A5041668518- Pharmacovigilance and Adverse Drug Reactions
- Cardiac electrophysiology and arrhythmias
- COVID-19 Clinical Research Studies
- Drug-Induced Adverse Reactions
- Ion channel regulation and function
- Pharmaceutical studies and practices
- Atrial Fibrillation Management and Outcomes
- Schizophrenia research and treatment
- SARS-CoV-2 and COVID-19 Research
- Cardiac Arrhythmias and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Heart Failure Treatment and Management
- Pharmacogenetics and Drug Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Renal Diseases and Glomerulopathies
- Cancer Immunotherapy and Biomarkers
- Pharmaceutical Economics and Policy
- Cardiovascular Syncope and Autonomic Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Migraine and Headache Studies
- Pharmacology and Obesity Treatment
- Receptor Mechanisms and Signaling
- Epilepsy research and treatment
- Drug-Induced Hepatotoxicity and Protection
- Viral Infections and Immunology Research
Centre Hospitalier Universitaire de Nice
2012-2025
Université Côte d'Azur
1996-2025
Institut de Biologie Valrose
2020-2024
Hôpital Pasteur
2014-2023
Fondation Lenval
2022
Institut de Chimie de Nice
2019
l'Assurance Maladie
2014
Conservatoire National des Arts et Métiers
2013-2014
University of Pittsburgh
2005
Centre National de la Recherche Scientifique
1999-2002
In pharmacovigilance, disproportionality analyses based on individual case safety reports are widely used to detect signals. Unfortunately, publishing lacks specific guidelines, often leading incomplete and ambiguous reporting, carries the risk of incorrect conclusions when data not placed in correct context. The REporting A Disproportionality analysis for drUg Safety signal detection using PharmacoVigilance (READUS-PV) statement was developed address this issue by promoting transparent...
Disproportionality analyses using reports of suspected adverse drug reactions are the most commonly used quantitative methods for detecting safety signals in pharmacovigilance. However, their and results generally poorly reported published articles existing guidelines do not capture specific features disproportionality analyses. We here describe development a guideline (REporting A analysis drUg Safety signal detection individual case PharmacoVigilance [READUS-PV]) reporting abstracts....
Context.—Erythromycin is a widely used antibiotic that infrequently causes QT-prolongation and torsades de pointes cardiac arrhythmias. For antiarrhythmic drugs, women are at higher risk for these arrhythmias, but few other classes of drugs have been studied.Objectives.—To determine whether female sex factor arrhythmias associated with erythromycin, if this can be correlated in vitro measurements the QT-response to erythromycin male rabbit hearts.Design.—Food Drug Administration (FDA)...
<h3>Importance</h3> Ustekinumab, a monoclonal antibody targeting interleukin 12/23p40 (IL-12/23p40), is effective in the treatment of moderate to severe psoriasis, psoriatic arthritis, and Crohn disease. In 2011, meta-analysis randomized clinical trials reported potential risk cardiovascular events (SCEs) within first few months after initiation anti–IL-12/23p40 antibodies. <h3>Objective</h3> To assess whether ustekinumab associated with increased SCEs. <h3>Design, Setting, Participants</h3>...
In the present study, two new peptides, phrixotoxins PaTx1 and PaTx2 (29–31 amino acids), which potently block A‐type potassium currents, have been purified from venom of tarantula Phrixotrichus auratus . Phrixotoxins specifically Kv4.3 Kv4.2 currents that underlie I to1 , with an 5<IC 50 <70 n M by altering gating properties these channels. Neither are Shaker (Kv1), Shab (Kv2) Shaw (Kv3) subfamilies nor HERG, KvLQT1/IsK, inhibited appear specific Shal (Kv4) subfamily also in isolated...
Remdesivir is approved for emergency use by the US Food and Drug Administration (FDA) authorized conditionally European Medicines Agency (EMA) patients with coronavirus disease 2019 (COVID-19). Its benefit-risk ratio still being explored because data in field are rather scant. A decrease of creatinine clearance associated remdesivir has been inconstantly reported clinical trials unclear relevance. Despite these uncertainties, we searched a potential signal acute renal failure (ARF)...
Migraine is responsible for significant disability and societal burden. Recently, drugs targeting the calcitonin gene-related peptide (CGRP) pathway raised new hopes. CGRP, a potent vasodilator, plays key role in pathogenesis of migraine attacks. The deficiency CGRP involved Raynaud's phenomenon, which consists abnormal vasoconstriction digits. We aimed to assess potential association phenomenon with CGRP-targeting drugs, analyzing real-world data from World Health Organization (VigiBase®).
Abstract Aims While some concerns about vaccination-related pericarditis and/or myocarditis have been raised, no published data are available on with mRNA COVID-19 vaccines in the age group of adolescents, particularly 12–15 years. The objective this study was to determine whether risk reporting varied according dose vaccination, age, sex, and type adolescents between 12 17 Methods results We performed an observational reviewing all reports vaccinated recorded VigiBase®, World Health...
To evaluate the prevalence of cardiac toxoplasmosis in a series 182 necropsies performed between 1987 and 1991 on patients infected with human immunodeficiency virus (HIV), to correlate this ante mortem diagnosis involvement, assess role such lesions immediate cause death.Complete HIV-infected (48 women, 134 men) were consecutively 1991. Risk factors, identified 174 cases, included drug abuse (111/182), homosexuality (51/182), blood transfusions (12/182). 16 samples systematically obtained...
Acetylcholine (ACh) is an important neuromodulator of cardiac function that released upon stimulation the vagus nerve. Despite numerous reports on activation I KACh by acetylcholine in cardiomyocytes, it has yet to be demonstrated what role this channel plays conduction. We studied effect tertiapin, a bee venom peptide blocking , evaluate Langendorff preparations challenged with ACh. ACh (0.5 μ M ) reproducibly and reversibly induced complete atrioventricular (AV) blocks retroperfused...
A significant heterogeneity prevails in antipsychotics (APs) safety monitoring recommendations. Youths are deemed more vulnerable to cardiometabolic side effects. We aimed assess age-dependent reporting of cardiac and metabolic disorders youths, relying on the WHO database (VigiBase®). VigiBase® was queried for all reports cardiac, glucose, lipid nutritional involving APs. Patients <18 years were classified as pediatric population. Disproportionality analyses relied Information Component...
The voltage-dependent K + channel responsible for the slowly activating delayed current I Ks is composed of pore-forming KCNQ1 and regulatory KCNE1 subunits, which are mutated in familial forms cardiac long QT syndrome. Because genes also expressed epithelial tissues, such as kidneys intestine, we have investigated adaptation KCNE1-deficient mice to different Na intakes. On a normal diet, homozygous kcne1 −/− exhibit signs chronic volume depletion associated with fecal wasting lower plasma...
Immune checkpoint inhibitors (ICIs) foster anti-cancer immune responses. Their efficacy comes at the cost of immune-related adverse events (IRAEs). The latter affects various organs, including kidneys, mostly as acute tubulointerstitial nephritis, pathophysiology which remains unclear. We conducted a multicentre case-control study to compare characteristics patients with renal IRAEs (ICI-AKI) those diagnosed other IRAEs.We queried French pharmacovigilance database for all involving ICIs....
Rituximab is a first-line treatment for membranous nephropathy. Nephrotic syndrome limits rituximab exposure due to urinary drug loss. underdosing (serum level <2 μg/ml at month-3) risk factor failure. We developed machine learning algorithm predict the of based on patients' characteristics infusion. investigated relationship between predicted and cumulative dose required achieve remission.