A5079074289- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- Histiocytic Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
- Virus-based gene therapy research
- Mast cells and histamine
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders Research
- Statistical Methods in Clinical Trials
- Biosimilars and Bioanalytical Methods
- CRISPR and Genetic Engineering
- Cytokine Signaling Pathways and Interactions
Institut Gustave Roussy
2014-2025
Université Paris-Saclay
2017-2025
Inserm
2022-2023
Icahn School of Medicine at Mount Sinai
2016-2023
La Ligue Contre le Cancer
2023
Cancer Institute (WIA)
2020
Tisch Cancer Institute
2020
Tisch Hospital
2020
Hôpital Saint-Louis
2015-2018
Assistance Publique – Hôpitaux de Paris
2014-2018
Abstract We developed a phenotypic screening platform for the functional exploration of dendritic cells (DC). Here, we report genome-wide CRISPR screen that revealed BCL2 as an endogenous inhibitor DC function. Knockout enhanced antigen presentation and activation well capacity DCs to control tumors synergize with PD-1 blockade. The pharmacologic inhibitors venetoclax navitoclax phenocopied these effects caused cDC1-dependent regression orthotopic lung cancers fibrosarcomas. Thus, solid...
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207+ dendritic cells (DCs) with constitutively activated mitogen-activated protein kinase (MAPK) pathway signaling. Approximately 60% of LCH patients harbor somatic BRAFV600E mutations localizing to DCs within lesions. However, the mechanisms driving BRAFV600E+ accumulation in remain unknown. Here we show that sustained extracellular signal–related...
Lymphoma-associated haemophagocytic syndrome (LAHS) accounts for most cases of secondary (HS) and has been extensively described in Asian populations. However, little is known about the epidemiology LAHS Western countries. We herein report a case series 71 patients which lymphomas were mainly aggressive type. Diagnoses included non-Hodgkin B cell lymphoma (46·5%) including human herpes virus 8-associated (12·7%), T (28·2%) Hodgkin (23·9%). An underlying immunodeficiency was 30 (42·3%). Early...
Summary Hodgkin lymphoma (HL) is one of the most common cancers in adolescents and young adults (AYA). Paediatric adult therapeutic strategies diverge while sharing objective: maintaining optimal efficacy with less long‐term toxicity. However, few studies have compared outcome AYA treated according to or other approaches. Among 148 patients aged 15–25 years, at Saint‐Louis Hospital for newly diagnosed HL between 2012 2018, 71 were an protocol 77 a paediatric one. The 5‐year overall survival...
Malignant histiocytoses (MH) are rare and poorly understood cancers, with no established therapeutic guidelines. We conducted a national retrospective study of MH diagnosed in France between 2000 2023. All cases underwent centralized histological review, several malignant tumors stroma highly enriched histiocytes were excluded. In total, 141 patients included, median age 62 years (range, 1 to 87 years). The comprised either primary (64%) or associated other hematologic malignancies (36%)....
Abstract Vaccination against coronavirus disease 2019 (COVID-19) relies on the in-depth understanding of protective immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We characterized polarity and specificity memory T cells directed SARS-CoV-2 viral lysates peptides determine correlates with spontaneous, virus-elicited, or vaccine-induced protection COVID-19 in disease-free cancer-bearing individuals. A disbalance between type 1 2 cytokine release was...
We investigated infectious complications and the associated risk factors in 181 patients undergoing T-cell engagers for malignancies. Infections were primarily observed with hematological diseases or heavily pre-treated. Mortality due to was 2.8%. Concomitant medications corticosteroids tocilizumab did not significantly impact incidence of infections.
The SARS-CoV-2 pandemic still represents a threat for immunosuppressed and hematological malignancy (HM) bearing patients, causing increased morbidity mortality. Given the low anti-SARSCoV-2 IgG titers post-vaccination, COVID-19 prompted prophylactic use of engineered anti-SARS-CoV-2 monoclonal antibodies. In addition, potential clinical significance T cell responses has been overlooked during first waves pandemic, calling additional in-depth studies. We reported that polarity repertoire...
Background: Resistance to anti-PD-1 remains a considerable clinical challenge for the treatment of patients with classical Hodgkin lymphoma (cHL), and mechanisms resistance remain unknown. This pilot study aims investigate tumor microenvironment in cHL relapsing after anti-PD-1. Methods: investigated samples eight cHL, including four exposed paired longitudinal histological analysis before anti-PD-1, not who served as control cellular biological investigations. Fresh cells included...
Chronic neutrophilic leukemia (CNL) is a BCR::ABL1-negative myeloproliferative neoplasm (MPN) characterized by sustained peripheral blood (PB) neutrophilia (white cell count ≥ 25×109/L, with ≥80% neutrophils), bone marrow (BM) hypercellularity due to granulocyte proliferation without excess of blast or dysplasia. Somatic mutations CSF3R gene, encoding the colony stimulating factor (G-CSF) receptor protein, are detected in >60% cases and have significantly helped confirm CNL diagnosis. Two...
// Camille Bigenwald 1 , Jacques-Emmanuel Galimard 2 Laurent Quero 3 Aurélie Cabannes-Hamy 4 Catherine Thieblemont Nicolas Boissel and Pauline Brice Department of Onco-Hematology, Hôpital Saint Louis, Assistance Publique des Hôpitaux de Paris (AP-HP), Université Paris, France Biostatistics Medical Information (ECSTRA Team), Center Research in Epidemiology Statistics Sorbonne, Inserm UMR 1153, Diderot, Radiation Oncology, AP-HP, Hematology Adolescents Young Adults Unit, Saint-Louis,...
Histopathologic diagnosis and treatment of ovarian anaplastic ependymoma are challenging.A 61-year-old-woman presented with a 10-cm right adnexal tumor associated peritoneal carcinomatosis extending to the diaphragm liver surface. After initial papillary serous carcinoma, we performed extensive but nonoptimal cytoreductive surgery including hysterectomy bilateral oophorectomy. Histology revealed some axially arranged cells prominent fibrillary cytoplasm, suggesting an ependymoma. Diagnosis...
Advances in molecular profiling of newly diagnosed diffuse large B-cell lymphoma (DLBCL) have recently refine genetic subgroups. Genetic subgroups remain undetermined at the time relapse or refractory (RR) disease. This study aims to decipher and search for prognostic biomarkers patients with RR-DLBCL. From 2015 2021, targeted next-generation sequencing analyses germline-matched tumor samples fresh tissue from RR-DLBCL were performed. Unsupervised clustering somatic mutations was performed...
Aim: Anti-CD20 monoclonal antibody is a cornerstone therapy for follicular lymphoma. Following anti-CD20 therapy, potential decrease in CD20 antigen, and therefore loss of the tumor target might be expected. However, incidence clinical significance on cells patients with relapsed or refractory lymphoma are unknown. This study aims to investigate outcome harboring target, CD20. Methods: All consecutive adult referred Early Drug Department at Gustave Roussy were included. The main objectives...