A5021321096- melanin and skin pigmentation
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Biochemical Analysis and Sensing Techniques
- Mast cells and histamine
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Immunodeficiency and Autoimmune Disorders
- Urticaria and Related Conditions
- Cytokine Signaling Pathways and Interactions
- Autoimmune Bullous Skin Diseases
- Herpesvirus Infections and Treatments
- Skin Protection and Aging
- Acne and Rosacea Treatments and Effects
- Heat shock proteins research
- interferon and immune responses
- RNA regulation and disease
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Olfactory and Sensory Function Studies
- Drug-Induced Adverse Reactions
- Hair Growth and Disorders
Université de Bordeaux
2016-2025
Centre National de la Recherche Scientifique
2022-2025
Hôpital Saint-André
2017-2025
Centre Hospitalier Universitaire de Bordeaux
2018-2025
George Washington University
2013-2023
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2013-2022
Inserm
2013-2022
Immunology from Concept and Experiments to Translation
2022
Bordeaux Population Health
2014-2021
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2020
IL-22 belongs to a family of cytokines structurally related IL-10, including IL-19, IL-20, IL-24, and IL-26. In contrast has proinflammatory activities. signals through class II cytokine receptor composed an IL-22-binding chain, IL-22RA1, the IL-10RB subunit, which is shared with IL-10R. present study, we show that short-term cultured human epidermal keratinocytes express functional IL-22R but no Accordingly, not IL-10 induces STAT3 activation in keratinocytes. Using cDNA array screening...
The C-type lectin-like receptor CD161, which has recently been described to promote T cell expansion, is expressed on a discrete subset of human CD4 cells. function such cells, however, remained elusive. We now demonstrate that CD161+ cells comprise circulating and gut-resident helper 17 (Th17) population. During Crohn's disease (CD), these display an activated Th17 phenotype, as indicated by increased expression interleukin (IL)-17, IL-22, IL-23 receptor. from CD patients readily produce...
Prostaglandins, particularly prostaglandin E2 (PGE2), play an important role during inflammation. This is exemplified by the clinical use of cyclooxygenase 2 inhibitors, which interfere with PGE2 synthesis, as effective antiinflammatory drugs. Here, we show that directly promotes differentiation and proinflammatory functions human murine IL-17-producing T helper (Th17) cells. In purified naive cells, acts via receptor EP2- EP4-mediated signaling cyclic AMP pathways to up-regulate IL-23 IL-1...
Abstract IL-27 is secreted by APCs in response to inflammatory stimuli and exerts a proinflammatory Th1-enhancing activity but also has significant anti-inflammatory functions. We examined the molecular mechanism which regulates TGFβ plus IL-6- or IL-23-dependent Th17 development mouse human systems. inhibited production of IL-17A IL-17F naive T cells suppressing, STAT1-dependent manner, expression Th17-specific transcription factor RORγt. The vivo significance role was addressed...
Keratinocytes play a crucial role in the regulation of skin inflammation, responding to environmental and immune cells stimuli. They produce soluble factors that can act an autocrine or paracrine manner on directly aggressors. A screening activities 36 cytokines keratinocyte gene expression identified IL-17A, IL-22, oncostatin M, TNF-alpha, IL-1alpha as potent inducing cutaneous inflammation. These five proinflammatory synergistically increased production CXCL8 beta-defensin 2 (BD2). In...
Summary Interleukin (IL)-22 is a T cell-derived cytokine that has been reported recently to induce cutaneous inflammation in an experimental murine model of psoriasis, and vitro inflammatory-like phenotype. In the present study, we assessed presence IL-22 receptor 1 (IL-22R1) skin lesions, skin-derived cells, as well levels sera from patients with psoriasis. IL-22R1 IL-10R2 transcripts are expressed at similar level psoriatic healthy skin. contrast, mRNA expression was up-regulated lesions...
Abstract Th17 cells have been named after their signature cytokine IL-17 and accumulating evidence indicates involvement in the induction progression of inflammatory diseases. In addition to single-producing T cells, IL-17/IFN-γ double-positive are found significantly elevated numbers inflamed tissues or blood from patients with chronic disorders. Because IFN-γ is classical Th1-associated cytokine, origin roles these subsets remain elusive. this paper, we show that not only IL-17+/IFN-γ+ but...
Cutaneous inflammatory diseases such as psoriasis vulgaris and atopic dermatitis are associated with altered keratinocyte function, well a particular cytokine production profile of skin-infiltrating T lymphocytes. In this study we show that normal human epidermal keratinocytes express functional type II oncostatin-M (OSM) receptor (OSMR) consisting the gp130 OSMRbeta components, but not I OSMR. The OSMR is expressed in skin lesions from both psoriatic patients those dermatitis. Its ligand,...
Summary Immune‐mediated responses are consistently observed in progressing vitiligo at the edge of depigmenting patches. Besides role adaptive immune system, profile innate response is now center stage. We report that plasmacytoid dendritic cells ( pDC ), which major interferon IFN )‐alpha‐producing cells, part infiltrate progressive with local production MxA (a protein induced by α ). was associated expression type I ‐inducible ligand CXCL 9 and correlated recruitment CXCR 3 + cells....
Programmed cell death 1 (PD-1) is a premier cancer drug target for immune checkpoint blockade (ICB). Because PD-1 receptor inhibition activates tumor-specific T-cell immunity, research has predominantly focused on T-cell-PD-1 expression and its immunobiology. In contrast, cell-intrinsic functional regulation not well understood. Here, we demonstrate induction of in melanoma cells via type I interferon (IFNAR) signaling reversal ICB efficacy through IFNAR pathway inhibition. Treatment with...
Vitiligo is a chronic autoimmune disorder leading to skin depigmentation and reduced quality of life (QOL). Patients with extensive very active disease are the most difficult treat. To assess efficacy adverse events baricitinib combined narrowband UV-B in adults severe, active, nonsegmental vitiligo. This academic, multicenter, double-blind, noncomparative randomized clinical trial was conducted at 4 dermatology departments between July 2021 April 2023 included adult patients The study...
Interleukin-23 (IL-23) is essential for the differentiation of pathogenic effector T helper 17 (Th17) cells, but its role in memory Th17 cell responses unclear. Using experimental autoimmune encephalomyelitis (EAE) model, we report that cells rapidly expanded response to rechallenge and migrated CNS high numbers, resulting earlier onset increased severity clinical disease. Memory were generated from IL-17+ RORγt+ precursors, stability phenotype depended on amount time allowed primary...
Plasmacytoid dendritic cells (pDCs) are a subset of specialized in the production type I interferon (IFN-α/β) and involved various cutaneous inflammatory autoimmune disorders, such as lupus erythematosus (CLE) vitiligo. Heat shock proteins (HSPs) molecular chaperones essential for maintaining cellular functions, but they can act danger signal during inflammation.To decipher role HSP70 IFN-α by pDCs CLE vitiligo.Expression CD123+ was analysed immunohistochemistry or immunofluorescence...