A5003139544- Cholesterol and Lipid Metabolism
- Drug Transport and Resistance Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Digestive system and related health
- Atherosclerosis and Cardiovascular Diseases
- Antioxidant Activity and Oxidative Stress
- Adipose Tissue and Metabolism
- Retinoids in leukemia and cellular processes
- Pharmacological Effects and Toxicity Studies
- Caveolin-1 and cellular processes
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Lipid metabolism and disorders
- Nutrition, Genetics, and Disease
- Sphingolipid Metabolism and Signaling
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Inserm
2014-2025
Université de Lille
2015-2025
Centre Hospitalier Universitaire de Lille
2016-2025
Institut Pasteur de Lille
2014-2025
European Genomic Institute for Diabetes
2015-2024
Institut Pasteur
1996-2023
Université Lille Nord de France
2011-2012
Karolinska Institutet
2009
Institut de Chimie
1998-2009
University of Houston
2009
Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and nuclear FXR. BA sequestrants (BAS) complex bile in intestinal lumen decrease FXR activity. The BAS–BA also induces glucagon-like peptide-1 (GLP-1) production by L cells potentiates β-cell glucose-induced insulin secretion. Whether is expressed controls GLP-1 unknown. Here, we show that activation decreases proglucagon expression interfering with glucose-responsive factor Carbohydrate-Responsive Element...
Bile acids (BA) participate in the maintenance of metabolic homeostasis acting through different signaling pathways. The nuclear BA receptor farnesoid X (FXR) regulates pathways BA, lipid, glucose, and energy metabolism, which become dysregulated obesity. However, role FXR obesity associated complications, such as dyslipidemia insulin resistance, has not been directly assessed.Here, we evaluate consequences deficiency on body weight development, lipid resistance murine models genetic...
Objective To investigate the beneficial role of prebiotics on endothelial dysfunction, an early key marker cardiovascular diseases, in original mouse model linking steatosis and dysfunction. Design We examined contribution gut microbiota to vascular dysfunction observed apolipoprotein E knockout (Apoe −/− ) mice fed n-3 polyunsaturated fatty acid (PUFA)-depleted diet for 12 weeks with or without inulin-type fructans (ITFs) supplementation last 15 days. Mesenteric carotid arteries were...
Abstract —The serum amyloid A (SAA) family of proteins is encoded by multiple genes that display allelic variation and a high degree homology in mammals. Triggered inflammation after stimulation hepatocytes lymphokine-mediated processes, the concentrations SAA may increase during acute-phase reaction to levels 1000-fold greater than those found noninflammatory state. In addition its role as an reactant, (104 amino acids, 12 kDa) considered be precursor protein secondary reactive amyloidosis,...
Bile acids (BAs) are signaling molecules controlling energy homeostasis that can be both toxic and protective for the liver. BA alterations have been reported in obesity, insulin resistance (IR), nonalcoholic steatohepatitis (NASH). However, whether contribute to NASH independently of metabolic status is unclear. To assess associated with body mass index IR. Patients visiting obesity clinic Antwerp University Hospital (a tertiary referral facility) were recruited from 2006 2014. Obese...
We have recently shown that apo B-containing lipoproteins isolated by immunoaffinity chromatography bind to the LDL receptor with an affinity dependent on their E or CIII content. However, these lipoproteins--LpB:E, LpB:CIII, and LpB:CIII:E--isolated from whole plasma variable lipid apolipoprotein contents, it is difficult consider each parameter separately, particularly because increase in content always associated of other C apolipoproteins. Therefore, we used affinity-purified LpB free...
Liver X receptors (LXRs) are nuclear that regulate macrophage cholesterol efflux by inducing ATP-binding cassette transporter A1 (ABCA1) and ABCG1/ABCG4 gene expression. The Niemann-Pick C (NPC) proteins NPC1 NPC2 located in the late endosome, where they control trafficking to plasma membrane. mobilization of from intracellular pools membrane is a determinant governing its availability for extracellular acceptors. Here we investigated influence LXR activation on primary human macrophages....
Abstract The gut microbiota participates in the control of energy homeostasis partly through fermentation dietary fibers hence producing short-chain fatty acids (SCFAs), which turn promote secretion incretin Glucagon-Like Peptide-1 (GLP-1) by binding to SCFA receptors FFAR2 and FFAR3 on enteroendocrine L-cells. We have previously shown that activation nuclear Farnesoid X Receptor (FXR) decreases L-cell response glucose. Here, we investigated whether FXR also regulates SCFA-induced GLP-1...
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear activated by fatty acid derivatives and hypolipidemic drugs of the fibrate class. PPARalpha expressed in monocytes, macrophages, foam cells, suggesting role for this macrophage lipid homeostasis with consequences atherosclerosis development. Recently, it was shown that activation promotes cholesterol efflux from macrophages via induction ABCA1 pathway. In present study, influence activators on intracellular...
Bexarotene (Targretin) is a clinically used antitumoral agent which exerts its action through binding to and activation of the retinoid-X-receptor (RXR). The most frequent side-effect bexarotene administration an increase in plasma triglycerides, independent risk factor cardiovascular disease. molecular mechanism behind this hypertriglyceridemia remains poorly understood.Using wild-type LXR alpha/beta-deficient mice, we show here that induces activates hepatic LXR-target genes lipogenesis...
The role of the G-protein-coupled bile acid receptor TGR5 in various organs, tissues, and cell types, specifically intestinal endocrine L-cells brown adipose tissue, has made it a promising therapeutical target several diseases, especially type-2 diabetes metabolic syndrome. However, recent studies have shown deleterious on-target effects systemic agonists. To avoid these while stimulating glucagon-like peptide-1 (GLP-1) secreting enteroendocrine L-cells, we designed agonists with low...
Obesity is associated with metabolic dysfunction of white adipose tissue (WAT). Activated adipocytes secrete pro-inflammatory cytokines resulting in the recruitment macrophages, which contribute to WAT insulin resistance. The bile acid (BA)-activated nuclear Farnesoid X Receptor (FXR) controls systemic glucose and lipid metabolism. Here, we studied role FXR function.
This study attempted to determine if low density lipoproteins (LDL) induce the production of endothelins (ET) by human macrophages. Non-protected LDL from macrophage induced oxidation (n-LDL), copper-oxidized (Ox-LDL), acetylated-LDL (Ac-LDL), butylated hydroxytoluene-LDL (BHT-LDL), BHT-Ac-LDL, polyinosinic acid (PiA, 1.5 micrograms/ml), phorbol myristate acetate (PMA; 0.5 microM) and BHT alone (20 were studied. The different compounds had following potency stimulate ET secretion: PMA...
The activity of the antitumoral agent bexarotene (Targretin, Bexarotene) depends on its binding to nuclear retinoid-X receptor (RXR) and subsequent transcriptional regulation target genes. Through RXR activation, may modulate numerous metabolic pathways involved in atherosclerosis. Here, we investigated effect atherosclerosis progression a dyslipidemic murine model, human apolipoprotein E2 knockin mouse, that develops essentially macrophage-laden lesions.Atherosclerotic lesions together with...
Peroxisome proliferator-activated receptor (PPAR)-α is a transcription factor controlling lipid metabolism in liver, heart, muscle, and macrophages. receptor-α activation increases plasma HDL cholesterol exerts hypotriglyceridaemic actions via the liver. However, intestine expresses PPAR-α, produces chylomicrons, exposed to diet-derived PPAR-α ligands. Therefore, we examined effects of on intestinal lipoprotein metabolism.The impact was evaluated term HDL-related gene expression mice, ex...