A5085718942- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Chemokine receptors and signaling
- Phagocytosis and Immune Regulation
- Neurogenesis and neuroplasticity mechanisms
- Single-cell and spatial transcriptomics
- Cell Adhesion Molecules Research
- Immune responses and vaccinations
- NF-κB Signaling Pathways
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Peripheral Neuropathies and Disorders
- Atherosclerosis and Cardiovascular Diseases
- interferon and immune responses
- Nerve injury and regeneration
- CRISPR and Genetic Engineering
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research
Weizmann Institute of Science
2016-2025
Robert Bosch (Germany)
2023
University of Mannheim
2019
University Medical Center Hamburg-Eppendorf
2014
Universität Hamburg
2014
University of Freiburg
2013
University Hospital of Lausanne
2009
Cancer Research UK
2009
European Institute of Oncology
2009
Universität Ulm
2009
The seven-transmembrane receptor CX3CR1 is a specific for the novel CX3C chemokine fractalkine (FKN) (neurotactin). In vitro data suggest that membrane anchoring of FKN, and existence shed, soluble FKN isoform allow both adhesive chemoattractive properties. Expression on activated endothelium neurons defines as potential target therapeutic intervention in inflammatory conditions, particularly central nervous system diseases. To investigate physiological function CX3CR1-FKN interactions, we...
Sequencing of RNA from thousands individual immune cells allows unbiased identification cellular subtypes.
Dendritic cells (DCs) and macrophages are critical to innate adaptive immunity the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates entire lamina propria of small intestine. Lamina DCs were found depend on chemokine receptor CX3CR1 form transepithelial dendrites, enable directly sample luminal antigens. was also control clearance entero-invasive pathogens by DCs. Thus, CX3CR1-dependent processes, host interactions specialized with...
Microglia are yolk sac-derived macrophages residing in the parenchyma of brain and spinal cord, where they interact with neurons other glial. After different conditioning paradigms bone marrow (BM) or hematopoietic stem cell (HSC) transplantation, graft-derived cells seed persistently contribute to parenchymal macrophage compartment. Here we establish that acquire, over time, microglia characteristics, including ramified morphology, longevity, radio-resistance clonal expansion. However, even...
Macrophages and dendritic cells (DCs) are crucial for immune inflammatory responses belong to a network of that has been termed the mononuclear phagocyte system (MPS). However, origin lineage these remain poorly understood. Here, we describe isolation clonal analysis mouse bone marrow progenitor is specific monocytes, several macrophage subsets, resident spleen DCs in vivo. It was also possible recapitulate this differentiation vitro by using treatment with cytokines colony-stimulating...
Alum (aluminum hydroxide) is the most widely used adjuvant in human vaccines, but mechanism of its adjuvanticity remains unknown. In vitro studies showed no stimulatory effects on dendritic cells (DCs). absence adjuvant, Ag was taken up by lymph node (LN)–resident DCs that acquired soluble via afferent lymphatics, whereas after injection alum, up, processed, and presented inflammatory monocytes migrated from peritoneum, thus becoming induced a persistent Th2 response. The enhancing alum both...
Opening and closing blood enhancers As cells develop differentiate into different types, the shape accessibility of their DNA can change. Lara-Astiaso et al. studied this phenomenon in blood. They developed a technique that examines relatively small number to identify changes affect during development. found noncoding regions, called enhancers, is set an open position when are undifferentiated able take on variety roles gradually closes as mature final forms. Science , issue p. 943
Although macrophages (MPhi) are known as essential players in wound healing, their contribution to recovery from spinal cord injury (SCI) is a subject of debate. The difficulties distinguishing between different MPhi subpopulations at the lesion site have further contributed controversy and led common view functionally homogenous. Given massive accumulation injured activated resident microglia, which native immune occupants central nervous system (CNS), recruitment additional infiltrating...