A5017322608- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical Practices and Patient Outcomes
- Acute Ischemic Stroke Management
- Drug-Induced Adverse Reactions
- Pharmaceutical studies and practices
- Health, Medicine and Society
- Heparin-Induced Thrombocytopenia and Thrombosis
- Pharmaceutical Economics and Policy
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Healthcare Systems and Practices
- Autoimmune Bullous Skin Diseases
- Health Systems, Economic Evaluations, Quality of Life
- SARS-CoV-2 and COVID-19 Research
- Atrial Fibrillation Management and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Poisoning and overdose treatments
- Lipoproteins and Cardiovascular Health
- Contact Dermatitis and Allergies
- Botulinum Toxin and Related Neurological Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Neuropathies and Disorders
- Dementia and Cognitive Impairment Research
- Maternal Mental Health During Pregnancy and Postpartum
- Pneumocystis jirovecii pneumonia detection and treatment
- S100 Proteins and Annexins
Université de Lille
2015-2024
Inserm
2015-2024
Centre Hospitalier Universitaire de Lille
2015-2024
Brain Physiology Lab
2024
Centre de Recherche Jean Pierre Aubert
2022-2024
Lille Neurosciences & Cognition
2020-2023
Centre Oscar Lambret
2022
Silios Technologies (France)
2008-2021
Laboratoire de Biophotonique et Pharmacologie
2014-2021
European Genomic Institute for Diabetes
2020
To determine whether higher neutrophil counts before IV recombinant tissue plasminogen activator (rtPA) administration in ischemic stroke (IS) patients are associated with symptomatic intracerebral hemorrhages (sICH) and worse outcomes at 3 months.Blood samples for leukocyte, neutrophil, lymphocyte were drawn rtPA IS included the cohorts of Lille Helsinki. The primary endpoint was sICH (European Cooperative Acute Stroke-II definition). Secondary endpoints death excellent (modified Rankin...
Inhibitors of dipeptidyl peptidase (DPP)‐IV have been suspected in the onset bullous pemphigoid for several years now. However, comparative studies assessing link between DPP‐IV inhibitor exposure and not yet performed. To detect, from French Pharmacovigilance Database (FPVD), a signal risk during by study. All spontaneous reports inhibitor‐related recorded FPVD April 2008 August 2014 were described. We conducted disproportionality analyses (case–noncase method) to assess inhibitors...
Background and Purpose— Orolingual angioedema (OLAE) is a life-threatening complication of intravenous thrombolysis. Our objective was to compare outcomes patients with without OLAE. Methods— We prospectively included consecutive who received thrombolysis for cerebral ischemia at Lille University Hospital. examined tongue lips every 15 minutes during ≤30 after. evaluated the 3-month outcome modified Rankin scale (mRS) compared Results— Of 923 patients, 20 (2.2%) developed None them needed...
In the last French study in 2007, incidence of hospital admissions (HAs) related to adverse drug reactions (ADRs) was 3.6%. The objective assess current ADR-HA France and describe both its characteristics preventability.A prospective multicentre conducted among randomly selected public medical wards (April-July 2018). Patients admitted during a week period were included. cases collected by Regional Pharmacovigilance Centres network. An independent committee validated potential ADR...
We conducted a national in-depth analysis including pharmacovigilance reports and clinical study to assess the reporting rate (RR) determine profile of polymyalgia rheumatica (PMR) giant cell arteritis (GCA) in COVID-19-vaccinated individuals. First, based on French database, we estimated RR PMR GCA cases individuals aged over 50 who developed their initial symptoms within one month receiving BNT162b2 mRNA, mRNA-1273, ChAdOx1 nCoV-19, Ad26.COV2.S vaccines. then nationwide survey gather...
To report three cases of bullous pemphigoid in patients treated with vildagliptin. Case 1: An 86-year-old woman presented after 1 month treatment vildagliptin and metformin. After introduction clobetasol, the symptoms resolved although was continued. However, skin lesions reappeared 3 months later. Sustained remission achieved only definitive withdrawal 2: A 79-year-old man 37-month gliclazide, The disease at first responded to clobetasol but later reappeared. They finally regressed when...
In stroke, there is an imperative need to develop disease-modifying drugs able (1) induce neuroprotection and vasculoprotection, (2) modulate recovery brain plasticity, (3) limit the short-term motor cognitive consequences. We hypothesized that fenofibrate, a peroxisome proliferator-activated receptor- α (PPAR- α) agonist, could exert beneficial effect on immediate poststroke consequences related its pleiotropic mechanisms. Rats or mice were subjected focal ischemia determine effects of...
<h3>Objective</h3> In acute cerebral ischemia, circulating neutrophil count and neutrophil-to-lymphocyte ratio (NLR) are positively associated with stroke severity worse outcomes. Mediators of this effect unknown. We aimed to investigate (1) the relationship between plasma matrix metalloproteinase-9 (MMP-9) myeloperoxidase (MPO) concentrations outcome (2) MMP-9 MPO release after ex vivo stimulation neutrophils by recombinant tissue plasminogen activator (rtPA). <h3>Methods</h3> analyzed data...
A better understanding of immune-related adverse events is essential for the early detection and appropriate management these phenomena. We conducted an observational study cases recorded at French reference center hypereosinophilic syndromes in national pharmacovigilance database. Thirty-seven reports eosinophilia induced by treatment with immune checkpoint inhibitors (ICIs) were included. The median [range] time to absolute eosinophil count (AEC) peak was 15 [4─139] weeks. AEC 2.7...
Abstract Aims While some concerns about vaccination-related pericarditis and/or myocarditis have been raised, no published data are available on with mRNA COVID-19 vaccines in the age group of adolescents, particularly 12–15 years. The objective this study was to determine whether risk reporting varied according dose vaccination, age, sex, and type adolescents between 12 17 Methods results We performed an observational reviewing all reports vaccinated recorded VigiBase®, World Health...
Zoledronic acid-associated renal impairment leading to failure has been recently reported in a cohort of US patients. However, the presence such toxicity other populations not yet determined.To analyze French cases zoledronic nephrotoxicity.We evaluated available with acute deterioration function associated acid therapy drawn from Adverse Event Reporting System database until July 1, 2004.We identified 4 men and 3 women between ages 52 70 years, multiple myeloma or different types metastatic...
Background and purpose: Polymorphonuclear neutrophils (PMNs) contribute to the vascular damage caused by transient cerebral ischaemia. Here we have evaluated role of PMNs in intracerebral haemorrhage (ICH) induced a model thrombolysis with recombinant tissue plasminogen activator (t‐PA) during acute phase Experimental approach: The middle artery (MCA) male spontaneously hypertensive rats was occluded for 1 h followed reperfusion and, 5 later, infusion thrombolytic products (generated vitro...
To determine whether low low-density lipoprotein cholesterol (LDL-C) but not high-density (HDL-C) and triglyceride concentrations are associated with worse outcome in a large cohort of ischemic stroke patients treated IV thrombolysis.Observational multicenter post hoc analysis prospectively collected data thrombolysis registries. Because collinearity between total (TC) LDL-C, we used 2 different models TC (model 1) LDL-C 2).Of the 2,485 consecutive patients, 1,847 (74%) had detailed lipid...
The community pharmacist is a key player in medication reviews of older outpatients. However, it not always clear which individuals require review. objective the present study was to identify high-priority patients for intervention by pharmacist.As part their final-year placement pharmacy, pharmacy students conducted 10 interviews each with adults (aged 65 or over) taking at least five medications daily. student interviewer also offered examine patient's home medicine cabinet. An interview...
Although several case series have described nitrous-oxide-associated neurological disorders, a comprehensive assessment of exposure characteristics (e.g., time to onset, level exposure) in substance abusers has not been performed. The aim this study was describe the onset patterns recreational use nitrous-oxide-induced disorders. All cases disorders related nitrous oxide reported Hauts-de-France addictovigilance center between January 2019 and August 2020 were selected. Only requiring...
Granulocyte colony-stimulating factor (G-CSF) is a pharmacologic agent inducing neutrophil mobilization and new candidate for neuroprotection neuroregeneration in stroke. Its effects when used combination with tissue plasminogen activator (tPA) were explored during the acute phase of ischemic We middle cerebral artery occlusion (MCAO) model ischemia, associated treatment tPA, male spontaneously hypertensive rats (SHR). (G-CSF; 60 μg/kg) was injected just before tPA. Neutrophil response...