) analysis Kyoto...
Nonalcoholic fatty liver disease (NAFLD) has become an increasingly common in Western countries and the major cause of cirrhosis or hepatocellular carcinoma (HCC) addition to viral hepatitis recent decades. Furthermore, studies have shown that NAFLD is inextricably linked development extrahepatic diseases. However, there currently no effective treatment cure NAFLD. In addition, 2020, was renamed metabolic dysfunction (MAFLD) show its pathogenesis closely related disorders. Recent reported...
The liver is the largest solid organ in body and primarily composed of hepatocytes (HCs), endothelial cells (ECs), Kupffer (KCs), hepatic stellate (HSCs), which spatially interact cooperate with each other to maintain homeostasis. However, complexity molecular mechanisms underlying crosstalk between these different cell types remain be revealed. Here, we generated mice conditional deletion Gdf2 (also known as Bmp9 ) Bmp10 demonstrated that HSCs were major source GDF2 BMP10 liver. Using...
The interaction between CD4 and major histocompatibility complex class II proteins provides a critical co-receptor function for the activation of CD4(+) T cells implicated in pathogenesis number autoimmune diseases transplantation responses. A small synthetic cyclic heptapeptide was designed shown by high resolution NMR spectroscopy to closely mimic domain 1 CC' surface loop. This peptide effectively blocked stable CD4-major interaction, possessed significant immunosuppressive activity vitro...
The interaction between CD4 and major histocompatibility complex (MHC) class II proteins is critical for the activation of + T cells, which are involved in transplantation reactions a number autoimmune diseases. In this study we have identified surface pocket as functional epitope implicated CD4–MHC T-cell activation. A computer-based strategy has been used to screen ≈150,000 non-peptidic organic compounds molecular data base identify group ligands proposed pocket. These small shown...
Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disease characterized by chronic visceral pain with complex etiology and challenging treatment. Although accumulating evidence supports the involvement of central nervous system sensitization in development pain, precise molecular mechanisms remain incompletely understood. In this study, we highlight critical regulatory role lysine-specific demethylase 6B (KDM6B) anterior cingulate cortex (ACC) pain. To simulate...
Circular RNAs (circRNAs) have emerged as critical regulators of cell biology. However, their function in breast cancer remains elusive. Herein, through circRNA profiling 38 tumors and 10 benign tissues, we identified 509 differentially expressed circRNAs. Integration with transcriptome-wide functional screening approximately 10,000 circRNAs pinpointed circNSD1 a top ranked tumor suppressor cancer. CircNSD1 is downregulated suppression the circular form, but not linear promotes proliferation...
Circular RNAs (circRNAs) constitute a novel class of noncoding showcasing distinct tissue- and cell-specific expression patterns. Despite the extensive profiling circRNAs, their individual functions remain poorly understood. To fill this gap, we designed genome-wide library 65,300 shRNAs, targeting 9,688 clinically relevant circRNAs 3,981 linear parental genes, conducted functional screening in seven types human cancer. We identified total 1,342 essential (13.8% screened) that impact cell...
ABSTRACT Flow velocity control is of great interest for passive microfluidic devices that are used in point‐of‐care diagnostics. Various methods have been developed the flow paper‐based analytical (µPADs), whereas fewer attempts made thread‐based (µTADs). In this research, we attempt to cotton µTADs with electroosmotic pumping. Utilizing pumps, can be decreased or increased by 13% and 106%, respectively. Moreover, dynamic achieved adjusting real‐time magnitude direction voltage. Furthermore,...
This study aimed to develop a prognostic model for clear cell renal carcinoma (ccRCC) based on transcriptome analysis. We screened Gene Expression Omnibus (GEO) database and the Cancer Genome Atlas (TCGA) gene expression data clinical characteristics of ccRCC. After differentially analysis, we identified 533 key genes development Next, weighted co-expression network analysis (WGCNA) was executed investigate association between expressed characteristics. Then, protein-protein interaction...
Abstract Objective The study aimed to explore the mechanism of artemisinin in treating primary Sjögren’s syndrome (pSS) based on network pharmacology and experimental validation. Methods Relevant targets pSS-related were integrated by public databases online. An artemisinin-pSS was constructed Cytoscape. genes regulating pSS imported into STRING database construct a protein-protein interaction (PPI) order predict key targets. enrichment analyses performed crucial pathway against pSS. active...
Over the past decade, Cancer detection using deep learning models has been a hot topic, especially in medical image classification. It is worth remarking that CNN are more advanced at addressing diagnose diseases such as lung cancers because of higher performance and ability CNN. However, few methods focus on pathological classification provide detailed model configuration. In this paper, hybrid including inception_v3 network, hog daisy feature extraction modules constructed to classify...
Abstract Background Osimertinib is the standard first‐line treatment for non‐small cell lung cancer (NSCLC) patients with epidermal growth factor receptor ( EGFR ) mutation. Resistance to osimertinib remains a clinical challenge. However, optimal therapy these still controversial. In this study, we aimed assess efficacy and safety of immunotherapy plus chemotherapy (IO+C) compared (C) in NSCLC after progression on osimertinib. Methods Advanced were retrospectively reviewed. Progression‐free...
Objective The study was designed to explore the evolution of non-small cell lung cancer (NSCLC) management in last 20 years. Methods top 100 most-cited papers on NSCLC treatment were retrieved from Web Science Core Collection database. R and VOSviewer used extract bibliographic information, including year publication, countries/regions, institutions, authors, journals, keywords, impact factor, total citations. topic type checked independently by authors. Bibliometric analysis conducted...