A5064697535- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- T-cell and Retrovirus Studies
- Fibroblast Growth Factor Research
- Colorectal Cancer Treatments and Studies
- Viral-associated cancers and disorders
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Inflammatory Bowel Disease
- Protein Tyrosine Phosphatases
- Inflammasome and immune disorders
- Radiomics and Machine Learning in Medical Imaging
- Phagocytosis and Immune Regulation
- Cancer, Hypoxia, and Metabolism
- CNS Lymphoma Diagnosis and Treatment
- AI in cancer detection
- Melanoma and MAPK Pathways
- Microscopic Colitis
- Chronic Lymphocytic Leukemia Research
Nantes Université
2015-2024
Inserm
2011-2024
Centre de Recherche en Nutrition Humaine Rhône-Alpes
2024
Université de Caen Normandie
2024
Centre Hospitalier Universitaire de Caen Normandie
2024
Centre National de la Recherche Scientifique
2014-2023
Oxfam
2023
Liechtenstein Institute
2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Abstract Chimeric antigen receptor (CAR) T-cell therapy has emerged as an option for relapsed/refractory aggressive B-cell lymphomas that have failed 2 lines of therapy. Failures usually occur early after infusion. The purpose our study was to identify factors may predict failure, particularly progression (EP), within the first month Characteristics 116 patients were analyzed at time decision (TD) use commercial CAR (axicabtagene ciloleucel, n = 49; tisagenlecleucel 67) and treatment (TT),...
Purpose To prospectively assess the clinical impact of expert review lymphoma diagnosis in France. Materials and Methods From January 2010 to December 2013, 42,145 samples from patients with newly diagnosed or suspected lymphomas were reviewed, according 2008 WHO classification, real time by experts through Lymphopath Network. Changes between referral classified as major minor their potential on patient care. Results The reviewed comprised 36,920 mature lymphomas, 321 precursor lymphoid...
Abstract Enteropathy-associated T-cell lymphoma (EATL), a rare and aggressive intestinal malignancy of intraepithelial T lymphocytes, comprises two disease variants (EATL-I EATL-II) differing in clinical characteristics pathological features. Here we report findings derived from whole-exome sequencing 15 EATL-II tumour-normal tissue pairs. The tumour suppressor gene SETD2 encoding non-redundant H3K36-specific trimethyltransferase is altered 14/15 cases (93%), mainly by loss-of-function...
IL-10 is an immunomodulatory cytokine that plays obligate role in preventing spontaneous enterocolitis mice. However, little known about function the human intestinal mucosa. We showed here was constitutively expressed and secreted by normal colonic mucosa, including epithelial cells. Depletion of mucosal explants induced both downregulation IL-10–inducible, immunosuppressive gene BCL3 upregulation IFN-γ, TNF-α, IL-17. Interestingly, TGF-β blockade also strongly IFN-γ production. In...
Gut bacterium Faecalibacterium prausnitzii activates a newly identified set of human IL-10-producing Treg cells (CD4CD8αα lymphocytes), revealing mechanism by which commensal microbes contribute to host immunity.
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare aggressive most reported in Asia. We performed comprehensive clinical, pathological and genomic study of 71 European MEITL patients (36 males, 35 females, median age 67 years). The majority presented with gastrointestinal involvement had emergency surgery, 40% stage IV disease. tumors were morphologically classified into two groups: typical (58%) atypical (i.e., non-monomorphic or necrosis, angiotropism starry-sky...
Abstract The host immune response plays a major role in colorectal carcinoma (CRC) progression. A mechanism of tumor escape might involve expression the human leucocyte antigen (HLA)‐E/β2m on cells. inhibitory effect HLA‐E/β2m CD8+ cytotoxic T lymphocytes and natural killer (NK) cells is mediated by main HLA‐E receptor CD94/NKG2A. As pathophysiological relevance this CRC remains unknown, prompted us to examine, situ , series 80 ( i ) β2m coexpression cells, ii density CD8+, cytotoxic, CD244+...
Aberrant activity of the receptor tyrosine kinases MET, AXL, and FGFR1/2/3 has been associated with tumor progression in a wide variety human malignancies, notably instances primary or acquired resistance to existing emerging anticancer therapies. This study describes preclinical characterization S49076, novel, potent inhibitor AXL/MER, FGFR1/2/3. S49076 potently blocked cellular phosphorylation FGFRs inhibited downstream signaling vitro vivo. In cell models, proliferation MET-...
Gray-zone lymphoma (GZL) with features intermediate between classic Hodgkin (cHL) and large B-cell (LBCL) was introduced as a provisional entity into the World Health Organization classification in 2008. However, diagnostic criteria are imprecise, reliable identification of GZL cases remains challenging. Here, we describe histopathologic 139 from retrospective Lymphoma Study Association (LYSA) study goal to improve accuracy. Inclusion were based on literature review an expert consensus...
Abstract Angioimmunoblastic T-cell lymphoma (AITL) is a frequent in the elderly population that has poor prognosis when treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) therapy. Lenalidomide, which been safely combined CHOP to treat B-cell lymphoma, shown efficacy as single agent AITL treatment. We performed multicentric phase 2 trial combining 25 mg lenalidomide daily for 14 days per cycle 8 cycles of CHOP21 previously untreated patients aged 60 80 years. The...
Recently, the inhibitory CD94/NKG2A receptor has joined group of immune checkpoints (ICs) and its expression been documented in NK cells CD8+ T lymphocytes several cancers some infectious diseases. In colorectal cancer (CRC), we previously reported that NKG2A+ tumor-infiltrating (TILs) are predominantly αβ CD94 overexpression and/or ligand HLA-E were associated with a poor prognosis. This study aimed to thoroughly characterize TIL subpopulation document impact NKG2A on anti-tumor responses...
Colon cancer stem cells (CSCs), considered responsible for tumor initiation and relapse, are constantly exposed to regulatory cues emanating from neighboring present in the microenvironment. Among these enteric glial (EGCs) that potent regulators of epithelium functions a healthy intestine. However, whether EGCs impact CSC-driven tumorigenesis remains unknown.Impact human EGC primary cultures or non-transformed line on CSCs isolated colon adenocarcinomas cell lines with different p53, MMR...
Microsatellite instability (MSI) due to mismatch repair (MMR) deficiency has been reported occur at variable frequencies in inflammatory bowel disease-associated intestinal neoplasias (IBD-Ns). We investigated a large series of IBD-N for associations between MSI and several biologic clinical parameters related tumors, patients, their treatment.A total 277 IBD-Ns 205 patients were screened MSI. Biologic variables with high levels DNA microsatellite (MSI-H) collected compared those associated...