A5102779379- Health, Medicine and Society
- Lipoproteins and Cardiovascular Health
- Peroxisome Proliferator-Activated Receptors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Antioxidant Activity and Oxidative Stress
- Atherosclerosis and Cardiovascular Diseases
- Paraoxonase enzyme and polymorphisms
- Eicosanoids and Hypertension Pharmacology
- Free Radicals and Antioxidants
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Cynara cardunculus studies
- Circadian rhythm and melatonin
- Nitric Oxide and Endothelin Effects
- Diet, Metabolism, and Disease
- Blood Pressure and Hypertension Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Phytochemicals and Antioxidant Activities
- Hormonal Regulation and Hypertension
- Biochemical Acid Research Studies
- Pancreatitis Pathology and Treatment
- Neurological Disease Mechanisms and Treatments
Inserm
2001-2019
Université de Lille
2003-2019
Centre Hospitalier Universitaire de Lille
1999-2019
Institut Pasteur
1991-2016
Université Lille Nord de France
2011-2014
University Hospital of Basel
2012
University Hospital of Zurich
2012
Predict (France)
2010-2011
Institut Pasteur de Lille
1999-2008
Centre d’Investigation Clinique Innovation Technologique de Nancy
2005
Abstract —Endothelin-1 (ET-1), a 21-amino acid vasoactive peptide mainly produced by vascular endothelial cells, is involved in the regulation of tone and smooth muscle cell proliferation. Peroxisome proliferator-activated receptors (PPARs), key players lipid glucose metabolism, have been implicated metabolic disorders that are predisposing to atherosclerosis. Because potential role ET-1 such as hypertension atherosclerosis, we investigated expression PPAR activators. Western blot reverse...
The treatment of ischemic strokes is limited to the prevention cerebrovascular risk factors and modulation coagulation cascade during acute phase. A new therapeutic strategy could be preventively protect brain against noxious biological reactions induced by cerebral ischemia such as oxidative stress inflammation minimize their neurological consequences. Here, we show that a peroxisome proliferator-activated receptor (PPAR-α) activator, fenofibrate, protects injury anti-oxidant...
The peroxisome proliferator‐activated receptor α (PPARα) is a transcription factor belonging to the PPAR subfamily of nuclear receptors. Fatty acids and eicosanoids are natural PPARα ligands. Here, we show using transient transfection assays that oxidized (oxLDL) but not native low‐density lipoproteins (LDL) dose‐dependently activate in endothelial cells without affecting protein expression. Fractioning oxLDL lipids followed by transactivation experiments demonstrated phospholipid component...
Background —Monocytic tissue factor (TF) expression may contribute to thrombogenicity associated with plaque rupture and propagate thrombus formation at the site of vascular lesions. Induction monocytic TF by endotoxin is mediated activation transcription factors such as AP-1 NF-κB. Both these signaling pathways are modulated peroxisome proliferator–activated receptor-α (PPARα). Therefore, we have studied effects fibrates other PPARα agonists on TF. Methods Results —We show that protein,...
In stroke, there is an imperative need to develop disease-modifying drugs able (1) induce neuroprotection and vasculoprotection, (2) modulate recovery brain plasticity, (3) limit the short-term motor cognitive consequences. We hypothesized that fenofibrate, a peroxisome proliferator-activated receptor- α (PPAR- α) agonist, could exert beneficial effect on immediate poststroke consequences related its pleiotropic mechanisms. Rats or mice were subjected focal ischemia determine effects of...
Endothelin is a potent vasoconstrictor peptide isolated from endothelial cells and it induces smooth muscle cell proliferation. Endothelin-1 secretion increased in atheroma deleterious effects such as vasospasm atherosclerosis. Oxidized low-density lipoproteins (LDLs) induce atherosclerosis the vascular wall, well endothelin-1 are activators of both peroxisome proliferator-activated receptor-alpha (PPAR-alpha) PPAR-gamma. PPAR-alpha (fibric acids) PPAR-gamma (glitazones) used to treat...
This study attempted to determine if low density lipoproteins (LDL) induce the production of endothelins (ET) by human macrophages. Non-protected LDL from macrophage induced oxidation (n-LDL), copper-oxidized (Ox-LDL), acetylated-LDL (Ac-LDL), butylated hydroxytoluene-LDL (BHT-LDL), BHT-Ac-LDL, polyinosinic acid (PiA, 1.5 micrograms/ml), phorbol myristate acetate (PMA; 0.5 microM) and BHT alone (20 were studied. The different compounds had following potency stimulate ET secretion: PMA...
This report describes the metabolism of apolipoprotein B-containing lipoproteins in seven familial hypercholesterolemic (FH) homozygotes and compares results to values obtained from five healthy control subjects.The concentration, composition, large, triglyceride-rich very low density (VLDL,, Sf 60-400) were same FH groups, indicating that this component VLDL delipidation cascade was unaffected by absence receptors.In contrast, small VLDL, (Sf 20-60) enriched with cholesterol depleted...
To determine whether low low-density lipoprotein cholesterol (LDL-C) but not high-density (HDL-C) and triglyceride concentrations are associated with worse outcome in a large cohort of ischemic stroke patients treated IV thrombolysis.Observational multicenter post hoc analysis prospectively collected data thrombolysis registries. Because collinearity between total (TC) LDL-C, we used 2 different models TC (model 1) LDL-C 2).Of the 2,485 consecutive patients, 1,847 (74%) had detailed lipid...