A5017251582- Liver Diseases and Immunity
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Liver physiology and pathology
- Dermatology and Skin Diseases
- Gallbladder and Bile Duct Disorders
- Macrophage Migration Inhibitory Factor
- CAR-T cell therapy research
- Tryptophan and brain disorders
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Cytomegalovirus and herpesvirus research
- Psoriasis: Treatment and Pathogenesis
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Phagocytosis and Immune Regulation
- Infant Nutrition and Health
- Vitamin D Research Studies
- Gut microbiota and health
University Medical Center Hamburg-Eppendorf
2020-2025
Universität Hamburg
2020-2025
University of Freiburg
2014-2019
Psoriasis is one of the most common skin inflammatory diseases worldwide. The vitamin D3 analog calcipotriol has been used alone or in combination with corticosteroids treating plaque psoriasis, but how it suppresses psoriatic inflammation not fully understood. Using an experimental mouse psoriasis model, we show that topical inhibited pivotal IL-23/IL-17 axis and neutrophil infiltration skin, interestingly, such effects were mediated through D receptor (VDR) keratinocytes (KCs). We further...
Treating autoimmune diseases without nonspecific immunosuppression remains challenging. To prevent or treat these conditions through targeted immunotherapy, we developed a clinical-stage nanoparticle platform that leverages the tolerogenic capacity of liver sinusoidal endothelial cells (LSECs) to restore antigen-specific immune tolerance. In vivo efficacy was evaluated in various CD4+ T cell-mediated disease models, including preventive and therapeutic models myelin oligodendrocyte...
Autoimmune diseases are caused by adaptive immune responses to self-antigens. The development of antigen-specific therapies that suppress disease-related, but not unrelated in general, is an important goal biomedical research. We have previously shown delivery myelin peptides liver sinusoidal endothelial cells (LSECs) using LSEC-targeting nanoparticles provides effective protection from CD4 T-cell-driven autoimmune encephalomyelitis. Here, we investigated whether this methodology might also...
Significance The specific activation of B lymphocytes via the binding antigen to their cell receptor (BCR) is central importance for establishment humoral immunity and a successful vaccination. A better understanding sensing process cells requires insight into structure BCR comprising mIg molecule Igα/Igβ heterodimer in 1:1 complex. How symmetric such as asymmetrically associated with only one has been puzzle. We suggest that inside lipid bilayer forms Igα-mHC:mHC-Igβ Our results give mechanism.
Background & AimsThe liver has a distinct capacity to induce immune tolerance hepatic antigens. Although can be advantageous for preventing autoimmune and inflammatory diseases, it also detrimental by surveillance of infected or malignant cells. Here, we investigated the mechanisms that establish tolerance.MethodsTolerance was in C-reactive protein (CRP)–myelin basic (MBP) mice expressing neuroantigen MBP hepatocytes, providing profound resistance MBP-induced neuroinflammation. Tolerance...
Abstract Broad-spectrum antibiotics are frequently prescribed for children. The gut microbiota have functional roles in the development and differentiation of host immune system. Early-life antibiotic use may dynamic effects on microbiota, promoting long-term immunologic dysregulation subsequent allergic autoimmune pathology. Using a model early-life use, we hypothesize that pulsed treatment (PAT) -induced perturbation intestinal leads to alterations tissue-specific systemic T-cell...
We have previously shown that delivery of MHC II-restricted autoantigen peptides to liver sinusoidal endothelial cells (LSECs) using LSEC-targeting nanoparticles (NPs) provides effective protection from CD4 T cell-driven autoimmunity (Carambia et al. J Hepatol 2015). As LSECs are capable cross-present exogenous CD8 cells, we here investigated whether targeted I-restricted peptide might serve antigen-specific treatment autoimmunity. a model, used OT-I cholangitis in K14-OVAp mice expressing...
Background Liver sinusoidal endothelial cells (LSECs) contribute to the liver's ability induce immune tolerance. We have previously shown that LSECs can be harnessed for therapy of autoimmune disease by targeted delivery autoantigen-peptides with nanoparticles (NPs). Yet, in liver fibrosis, undergo capillarization and acquire enhanced immunogenicity. Here we explore whether fibrotic maintain their tolerance NP-delivered peptides.