A5059015964- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Diabetes Treatment and Management
- Pancreatitis Pathology and Treatment
- Drug Transport and Resistance Mechanisms
Laboratoire CarMeN
2023-2024
Inserm
2020-2023
Université Claude Bernard Lyon 1
2023
Hospices Civils de Lyon
2023
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023
Institut Pasteur de Lille
2020-2021
Université de Lille
2020-2021
Centre Hospitalier Universitaire de Lille
2020-2021
Abstract The gut microbiota participates in the control of energy homeostasis partly through fermentation dietary fibers hence producing short-chain fatty acids (SCFAs), which turn promote secretion incretin Glucagon-Like Peptide-1 (GLP-1) by binding to SCFA receptors FFAR2 and FFAR3 on enteroendocrine L-cells. We have previously shown that activation nuclear Farnesoid X Receptor (FXR) decreases L-cell response glucose. Here, we investigated whether FXR also regulates SCFA-induced GLP-1...
Progressive decline in pancreatic beta-cell function is central to the pathogenesis of type 2 diabetes (T2D). Here, we explore relationship between beta cell and its nutritional environment, asking how an excess energy substrate leads altered production subsequent insulin secretion. Alterations intracellular metabolic homeostasis are key markers islets with T2D, but changes cellular metabolite exchanges their environment remain unknown. We answered this question using nuclear magnetic...