A5007220163- Ion Channels and Receptors
- Ion channel regulation and function
- Neurobiology and Insect Physiology Research
- Cardiac electrophysiology and arrhythmias
- Angiogenesis and VEGF in Cancer
- Calcium signaling and nucleotide metabolism
- Nicotinic Acetylcholine Receptors Study
- Connexins and lens biology
- Neuroscience and Neuropharmacology Research
- Endoplasmic Reticulum Stress and Disease
- Biochemical Analysis and Sensing Techniques
- Pancreatic function and diabetes
- Phytochemicals and Antioxidant Activities
- Neuropeptides and Animal Physiology
- Bioactive Compounds and Antitumor Agents
- Toxin Mechanisms and Immunotoxins
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Heat shock proteins research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Mass Spectrometry Techniques and Applications
- Ion Transport and Channel Regulation
- Protein Kinase Regulation and GTPase Signaling
- Telomeres, Telomerase, and Senescence
- Neuroscience and Neural Engineering
Université de Lille
2016-2025
Inserm
2016-2025
La Ligue Contre le Cancer
2012-2025
Laboratoire de Physiologie Cellulaire
2011-2024
Laboratoire d'Excellence Canaux Ioniques d'Intérêt Thérapeutique
2012-2024
Onco Lille
2015-2024
Bogomoletz Institute of Physiology
2003-2018
Université des Sciences, de Technologie et de Médecine
2013
Weatherford College
2013
Centre National de la Recherche Scientifique
1994-2011
Abstract Cellular senescence is induced by stresses and results in a stable proliferation arrest accompanied pro-inflammatory secretome. Senescent cells accumulate during aging, promoting various age-related pathologies limiting lifespan. The endoplasmic reticulum (ER) inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) calcium-release channel calcium fluxes from the ER to mitochondria are drivers of human cells. Here we show that Itpr2 knockout (KO) mice display improved aging such as...
Although human pannexins (PanX) are homologous to gap junction molecules, their physiological function in vertebrates remains poorly understood. Our results demonstrate that overexpression of PanX1 the formation Ca2+-permeable channels between adjacent cells, thus, allowing direct intercellular Ca2+ diffusion and facilitating wave propagation. More intriguingly, our strongly suggest may also form endoplasmic reticulum (ER). These contribute ER leak thereby affect load. Because leakage most...
Castration resistance in prostate cancer (PCa) constitutes an advanced, aggressive disease with poor prognosis, associated uncontrolled cell proliferation, to apoptosis, and enhanced invasive potential. The molecular mechanisms involved the transition of PCa castration are obscure. Here, we report that nonselective cationic channel transient receptor potential vanilloid 2 (TRPV2) is a distinctive feature castration-resistant PCa. TRPV2 transcript levels were higher patients metastatic (stage...
Store-operated calcium entry (SOCE) is the main Ca2+ influx pathway involved in controlling proliferation of human hepatoma cell lines Huh-7 and HepG2. However, molecular nature channels this process remains unknown. HepG2 cells express transient receptor potential canonical 1 (TRPC1) TRPC6, as well STIM1 Orai1, these 4 are most likely candidates to account for SOCE cells. We generated stable TRPC6-overexpressing or TRPC6-knockdown clones, which we investigated correlations between presence...
Abstract One major clinical problem with prostate cancer is the cells' ability to survive and proliferate upon androgen withdrawal. Because Ca2+ central growth control, understanding mechanisms of homeostasis involved in cell proliferation imperative for new therapeutic strategies. Here, we show that agonist-mediated stimulation α1-adrenergic receptors (α1-AR) promotes primary human epithelial (hPCE) cells by inducing store-independent entry subsequent activation nuclear factor activated T...
The molecular nature of calcium (Ca2+)-dependent mechanisms and the ion channels having a major role in apoptosis cancer cells remain subject debate. Here, we show that recently identified Orai1 protein represents component endogenous store-operated Ca2+ entry (SOCE) human prostate (PCa) cells, constitutes principal source influx used by cell to trigger apoptosis. downregulation Orai1, consequently SOCE, protects from diverse apoptosis-inducing pathways, such as those induced thapsigargin...
In recent years, the transient receptor potential melastatin member 8 (TRPM8) channel has emerged as a promising prognostic marker and putative therapeutic target in prostate cancer (PCa). However, mechanisms of prostate-specific regulation functional evolution TRPM8 during PCa progression remain unclear. Here we show, for first time to our knowledge, that only secretory mature differentiated human primary epithelial (PrPE) luminal cells expressed plasma membrane ((PM)TRPM8) channels....
The endoplasmic reticulum (ER) is involved in many cellular functions, including protein folding and Ca2+ homeostasis. ability of cells to respond the ER stress critical for cell survival, disruption such regulation can lead apoptosis. accompanied by alterations homeostasis, store depletion itself induce Despite that, leak channels activated response remain poorly characterized. Here we demonstrate that during occurs via translocon, complex translation. Numerous inducers stimulate be...
Significance Transient receptor potential vanilloid subfamily member 6 (TRPV6) is a highly selective Ca 2+ channel that exercises its normal physiological function via absorption in the intestine and kidney. Intriguingly, we show TRPV6 may switch from well-known constitutive activity to store operated due remodeling mechanism involving STIM1/Orai1/TRPC1-induced activation of translocation plasma membrane /Annexin I/S100A11 pathway. Moreover, demonstrate discovered used by prostate cancer...