A5012774144- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Liver Diseases and Immunity
- Hepatitis C virus research
- Inflammatory Bowel Disease
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Celiac Disease Research and Management
- Neurofibromatosis and Schwannoma Cases
- Gastrointestinal disorders and treatments
- Inflammasome and immune disorders
- Neuroendocrine Tumor Research Advances
- Microscopic Colitis
- Hepatitis B Virus Studies
- Viral Infections and Immunology Research
- Hematopoietic Stem Cell Transplantation
- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
Centre Hospitalier Universitaire de Nantes
2016-2025
Nantes Université
2013-2024
Inserm
2001-2024
Centre d'Investigation Clinique de Nantes
2018-2024
Institut de Transplantation Urologie en Nephrologie
2020-2021
Center for Research in Transplantation and Translational Immunology
2020-2021
Hôtel-Dieu de Paris
2015-2020
Digestive Health Research Institute
2019
Laboratoire de Thermique et Energie de Nantes
2012-2015
Zimmer Biomet (France)
2010-2015
Abstract During analysis of CD8 T cells derived from ascites a colon cancer patient, we isolated Vγ9Vδ2 cell clone showing strong reactivity against autologous tumor lines. This killed large fraction allogeneic carcinoma and melanoma lines, but did not affect normal line, fibroblasts, or melanocytes. Tumor recognition was TCR NKG2D dependent induced TNF-α IFN-γ secretion by the clone; accordingly, targets expressed several ligands, such as MHC class I chain-related gene A UL16-binding...
In 27 patients who had bled from esophagogastric varices, large-sized and/or actively bleeding gastric varices were endoscopically obturated with the tissue adhesive butyl cyanoacrylate. Active was stopped in six patients. Rebleeding occurred 10 patients; four patients, rebleeding due to ruptured early and successfully treated by reinjection of varices; one patient, attributed ulceration on an injected varix. Eight died: two (from esophageal or undetermined source), sepsis liver failure at...
It remains unknown what causes inflammatory bowel disease (IBD), including signaling networks perpetuating chronic gastrointestinal inflammation in Crohn's (CD) and ulcerative colitis (UC), humans. According to an analysis of up 500 patients with IBD 100 controls, we report that key transcripts the IL-7 receptor (IL-7R) pathway are accumulated inflamed colon tissues severe CD UC not responding either immunosuppressive/corticosteroid, anti-TNF, or anti-α4β7 therapies. High expression both...
<h3>OBJECTIVE</h3> When to suspect a paraneoplastic disorder is puzzling problem that has not recently been studied in large series of patients referred for peripheral neuropathy. <h3>METHODS</h3> From 422 consecutive with neuropathy, 26 were analysed who concomitantly had carcinoma but no tumorous infiltration, drug toxicity, or cachexia. Their clinical, pathological, and electrophysiological data according the presence anti-onconeural antibodies, latency between presentation cancer...
Intraportal lymphoid nodules have been observed in liver biopsy specimens from patients with autoimmune disease and chronic active hepatitis C. They are characterized by a nodular lymphocyte aggregate germinal center. The purpose of this situ immunophenotyping study was to determine immunohistochemically the phenotype immunocompetent cells around intraportal For comparison, we also examined disease. Liver 13 unselected CAH C antibodies 7 seen during same period were studied. Sections...
Background —There are still discrepancies in the association of enterovirus and myocardial disease, partially due to lack data on detection virus antigens tissues. It is desirable localize enteroviral so as establish a link between two study mechanisms persistence. Methods Results —Nineteen fixed explanted or postmortem samples were obtained from patients with myocarditis dilated cardiomyopathy (DCM). Control collected 11 subjects who had died accidentally noncardiovascular disease. Viral...
Abstract The ADAM17 metalloproteinase (a disintegrin and metalloprotease 17) controls epidermal growth factor receptor (EGFR) activation through regulated shedding of EGFR ligands. With the advent new therapeutic options targeting signalling in colon carcinoma, it was decided to determine status relation clinico‐pathological parameters status. To this end, a series 39 carcinomas were analysed. Immunohistochemistry immunofluorescence used localize ADAM17, EGFR, activated forms EGFR. form...
Irinotecan (CPT-11) is approved in metastatic colorectal cancer treatment and can cause severe toxicity. The main purpose of our study was to assess the role different polymorphisms on occurrence hematologic toxicities disease-free survival high-risk stage III colon patients receiving 5-fluorouracil (5FU) CPT-11 adjuvant chemotherapy regimen a prospective randomized trial.Four hundred were phase trial comparing LV5FU2 + CPT-11. DNA from 184 extracted genotyped detect nucleotide polymorphism:...
Abstract The host immune response plays a major role in colorectal carcinoma (CRC) progression. A mechanism of tumor escape might involve expression the human leucocyte antigen (HLA)‐E/β2m on cells. inhibitory effect HLA‐E/β2m CD8+ cytotoxic T lymphocytes and natural killer (NK) cells is mediated by main HLA‐E receptor CD94/NKG2A. As pathophysiological relevance this CRC remains unknown, prompted us to examine, situ , series 80 ( i ) β2m coexpression cells, ii density CD8+, cytotoxic, CD244+...
T cell exclusion causes resistance to cancer immunotherapies via immune checkpoint blockade (ICB). Myeloid cells contribute by expressing signal regulatory protein-α (SIRPα), an inhibitory membrane receptor that interacts with ubiquitous CD47 control macrophage phagocytosis in the tumor microenvironment. Although CD47/SIRPα-targeting drugs have been assessed preclinical models, therapeutic benefit of selectively blocking SIRPα, and not SIRPγ/CD47, humans remains unknown. We report a potent...
Agonistic proresolutive monoclonal antibody reverses chronic inflammation.
Long-term survival after pancreatectomy for pancreatic duct adenocarcinoma has been rarely reported. Factors influencing are still debated. The aim of the study is to report a French multicentric series long-term survivors adenocarcinoma.Data patients who survived >5 years (February 1983-January 2000) were analyzed. All operative specimens reviewed. Patients with intraductal-papillary-mucinous-neoplasia, cystadenocarcinoma, acinous-adenocarcinoma, neuroendocrine, or mixed tumors...
Autoimmune hepatitis (AIH) is a rare disease characterized by an immune attack of the liver. This study consists comprehensive analysis alterations related to AIH at diagnosis, and during remission phase under treatment. A total 37 major lymphocyte populations were analyzed from peripheral blood new‐onset patients (AIHn; n = 14), with controlled (n 11), healthy subjects 14). Liver biopsy analyses performed complete phenotypic analysis. Four significantly altered in AIHn diagnosis compared...
Microsatellite instability (MSI) due to mismatch repair (MMR) deficiency has been reported occur at variable frequencies in inflammatory bowel disease-associated intestinal neoplasias (IBD-Ns). We investigated a large series of IBD-N for associations between MSI and several biologic clinical parameters related tumors, patients, their treatment.A total 277 IBD-Ns 205 patients were screened MSI. Biologic variables with high levels DNA microsatellite (MSI-H) collected compared those associated...