A5063885350- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Vascular Tumors and Angiosarcomas
- CNS Lymphoma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Acute Myeloid Leukemia Research
- Breast Implant and Reconstruction
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Cardiac tumors and thrombi
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
- Breast Cancer Treatment Studies
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Chromatin Remodeling and Cancer
- Alcohol Consumption and Health Effects
- Neuroscience of respiration and sleep
- Cutaneous lymphoproliferative disorders research
- Liver Disease and Transplantation
Hôpitaux Universitaires Henri-Mondor
2017-2025
Inserm
2012-2025
Assistance Publique – Hôpitaux de Paris
2012-2025
Institut Mondor de Recherche Biomédicale
2016-2025
Université Paris-Est Créteil
2012-2024
Centre Hospitalier Universitaire Henri-Mondor
2001-2022
Hôpital Albert-Chenevier
2017-2022
Hudson Institute
2019
Merck Institute for Science Education
2019
John Wiley & Sons (United States)
2019
Abstract Hepatosplenic T-cell lymphoma (HSTL) is a rare and lethal lymphoma; the genetic drivers of this disease are unknown. Through whole-exome sequencing 68 HSTLs, we define recurrently mutated driver genes copy-number alterations in disease. Chromatin-modifying genes, including SETD2, INO80, ARID1B, were commonly HSTL, affecting 62% cases. HSTLs manifest frequent mutations STAT5B (31%), STAT3 (9%), PIK3CD for which there currently exist potential targeted therapies. In addition, noted...
ABSTRACT Liver lipid peroxidation, nonheme iron, antioxidants, and protein oxidation were investigated in experimental alcohol–induced liver disease the rat. Wistar male rats intragastrically continuously infused for 4 weeks with a high–fat diet plus an ethanol or isocaloric amount of dextrose, maintaining high blood alcohol level (200–300 mg%). This model induced fatty liver, spotty necrosis, focal inflammation. pathology was associated enhanced peroxidation decrease major antioxidant...
Significance Mutations in isocitrate dehydrogenase ( IDH ) 1 and IDH2 contribute to malignant progression by producing the oncometabolite 2HG. In myeloid disorders, mutations at three positions these genes are commonly observed, but angioimmunoblastic T-cell lymphoma (AITL), restricted arginine (R) 172. The complex microenvironment of AITL, where T cells comprise a minority tumor, has made it difficult evaluate role this mutation. Here, we provide clinical data showing that mutant expression...
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare aggressive most reported in Asia. We performed comprehensive clinical, pathological and genomic study of 71 European MEITL patients (36 males, 35 females, median age 67 years). The majority presented with gastrointestinal involvement had emergency surgery, 40% stage IV disease. tumors were morphologically classified into two groups: typical (58%) atypical (i.e., non-monomorphic or necrosis, angiotropism starry-sky...
Vascular endothelial growth factor (VEGF) is a potent cell and permeability highly expressed in rodent alveolar epithelium after injury repair. To investigate VEGF synthesis human lung epithelial cells, we examined expression by cultured cells under basal conditions cytokine treatment or oxidative stress. Basal was detected transformed lines (A549 1HAEo-) primary bronchial with RT-PCR, Western blot, immunocytochemistry. Among the cytokines tested, only transforming factor-beta1 increased...
Abstract Angioimmunoblastic T-cell lymphoma (AITL) is a frequent in the elderly population that has poor prognosis when treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) therapy. Lenalidomide, which been safely combined CHOP to treat B-cell lymphoma, shown efficacy as single agent AITL treatment. We performed multicentric phase 2 trial combining 25 mg lenalidomide daily for 14 days per cycle 8 cycles of CHOP21 previously untreated patients aged 60 80 years. The...
We previously reported that ethanol elicits an increased protein oxidation in the liver of rats receiving chronic by continuous intragastric infusion (Tsukamoto–French method). This accumulation oxidized proteins could result from a decrease cytosolic proteolysis, related specifically to alkaline protease and its major components, proteasomes. Because several studies suggest intracellular proteolysis depends on severity oxidative stress, we investigated proteolytic activity under two...
Abstract Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic kinase (ALK)-positive, and ALK-negative, primary cutaneous breast implant-associated ALCL. Prognosis of some ALCL subgroups is still unsatisfactory, already in second line effective treatment options are lacking. To identify genes defining state dependencies, we here characterize super-enhancer regions by genome-wide H3K27ac ChIP-seq. In addition to known key regulators,...
Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations their functional roles in ENKTCL could help improve patient stratification treatments. In this study, we performed comprehensive analysis 178 cases to delineate landscape mutations, copy number (CNA), structural variations, identifying 34 driver genes including six previously unappreciated ones, namely, HLA-B,...
Peripheral T-cell lymphoma comprises a heterogeneous group of mature non-Hodgkin lymphomas. Their diagnosis is challenging, with up to 30% cases remaining unclassifiable and referred as "not otherwise specified". We developed reverse transcriptase-multiplex ligation-dependent probe amplification gene expression profiling assay differentiate the main entities study heterogeneity specified" category. The test evaluates 20 genes, including 17 markers relevant immunology biopathology, one...
ALK-negative anaplastic large cell lymphoma (ALCL) comprises subgroups harboring rearrangements of DUSP22 (DUSP22- R) or TP63 (TP63-R). Two studies reported 90% and 40% 5-year overall survival (OS) rates in 21 12 DUSP22-R/TP63- not rearranged (NR) patients, respectively, making the prognostic impact DUSP22-R unclear. Here, 104 newly diagnosed ALCL patients (including 37 from first-line clinical trials) LYSA TENOMIC database were analyzed by break-apart fluorescence situ hybridization assays...
Lymphomas of T-follicular helper origin (T-follicular helper–cell lymphoma [TFHL]) are often accompanied by an expansion B-immunoblasts, occasionally with Hodgkin/Reed-Sternberg-like (HRS-like) cells, making the differential diagnosis classic Hodgkin (CHL) difficult. We compared morphologic, immunophenotypic, and molecular features 15 TFHL 12 CHL samples discussed 4 challenging cases uncertain diagnosis. Compared CHL, disclosed more frequent sparing subcortical sinuses, high-endothelium...
Cyr61 is a secreted, cysteine-rich heparin-binding protein that associated with extracellular matrix and cell surface, has been demonstrated to be proangiogenic in vitro. In the present study we evaluated angiogenic effect of human an adenoviral context rabbit ischemic hindlimb model. For this purpose, three randomized groups New Zealand White rabbits received intramuscular injections 5 x 10(8) infectious units adenovirus carrying either gene (Ad-Cyr61), vascular endothelial growth factor...
Abstract Objective Angioimmunoblastic T‐cell lymphoma (AITL) is frequently associated with autoimmune cytopenia (AIC). Whether such patients have a particular phenotype and require management unclear. Method from the multicentric database of Lymphoma Study Association presenting AIC during disease course were included matched to AITL without (1/5 ratio). Results At diagnosis, (n = 28) had more spleen bone marrow involvement (54% vs 19% 71% 34%, P < 0.001), Epstein‐Barr virus replication...