A5003951398- Toxoplasma gondii Research Studies
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Psoriasis: Treatment and Pathogenesis
- Parasitic Infections and Diagnostics
- Research on Leishmaniasis Studies
- IL-33, ST2, and ILC Pathways
- Cytokine Signaling Pathways and Interactions
- Whipple's Disease and Interleukins
- NF-κB Signaling Pathways
- interferon and immune responses
- Inflammasome and immune disorders
- CAR-T cell therapy research
- Trypanosoma species research and implications
- Mycobacterium research and diagnosis
- Crystallography and molecular interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Immunotherapy and Biomarkers
- Atherosclerosis and Cardiovascular Diseases
University of Pennsylvania
2016-2025
California University of Pennsylvania
2015-2025
Philadelphia University
2024
South University
1998-2023
University of Cambridge
1991-2022
University of Maryland, Baltimore
2018
Orlando Regional Medical Center
2016
Orlando Health
2016
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2015
National Institutes of Health
2015
Activated CD8 + T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if key regulatory transcription factor unites the effector functions of cells. We now show that Eomesodermin ( Eomes ), paralogue T-bet , induced vitro vivo. Ectopic expression was sufficient to invoke attributes cells, including interferon-γ (IFN-γ), perforin, granzyme B. Loss-of-function analysis suggests may also be necessary for full differentiation suggest...
The lamprey holds the clue to link between supramolecular self-assembly and allosteric ligand binding. Chelate cooperativity in self-assembled structures results denaturation behavior that is indistinguishable from chelate effect most common origin of positive cooperativity, yet its significance has been widely overlooked. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available...
Organic synthesis is one of the key stumbling blocks in medicinal chemistry. A necessary yet unsolved step planning solving forward problem: Given reactants and reagents, predict products. Similar to other work, we treat reaction prediction as a machine translation problem between simplified molecular-input line-entry system (SMILES) strings (a text-based representation) reactants, We show that multihead attention Molecular Transformer model outperforms all algorithms literature, achieving...
Potent CD19-directed immunotherapies, such as chimeric antigen receptor T cells (CART) and blinatumomab, have drastically changed the outcome of patients with relapsed/refractory B cell acute lymphoblastic leukemia (B-ALL). However, CD19-negative relapses emerged a major problem that is observed in approximately 30% treated patients. Developing approaches to preventing treating antigen-loss escapes would therefore represent vertical advance field. Here, we found primary patient samples, IL-3...
The marriage between immunology and cytometry is one of the most stable productive in recent history science. A rapid search PubMed shows that, as July 2017, using "flow immunology" a term yields more than 68 000 articles, first which, interestingly, not about lymphocytes. It might be stated after short engagement, exchange wedding rings officially occurred when idea to link fluorochromes monoclonal antibodies came about. After this, recognizing different types cells became relatively easy...
Previous studies demonstrate that aluminium hydroxide adjuvant (alum) produces increased Th1 responses in IL-4-deficient mice compared with wild-type animals, although the continued production of IL-5 by spleen cells from these also indicates Th2 are induced. In present study, we alum can induce Th2-associated IL-4 and absence signaling deficient either IL-4Ralpha or Stat6. The observed could not be due to IL-13 as impaired IL-4Ralpha- Stat6-deficient mice. We detected higher levels...
The antitumor effect and mechanisms activated by murine IL-12 IL-18, cytokines that induce IFN-gamma production, were studied using engineered SCK mammary carcinoma cells. In syngeneic A/J mice, cells expressing mIL-12 or mIL-18 less tumorigenic formed tumors more slowly than control Neither SCK.12 nor SCK.18 protected significantly against tumorigenesis distant However, inoculation of the two cell types together synergistically 70% mice from concurrently injected 30% established 3 d...
Neutralizing CXCL10 reverses established vitiligo.
When intracellular pathogens invade mammalian hosts, naïve CD8 + T cells differentiate into cytotoxic killers, which lyse infected target and secrete cytokines that activate microbicides. We show deficient in the transcription factors T-bet eomesodermin (Eomes) fail to functional killers required for defense against lymphocytic choriomeningitis virus. Instead, virus-specific lacking both Eomes an interleukin-17–secreting lineage, reminiscent of helper cell fate has been implicated...