A5062482652- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Disorders and Functions
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- Psoriasis: Treatment and Pathogenesis
- Ionic liquids properties and applications
- Protein Structure and Dynamics
- Neonatal Respiratory Health Research
- Enzyme Structure and Function
- Invertebrate Immune Response Mechanisms
- Molecular Communication and Nanonetworks
- Advanced biosensing and bioanalysis techniques
- Systemic Sclerosis and Related Diseases
- Platelet Disorders and Treatments
- Congenital Diaphragmatic Hernia Studies
- Traditional and Medicinal Uses of Annonaceae
- Salivary Gland Tumors Diagnosis and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
West China Second University Hospital of Sichuan University
2019-2025
Sichuan University
2019-2025
Université de Strasbourg
2016-2024
Inserm
2022-2024
Beijing University of Chinese Medicine
2022-2024
China-Japan Friendship Hospital
2023
Shanxi University of Traditional Chinese Medicine
2023
University of Freiburg
2009-2022
Anhui Provincial Hospital
2019-2020
Max Planck Institute of Immunobiology and Epigenetics
2006-2019
Abstract IL-2 −/− mice develop autoimmunity despite having relatively normal numbers of regulatory T cells (Tregs). In contrast, we demonstrate that IL-2−/− × IL-15−/− and IL-2Rβ−/− have a significant decrease in Treg numbers. Ectopic expression foxp3 subset CD4+ rescued development prevented mice, suggesting IL-2Rβ-dependent signals regulate Tregs. Subsequent analysis signal transduction pathways established the transcription factor STAT5 is necessary sufficient for development....
Abstract Common γ chain (γc)-receptor dependent cytokines are required for regulatory T cell (Treg) development as γc−/− mice lack Tregs. However, it is unclear which γc-dependent involved in this process. Furthermore, thymic stromal lymphopoietin (TSLP) has also been suggested to play a role Treg development. In study, we demonstrate that developing CD4+Foxp3+ Tregs the thymus express IL-2Rβ, IL-4Rα, IL-7Rα, IL-15Rα, and IL-21Rα chains, but not IL9Rα or TSLPRα chains. Moreover, only IL-2,...
Binding of antigen to the B cell receptor (BCR) initiates a multitude events resulting in activation. How BCR becomes signaling-competent upon binding is still matter controversy. Using high-resolution proximity ligation assay (PLA) monitor conformation and its interactions with co-receptors at 10–20 nm resolution, we provide direct evidence for opening dimers during We also show that Syk opens by an inside-out signaling mechanism amplifies signaling. Furthermore, found on resting cells,...
Regulatory T cell (Treg) development proceeds via a two-step process in which naive CD4(+) thymocytes are first converted into CD4(+)CD25(+)CD122(+)GITR(+)Foxp3(-) Treg progenitors, followed by second step IL-2 converts these progenitors CD4(+)Foxp3(+) Tregs. The costimulatory molecule CD28 is required for efficient development. However, the stage at affects remains undefined. In this article, we demonstrate that Cd28(-/-) mice lack progenitors. Furthermore, P(187)YAP motif cytoplasmic tail...
Natural regulatory T cells (nTregs) that develop in the thymus are essential to limit immune responses and prevent autoimmunity. However, steps necessary for their thymic development incompletely understood. The CARMA1/Bcl10/Malt1 (CBM) complex, comprised of adaptors link TCR transcription factor NF-kappaB, is required (Tregs) but not conventional cells. Current models propose TCR-NF-kappaB needed a Treg-extrinsic manner IL-2 production by or already precommitted Treg precursors driving...
Article18 April 2018Open Access Transparent process Continuous signaling of CD79b and CD19 is required for the fitness Burkitt lymphoma B cells Xiaocui He orcid.org/0000-0002-0106-057X BIOSS Centre For Biological Signaling Studies, Department Molecular Immunology, Biology III, Faculty Biology, University Freiburg, Germany Max Planck Institute Immunobiology Epigenetics, Search more papers by this author Kathrin Kläsener orcid.org/0000-0002-5969-2553 Joseena M Iype Martin Becker...
Agammaglobulinemia is a rare primary immunodeficiency characterized by an early block of B cell development in the bone marrow, resulting absence peripheral cells and low/absent immunoglobulin serum levels. So far, mutations Btk, μ heavy chain, surrogate light Igα, linker have been found 85–90% patients with agammaglobulinemia. We report on first patient agammaglobulinemia caused homozygous nonsense mutation Igβ, which transmembrane protein that associates Igα as part preBCR complex....
Article15 September 2016Open Access Source DataTransparent process Molecular requirements of the B-cell antigen receptor for sensing monovalent antigens Christoph Volkmann BIOSS Centre Biological Signalling Studies, Department Immunology, Biology III, Faculty Biology, University Freiburg, Germany Max Planck Institute Immunobiology and Epigenetics, Search more papers by this author Naema Brings Martin Becker Elias Hobeika Hospital Ulm, Jianying Yang Corresponding Author [email protected]...
Psoriasis is one of the most common skin inflammatory diseases worldwide. The vitamin D3 analog calcipotriol has been used alone or in combination with corticosteroids treating plaque psoriasis, but how it suppresses psoriatic inflammation not fully understood. Using an experimental mouse psoriasis model, we show that topical inhibited pivotal IL-23/IL-17 axis and neutrophil infiltration skin, interestingly, such effects were mediated through D receptor (VDR) keratinocytes (KCs). We further...
We describe the results of two vaccinations a self-experimenting healthy volunteer with SARS-CoV-2-derived peptides performed in March and April 2020, respectively. The first set contained eight predicted to bind individual’s HLA molecules. second consisted ten promiscuously several HLA-DR allotypes. vaccine formulation new TLR 1/2 agonist XS15 was administered as an emulsion Montanide single subcutaneous injection. Peripheral blood mononuclear cells isolated from drawn before after were...
Seawater electrolysis has emerged as a promising approach for the generation of hydrogen energy, but production deleterious chlorine derivatives (e.g., chloride and hypochlorite) presents significant challenge due to severe corrosion at anode. Transition metal-coordinated polymers have garnered attention electrocatalysts alkaline seawater oxidation (ASO), attributed their remarkable resistance, high conductivity, facile synthesis. In this study, we employ an anodic...