A5035640410- Autoimmune Bullous Skin Diseases
- Cutaneous Melanoma Detection and Management
- Psoriasis: Treatment and Pathogenesis
- Urticaria and Related Conditions
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Dermatology and Skin Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Nonmelanoma Skin Cancer Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Acne and Rosacea Treatments and Effects
- Cutaneous lymphoproliferative disorders research
- CAR-T cell therapy research
- Allergic Rhinitis and Sensitization
- Nail Diseases and Treatments
- Skin Diseases and Diabetes
- Autoimmune and Inflammatory Disorders
- Computational Drug Discovery Methods
- Immunodeficiency and Autoimmune Disorders
- Streptococcal Infections and Treatments
- Immunotherapy and Immune Responses
- Hidradenitis Suppurativa and Treatments
- Cancer and Skin Lesions
- Chemotherapy-related skin toxicity
- Skin Protection and Aging
Centre Hospitalier Universitaire de Rennes
2016-2025
Université de Rennes
2016-2025
Inserm
2013-2025
Hôpital Pontchaillou
2014-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2025
Clarivate (United States)
2025
Bureau de Recherches Géologiques et Minières
2024
École des Hautes Études en Santé Publique
2018-2024
Institut de Recherche en Santé, Environnement et Travail
2022-2024
CIC Rennes
2013-2022
<h3>Abstract</h3> <b>Objective:</b> To assess risk factors for erysipelas of the leg (cellulitis). <b>Design:</b> Case-control study. <b>Setting:</b> 7 hospital centres in France. <b>Subjects:</b> 167 patients admitted to and 294 controls. <b>Results:</b> In multivariate analysis, a disruption cutaneous barrier (leg ulcer, wound, fissurated toe-web intertrigo, pressure or dermatosis) (odds ratio 23.8, 95% confidence interval 10.7 52.5), lymphoedema (71.2, 5.6 908), venous insufficiency (2.9,...
Fixed drug eruption (FDE) is one of the most typical cutaneous adverse reactions. This localized drug-induced reaction characterized by its relapse at same sites. Few large series FDE are reported. The aim this study was to retrospectively collect and analyse well informed cases observed in a hospital setting. involved 17 academic clinical centers. A French nation-wide retrospective multicentric carried out on 3-year-period from 2005 2007 collecting data seventeen departments dermatology...
Demographic, clinical, and laboratory features that predict underlying malignancy in patients with dermatomyositis (DM) are poorly known. We conducted a retrospective study all adult definite (n = 75) or probable 32) diagnosis of DM according to Bohan Peter criteria amyopathic 14) who were referred 2 departments during 13-year period. The malignancy-associated was retained if occurred context recently diagnosed the 5 years following DM. Kaplan-Meier method used assess cumulative incidence...
Abstract Background WHIM syndrome (WS), a rare congenital neutropenia due to mutations of the CXCR4 chemokine receptor, is associated with Human Papillomavirus (HPV)-induced Warts, Hypogammaglobulinemia, bacterial Infections and Myelokathexis. The long term follow up eight patients highlights clinical heterogeneity this disease as well main therapeutic approaches remaining challenges in light recent development new inhibitors. Objective This study aims describe natural history WS based on...
<h3>Importance</h3> Ustekinumab, a monoclonal antibody targeting interleukin 12/23p40 (IL-12/23p40), is effective in the treatment of moderate to severe psoriasis, psoriatic arthritis, and Crohn disease. In 2011, meta-analysis randomized clinical trials reported potential risk cardiovascular events (SCEs) within first few months after initiation anti–IL-12/23p40 antibodies. <h3>Objective</h3> To assess whether ustekinumab associated with increased SCEs. <h3>Design, Setting, Participants</h3>...
BackgroundSurgery is the primary treatment for basal cell carcinoma (BCC). In locally advanced (laBCC), surgery may cause functional or aesthetic damage. laBCC, neoadjuvant administration of vismodegib, an inhibitor Hedgehog signaling pathway, reduce tumor size, facilitate resection, and consequences surgery. The VISMONEO study assessed efficacy safety vismodegib in laBCC.MethodsVISMONEO (NCT02667574) open-label, noncomparative, multicenter, phase 2 study. Patients with ≥1 histologically...
<h3>Background</h3> Pemphigus vulgaris (PV) is a severe antibody-mediated autoimmune blistering disease. Because some patients with PV do not enter into remission, despite the use of high-dose corticosteroid therapy and immunosuppressive adjuvant treatments, new effective safer agents are warranted to treat refractory PV. Rituximab, monoclonal anti-CD20 antibody, induces depletion B cells in vivo has shown efficacy disorders. We describe herein 3 treated rituximab for <h3>Observations</h3>...
Upper limb lymphedema occurs in approximately 15-20% of women after breast cancer treatment. We analysed the factors associated with volume.Cross-sectional study 807 patients secondary arm was performed a single lymphology unit. Data collected included patient characteristics, characteristics treatment, past history cellulitis, Body Mass Index, delay from to onset and duration lymphedema. Lymphedema volume calculated for each 5-cm segment by utilizing formula truncated cone. Univariate...
Two pemphigus severity scores, Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Pemphigus Disease Area Index (PDAI), have been proposed to provide an objective measure of disease activity. However, the use these scores in clinical practice is limited by absence cut‐off values that allow differentiation between moderate, significant extensive types pemphigus. To calculate defining based on ABSIS PDAI scores. In 31 dermatology departments six countries, consecutive patients with...
CD95 ligand (CD95L) is expressed by immune cells and triggers apoptotic death. Metalloprotease-cleaved CD95L (cl-CD95L) released into the bloodstream but does not trigger signaling. Hence, pathophysiological role of cl-CD95L remains unclear. We observed that skin-derived endothelial from systemic lupus erythematosus (SLE) patients after cleavage, promoted T helper 17 (Th17) lymphocyte transmigration across barrier at expense regulatory cells. cell migration relied on a direct interaction...
Corticosteroids (CS) with or without adjuvant immunosuppressant agents are standard treatment for pemphigus vulgaris (PV). The efficacy of therapies in minimizing steroid‐related adverse events (AEs) is unproven. To utilize data collected a French investigator‐initiated, phase III, open‐label, randomized controlled trial to demonstrate the and safety rituximab seek approval its use PV. This was an independently conducted post hoc analysis moderate‐to‐severe PV subset enrolled Ritux 3 study....
Rituximab and short-term corticosteroid therapy are the criterion standard treatments for patients with newly diagnosed moderate to severe pemphigus.To examine factors associated relapse in pemphigus treated rituximab.This post hoc analysis of a randomized clinical trial (Comparison Between Treatment Oral Corticosteroid Patients With Pemphigus [RITUX 3]) conducted from January 1, 2010, December 31, 2015, included 20 dermatology departments tertiary care centers France RITUX 3 according...
PURPOSE Emerging evidence suggests a correlation between the tumor mutational burden (TMB) and response to programmed cell death-1 protein (PD-1) monotherapy across multiple cancer types. In skin cancers, as high TMB is mostly because of ultraviolet (UV) exposure, we hypothesized primary melanoma cutaneous location according sun exposure anti–PD-1 monotherapy. METHODS The aim this study was analyze, in advanced melanoma, relationship TMB, locations PD-1 inhibitors. We conducted prospective...
Importance The Ritux 3 trial demonstrated the short-term efficacy and safety of first-line treatment with rituximab compared a standard corticosteroid regimen in pemphigus. No data on long-term follow-up patients who received as first line are available. Objective To assess regimen. Design, Setting, Participants This 7-year study included pemphigus from 25 dermatology departments France January 1, 2010, to December 31, 2015. Exposure Patients were initially randomized plus prednisone group...
VEXAS (Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is caused by acquired somatic mutations in UBA1. Sweet-syndrome-like skin disorders [and especially histiocytoid Sweet (HSS)] may be associated with syndrome.