A5114376077- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Colorectal Cancer Treatments and Studies
- Galectins and Cancer Biology
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Nuclear Receptors and Signaling
- Macrophage Migration Inhibitory Factor
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Acute Lymphoblastic Leukemia research
- Protein Degradation and Inhibitors
- PI3K/AKT/mTOR signaling in cancer
- Cancer Research and Treatments
- RNA Research and Splicing
- CNS Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Parkinson's Disease Mechanisms and Treatments
- Genomics and Phylogenetic Studies
- Gene expression and cancer classification
- Chronic Myeloid Leukemia Treatments
- Genomic variations and chromosomal abnormalities
- Cancer-related molecular mechanisms research
Centre National de la Recherche Scientifique
2010-2025
Unité de Glycobiologie Structurale et Fonctionnelle
2015-2025
Institut Pasteur de Lille
2010-2025
Inserm
2009-2025
Université de Lille
2016-2025
Centre Hospitalier Universitaire de Lille
2016-2025
Institut de Biologie de Lille
2010-2023
Institut de Génomique Fonctionnelle
2010-2023
Université Paris Cité
2018
Assistance Publique – Hôpitaux de Paris
2018
Abstract Purpose: Next-generation sequencing (NGS) has detailed the genomic characterization of diffuse large B-cell lymphoma (DLBCL) by identifying recurrent somatic mutations. We set out to design a clinically feasible NGS panel focusing on genes whose mutations hold potential therapeutic impact. Furthermore, for first time, we evaluated prognostic value these in prospective clinical trials. Experimental Design: A Lymphopanel was designed identify 34 genes, selected according literature...
Abstract Purpose: Whole-genome sequencing has revealed MYD88 L265P and CXCR4 mutations (CXCR4mut) as the most prevalent somatic in Waldenström macroglobulinemia. mutation proved to be of critical importance macroglobulinemia, part due its role a mechanism resistance several agents. We have therefore sought unravel different aspects Experimental Design: scanned two coding exons macroglobulinemia using deep next-generation Sanger 98 patients with correlated SNP array landscape mutational...
Primary mediastinal B‐cell lymphoma (PMBL) is an entity of distinct from the other molecular subtypes diffuse large (DLBCL). We investigated prevalence, specificity, and clinical relevance mutations XPO1 , which encodes a member karyopherin‐β nuclear transporters, in cohort PMBL. PMBL cases defined histologically or by gene expression profiling (GEP) were sequenced mutational status was correlated to genetic characteristics. The also assessed DLBCL, Hodgkin (HL) gray‐zone (MGZL).The...
Purpose:MYD88 mutations, notably the recurrent gain-of-function L265P variant, are a distinguishing feature of activated B-cell like (ABC) diffuse large lymphoma (DLBCL), leading to constitutive NFκB pathway activation. The aim this study was examine distinct genomic profiles MYD88-mutant DLBCL, according presence or other non-L265P MYD88 variants.Experimental Design: A cohort 361 DLBCL cases (94 mutant and 267 wild-type) submitted next-generation sequencing (NGS) focusing on 34 genes...
// Houria Debarri 1, 2, * , Delphine Lebon 3, Christophe Roumier 4 Meyling Cheok 4, 5 Alice Marceau-Renaut Olivier Nibourel Sandrine Geffroy Nathalie Helevaut 2 Philippe Rousselot 6 Bérengère Gruson 3 Claude Gardin 7 Marie-Lorraine Chretien 8 Shéhérazade Sebda Martin Figeac Céline Berthon Bruno Quesnel Nicolas Boissel 9 Sylvie Castaigne Hervé Dombret Aline Renneville Preudhomme 1 Hematology Department, Lille University Hospital, Lille, France...
Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk developing Alzheimer's disease (AD) and mitigates both amyloid Tau lesions in transgenic mouse models disease. While short-term treatment with A2AR antagonists have been shown to alleviate cognitive deficits amyloidogenesis, impact chronic long-term on development burden, associated neuroinflammation memory has never assessed. In present study, we evaluated effect 6-month APPsw/PS1dE9 mice...
Abstract The molecular mechanisms underlying caudal-to-rostral progression of Lewy body pathology in Parkinson’s disease remain poorly understood. Here, we identified transcriptomic signatures across brain regions involved Braak stages non-neurological adults from the Allen Human Brain Atlas. Among genes that are indicative regional vulnerability, found known genetic risk factors for disease: SCARB2 , ELOVL7, SH3GL2 SNCA BAP1 and ZNF184 . Results were confirmed two datasets subjects, while...
Abstract Cellular senescence is implicated in a great number of diseases including cancer. Although alterations mitochondrial metabolism were reported as drivers, the underlying mechanisms remain elusive. We report mechanism altering function and OXPHOS stress-induced senescent fibroblasts. demonstrate that TRPC3 protein, acting controller Ca 2+ load via negative regulation IP 3 receptor-mediated release, down regulated regardless type inducer. This remodelling promotes...
Abstract Metastasis and drug resistance are major problems in cancer chemotherapy. The purpose of this work was to analyze the molecular mechanisms underlying invasive potential drug-resistant colon carcinoma cells. Cellular models included parental HT-29 cell line its derivatives selected after chronic treatment with either 5-fluorouracil, methotrexate, doxorubicin, or oxaliplatin. Drug-resistant cells were compared noninvasive using cDNA microarray, quantitative reverse transcription-PCR,...
The prevention of fertilization through self-pollination (or pollination by a close relative) in the Brassicaceae plant family is determined genotype at self-incompatibility locus (S locus). many alleles this exhibit dominance hierarchy that determines which two allelic specificities heterozygous expressed phenotypic level. Here, we uncover evolution how least 17 small RNA (sRNA)-producing loci and their multiple target sites collectively control among within gene controlling pollen S-locus...
V(D)J recombinations in lymphocytes are essential for immunological diversity. They also useful markers of pathologies. In leukemia, they used to quantify the minimal residual disease during patient follow-up. However, full breadth lymphocyte diversity is not fully understood. We propose new algorithms that process high-throughput sequencing (HTS) data extract unnamed junctions and gather them into clones quantification. This analysis based on a seed heuristic fast scalable because first...
// Jean-Emmanuel Bibault 1,3,* , Martin Figeac 2,3,* Nathalie Hélevaut 1 Céline Rodriguez Sabine Quief 2,4 Shéhérazade Sebda Aline Renneville 1,3,5 Olivier Nibourel Philippe Rousselot 6 Bérengère Gruson 7 Hervé Dombret 8 Sylvie Castaigne and Claude Preudhomme 1,3 Laboratory of Hematology, CHRU de Lille, France 2 Functional Structural Genomic Platform, 3 University Lille Nord France, 4 Institut Pour la Recherche sur le Cancer 5 Inserm, UMR-S1172, Department Hôpital Versailles, Le Chesnay,...
Gut dysbiosis due to the adverse effects of antibiotics affects outcomes lung infection. Previous murine models relied on significant depletion both gut and microbiota, rendering analysis immune gut-lung cross-talk difficult. Here, we study antibiotic-induced without immunity consequences acute P. aeruginosa infection.C57BL6 mice received 7 days oral vancomycin-colistin, followed by normal regimen or fecal microbial transplant Fms-related tyrosine kinase 3 ligand (Flt3-Ligand) over 2 days,...