A5045685914- Autoimmune and Inflammatory Disorders Research
- Autoimmune Bullous Skin Diseases
- Drug-Induced Adverse Reactions
- Adrenal Hormones and Disorders
- Systemic Lupus Erythematosus Research
- Urticaria and Related Conditions
- Eosinophilic Disorders and Syndromes
- Parvovirus B19 Infection Studies
- Immune Cell Function and Interaction
- Inflammatory Myopathies and Dermatomyositis
- Pituitary Gland Disorders and Treatments
- Vasculitis and related conditions
- Viral-associated cancers and disorders
- Nail Diseases and Treatments
- Asthma and respiratory diseases
- Family and Disability Support Research
- Autoimmune and Inflammatory Disorders
- Nuclear Structure and Function
- HIV-related health complications and treatments
- Diabetes and associated disorders
- Pharmacovigilance and Adverse Drug Reactions
- Sarcoidosis and Beryllium Toxicity Research
- Adolescent and Pediatric Healthcare
- Health, Medicine and Society
- Drug-Induced Ocular Toxicity
Hôpital Saint-Antoine
2008-2021
Sorbonne Université
2008-2021
Université Paris-Est Créteil
2008-2021
Centre Hospitalier Universitaire Henri-Mondor
2005-2021
Assistance Publique – Hôpitaux de Paris
2010-2021
Hôpitaux Universitaires Henri-Mondor
2015-2021
University College London
2011-2020
Epidemiology in dermatology and evaluation of therapeutics
2018
Société Française de Cardiologie
2018
Université Paris Cité
2003-2015
Because it has no unique clinical, biologic, or histologic features, reactive hemophagocytic syndrome may be difficult to distinguish from other diseases such as severe sepsis hematologic malignancies. This study was undertaken develop and validate a diagnostic score for syndrome.A multicenter retrospective cohort of 312 patients who were judged by experts have (n = 162), not 104), in whom the diagnosis undetermined 46) used construct score, called HScore. Ten explanatory variables evaluated...
Objective. To assess trends in long-term (i.e. ≥3 months) oral glucocorticoid (GC) prescriptions over the past 20 years. Methods. Data of UK adult patients registered between January 1989 and December 2008 with general practices contributing to The Health Improvement Network (THIN) database were obtained. annual prevalence GC was assessed whole population specifically people RA, PMR/GCA, asthma, chronic obstructive pulmonary disease (COPD), Crohn's ulcerative colitis (UC). Trends 20-year...
An epidemiological study of British general practice patients who received oral glucocorticoids showed that these drugs were seven times as likely to attempt suicide with the same illness did not receive steroids. The increase was most prominent in younger people. Mania and delirium also significantly more common, particularly older men. Neuropsychiatric effects common receiving higher doses those previous mental disorders.
Glucocorticoids are the most commonly prescribed anti-inflammatory/immunosuppressant medications worldwide. This article highlights risk of clinically significant and sometimes severe psychological, cognitive, behavioral disturbances that may be associated with glucocorticoid use, as well ways to prevent treat these disturbances. An illustrative case vignette is presented describing a patient’s experience cycles manic-like behavior depression while on high-dosage prednisone, long-term...
Summary Reactive haemophagocytic syndrome is a life‐threatening disease for which factors influencing the outcome remain unclear. We sought to identify determinants of early mortality in patients with reactive by conducting non‐interventional retrospective multicentre study three tertiary care teaching hospitals over 6‐year period. The medical files 162 fulfilling our diagnostic criteria were reviewed. Patients classified according 30‐d following diagnosis. Thirty‐three (20·4%) died within...
More than 50 years after the introduction of corticosteroids, few studies have focused on corticosteroid-induced adverse events long-term systemic therapy.To assess frequency, risk factors and patient's opinion regarding clinical occurring early during prednisone therapy.We conducted a cohort study in two French centres. All consecutive patients starting (> oir = 3 months), high dosage or 20 mg day(-1)) therapy were enrolled. The main attributable to corticosteroids assessed months therapy,...
Little is known about the relative risk of common bacterial, viral, fungal, and parasitic infections in general population individuals exposed to systemic glucocorticoids, or impact glucocorticoid exposure duration predisposing factors on this risk.The hazard ratios various were assessed 275,072 adults prescribed glucocorticoids orally for ≥15 d (women: 57.8%, median age: 63 [interquartile range 48-73] y) comparison those not glucocorticoids. For each infection, incidence rate calculated...
Demographic, clinical, and laboratory features that predict underlying malignancy in patients with dermatomyositis (DM) are poorly known. We conducted a retrospective study all adult definite (n = 75) or probable 32) diagnosis of DM according to Bohan Peter criteria amyopathic 14) who were referred 2 departments during 13-year period. The malignancy-associated was retained if occurred context recently diagnosed the 5 years following DM. Kaplan-Meier method used assess cumulative incidence...
<h3>Objective</h3> The value of surveillance for patients with Barrett9s oesophagus (BO) is under discussion given the overall low incidence neoplastic progression and lack discriminative tests risk stratification. Histological diagnosis low-grade dysplasia (LGD) only accepted predictor to date, but has a predictive value. aim this study was therefore evaluate p53 immunohistochemistry predicting in BO. <h3>Design</h3> We conducted case–control within prospective cohort 720 Patients who...
To study trends in use of oral glucocorticoids (GCs) among adults, characteristics GC initiators and prescriptions for the prevention potential adverse effects associated with therapy.First, a cross-sectional repeated yearly was performed from 2007 to 2014 nationwide representative sample. Second, patterns therapy during year following treatment initiation were described cohort patients who began between 2013.Population-based using data French reimbursement healthcare system (covering...
Objective: To describe features of reactive haemophagocytic syndrome (RHS) in HIV-1-infected adult patients. compare characteristics patients with malignancy-associated RHS and infection-associated RHS. Design Setting: Retrospective study three departments Infectious Diseases/Internal Medicine at French tertiary centres. Patients methods: Medical charts seen between January 2006 December 2007 were reviewed. Demographic, clinical laboratory data obtained the time episode compared using...
The diagnosis of the reactive form hemophagocytic syndrome in adults remains particularly difficult since none clinical or laboratory manifestations are specific. We undertook a study order to elicit which features constitute helpful criteria for positive diagnosis. In this Delphi study, investigated questionnaire and experts invited participate survey were issued from bibliographic search. was iteratively proposed via web-based application with feedback results observed at preceding round....
Epidermal necrolysis (EN) encompasses Stevens-Johnson syndrome (SJS, < 10% of the skin affected), Lyell (toxic epidermal necrolysis, TEN, with ≥30% affected) and an overlap (10 to 29% affected). These rare diseases are caused, in 85% cases, by pharmacological treatments, symptoms occurring 4 28 days after treatment initiation. Mortality is 20 25% during acute phase, almost all patients display disabling sequelae (mostly ocular impairment psychological distress). The objective this French...
Adult-onset Still disease (AOSD) is a rare systemic inflammatory disorder. A few patients develop organ complications that can be life-threatening. Our objectives were to describe the course and phenotype of life-threatening AOSD, including response therapy long-term outcome. multicenter case series intensive care medicine (ICU) with AOSD systematic literature review. Twenty included. ICU admission mostly occurred at onset (90%). Disease manifestations included fever (100%), sore throat...
A very low percentage of glycosylated ferritin (<20%) has only been reported in association with adult-onset Still's disease (AOSD), a classically associated hemophagocytic syndrome. We undertook this study to determine whether syndrome outside the context AOSD is also ferritin.From October 2006 September 2007, serum level was determined all consecutive patients seen 3 departments and for whom diagnosis suspected. The these compared that age- sex-matched controls marked inflammatory not...
Evidence for the long-term efficacy and safety of anti-tumor necrosis factor α agents (anti-TNF) in treating cutaneous sarcoidosis is lacking.To determine anti-TNF a large observational study.STAT (Sarcoidosis Treated with Anti-TNF) French retrospective prospective multicenter database that receives data from teaching hospitals referral centers, as well several pneumology, dermatology, internal medicine departments. Included patients had histologically proven received between January 2004...
Because of its rarity, the exact incidence and mortality from epidermal necrolysis (Stevens–Johnson syndrome/toxic necrolysis) is difficult to establish closely depends on size type data source. To estimate due in France over a 14‐year period. Data four national databases were analysed. A capture–recapture analysis was performed. total 2635 incident cases recorded at least one during study period [males: 47·9%; median age: 52 (interquartile range 25–72) years]. On analysis, estimated number...