Yonit Lavin
A5073819212- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Phagocytosis and Immune Regulation
- Neurogenesis and neuroplasticity mechanisms
- Reproductive System and Pregnancy
- COVID-19 Clinical Research Studies
- Cancer Research and Treatments
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Occupational and environmental lung diseases
- CAR-T cell therapy research
- interferon and immune responses
- Histone Deacetylase Inhibitors Research
- Mercury impact and mitigation studies
- Social Media in Health Education
- MicroRNA in disease regulation
- Advanced Nanomaterials in Catalysis
- Family Support in Illness
- Diagnosis and treatment of tuberculosis
- T-cell and B-cell Immunology
Memorial Sloan Kettering Cancer Center
2022-2025
Howard Hughes Medical Institute
2024
Rockefeller University
2024
Icahn School of Medicine at Mount Sinai
2013-2023
Tisch Cancer Institute
2015-2020
Tisch Hospital
2014-2020
James J. Peters VA Medical Center
2006
Microglia, the brain resident macrophages, critically shape forebrain neuronal circuits. However, their precise function in cerebellum is unknown. Here we show that human and mouse cerebellar microglia express a unique molecular program distinct from microglia. Cerebellar microglial identity was driven by CSF-1R ligand CSF-1, independently of alternate ligand, IL-34. Accordingly, CSF-1 depletion Nestin+ cells led to severe transcriptional alterations microglia, while remained intact....
The COVID-19 pandemic caused by infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to more than 100,000 deaths in the United States. Several studies have revealed that hyper-inflammatory response induced SARS-CoV-2 is a major cause of disease severity and death infected patients. However, predictive biomarkers pathogenic inflammation help guide targetable immune pathways are critically lacking. We implemented rapid multiplex cytokine assay measure serum IL-6,...
Tissue-resident macrophages (TRMs) populate all tissues and play key roles in homeostasis, immunity repair. TRMs express a molecular program that is mostly shaped by tissue cues. However, TRM identity the mechanisms maintain remain poorly understood. We recently found serous-cavity (LPMs) are highly enriched RXR transcripts RXR-response elements. Here, we show RXRs control mouse serous-macrophage regulating chromatin accessibility transcriptional regulation of canonical macrophage genes....
Abstract Background: Diffuse pleural mesothelioma (DPM) is an aggressive malignancy where even patients with potentially resectable disease have poor outcomes. With evolving understanding of the role pleurectomy/decortication (P/D) in disease, need to improve upfront therapies more urgent. In this single institution prospective pilot study nivolumab platinum (cisplatin/carboplatin) and pemetrexed prior P/D (2 cycles) for DPM (NCT04162015), we report clinical outcomes multimodal profiling...
CSF1R (colony stimulating factor 1 receptor) is the main receptor for CSF1 and has crucial roles in regulating myelopoeisis. can be proteolytically released from cell surface by ADAM17 (A disintegrin metalloprotease 17). Here, we identified as a major substrate of an unbiased degradomics screen. We explored impact shedding its upstream regulator, inactive rhomboid protein 2 (iRhom2, gene name Rhbdf2), on homeostatic development mouse myeloid cells. In iRhom2-/- mice, found constitutive...
Abstract: We developed a short questionnaire—Parental PTSD Questionnaire–(PPQ), designed to assess the presence of posttraumatic stress disorder (PTSD) symptoms in parents. Fifty‐eight adult offspring Holocaust survivors (23 men and 35 women) completed questionnaire about parent who was independently evaluated by trained clinician using Clinician Administered Scale (CAPS). Only 5.2% reported, “not knowing” if their had experienced 10 or fewer symptoms, while 56.9% provided estimates for all...
ABSTRACT Here, we leveraged a large neoadjuvant PD-1 blockade trial in patients with hepatocellular carcinoma (HCC) to search for correlates of response immune checkpoint (ICB) within T cell-rich tumors. We show that ICB correlated the clonal expansion intratumoral CXCL13 + CH25H IL-21 CD4 helper cells (CXCL13 Th) and Granzyme K effector-like CD8 cells, whereas terminally exhausted CD39 hi TOX dominated non-responders. Strikingly, most cell receptor (TCR) clones expanded post-treatment were...
Background Mass cytometry leverages inductively coupled mass spectrometry to perform high dimensional single cell analyses using antibodies tagged with rare earth isotopes that are considered be largely absent in biological samples. We have recently noted an unusual exception this rule while analyzing tissue samples from patients undergoing surgical resection for early stage lung cancer, and here we present a detailed cytometric characterization of cerium clinical patient sample. Methods...
8003 Background: Diffuse pleural mesotheliomas (DPM) are an aggressive malignancy where even patients with potentially resectable disease have poor outcomes. With evolving understanding of the role pleurectomy/decortication (P/D) as standard care for disease, need to improve upfront therapies is more urgent. Here we report results our single institution prospective pilot study nivolumab platinum (cisplatin/carboplatin) and pemetrexed prior P/D DPM (NCT04162015). Methods: Patients deemed...
Abstract Microglia, the brain resident macrophages, critically shape forebrain neuronal circuits. However, their precise function in cerebellum is unknown. Here we show that human and mouse cerebellar microglia express a unique molecular program distinct from microglia. Cerebellar microglial identity was driven by CSF-1R ligand CSF-1, independently of alternate ligand, IL-34. Accordingly, CSF-1 depletion Nestin + cells led to severe transcriptional alterations microglia, while remained...
Abstract Tumors form complex ecosystems that include normal epithelial cells, fibroblasts, blood and lymphatic vessels as well structural components, importantly, immune cells. The density, location, organization of various tumor-infiltrating hematopoietic cells myeloid lymphoid origin can impact tumor growth, spreading, clinical outcome cancers, including non-small cell lung cancer (NSCLC). Here, we propose to characterize the microenvironment tumors using a unique set matched fresh tissue...