A5059194761- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Dermatology and Skin Diseases
- Cell Adhesion Molecules Research
- Sepsis Diagnosis and Treatment
- Neonatal and Maternal Infections
- Psoriasis: Treatment and Pathogenesis
- Phagocytosis and Immune Regulation
- Inflammatory Bowel Disease
- Urticaria and Related Conditions
- Complementary and Alternative Medicine Studies
- Advanced Biosensing Techniques and Applications
- Systemic Lupus Erythematosus Research
- Immune cells in cancer
- Eosinophilic Esophagitis
- Nanoplatforms for cancer theranostics
- Allergic Rhinitis and Sensitization
- Vasculitis and related conditions
- Biosensors and Analytical Detection
- Whipple's Disease and Interleukins
OSE Immunotherapeutics (France)
2022-2023
Inserm
2015-2022
Nantes Université
2016-2022
Center for Research in Transplantation and Translational Immunology
2018-2021
Institut de Transplantation Urologie en Nephrologie
2016-2020
IMT Atlantique
2019
Centre d'Investigation Clinique de Nantes
2018
Infectious Disease Models and Innovative Therapies
2014-2017
Institut de Recherche Vaccinale
2014-2017
Université Paris-Sud
2014-2017
It remains unknown what causes inflammatory bowel disease (IBD), including signaling networks perpetuating chronic gastrointestinal inflammation in Crohn's (CD) and ulcerative colitis (UC), humans. According to an analysis of up 500 patients with IBD 100 controls, we report that key transcripts the IL-7 receptor (IL-7R) pathway are accumulated inflamed colon tissues severe CD UC not responding either immunosuppressive/corticosteroid, anti-TNF, or anti-α4β7 therapies. High expression both...
Abstract FR104 is a monovalent pegylated Fab′ Ab, antagonist of CD28, under development for treatment transplant rejection and autoimmune diseases. In contrast to CD80/86 antagonists (CTLA4-Ig), selectively blunts CD28 costimulation while sparing CTLA-4 PD-L1 coinhibitory signals. the present work, has been evaluated in first-in-human study evaluate safety, pharmacokinetics, pharmacodynamics, potency i.v. administrations healthy subjects. Sixty-four subjects were randomly assigned four...
Dendritic cells are major APCs that can efficiently prime immune responses. However, the roles of skin-resident Langerhans (LCs) in eliciting responses have not been fully understood. In this study, we demonstrate for first time, to our knowledge, LCs cynomolgus macaque skin capable inducing antiviral-specific vivo. Targeting HIV-Gag or influenza hemagglutinin Ags using recombinant fusion proteins anti-Langerin Ab and resulted induction viral Ag-specific We further demonstrated such elicited...
Immune profiling by flow cytometry is not always possible on fresh blood samples due to time and/or transport constraints. Furthermore, the cryopreservation of peripheral mononuclear cells (PBMC) requires on-site specialized lab facilities, thus severely restricting extent which immune monitoring can be applied multicenter clinical studies. These major limitations addressed through development simplified whole freezing methods.In this report, we describe an optimized easy protocol for rapid...
The development of new immunization strategies requires a better understanding early molecular and cellular events occurring at the site injection. skin is particularly rich in immune cells represents an attractive for vaccine administration. Here, we specifically targeted antigens to epidermal Langerhans (LCs) using fusion protein composed HIV monoclonal antibody targeting Langerin. We developed fluorescence imaging approach visualize, vivo, vaccine-targeted cells. Studies were performed...
Objective: Dendritic cells (DCs) are critical effectors of innate and adaptive immunity playing crucial roles in autoimmune responses. We previously showed that blood DC numbers were reduced ANCA-associated vasculitis (AAV). Here, we assessed toll-like receptor (TLR) responsiveness DCs from patients with granulomatosis polyangiitis (GPA) or microscopic (MPA). Methods: Blood samples healthy controls (HC), GPA MPA patients, without treatment, during acute phase (AP) remission (RP) analyzed....
Crohn’s disease (CD), a form of inflammatory bowel (IBD), is characterized by impaired epithelial barrier functions and dysregulated mucosal immune responses. IL-22 binding protein (IL-22BP) soluble inhibitor regulating bioactivity, cytokine proposed to play protective roles during CD. We others have shown that IL-22BP produced in IBD inflamed tissues, hence suggesting role In this work, we extended the characterization production distribution CD tissues applying enzyme-linked immunosorbent...
Purpose . We developed a new approach to visualize skin Langerhans cells by in vivo fluorescence imaging nonhuman primates. Procedures Macaques were intradermally injected with monoclonal, fluorescently labeled antibody against HLA-DR molecule and imaged for up 5 days fibered confocal microscopy (FCFM). Results The network of was visualized microscopy. Quantification revealed no changes cell density time. Ex experiments confirmed that fluorescent specifically targeted the epidermis....
Abstract Background: Signal Regulatory Protein α [SIRPα] is an inhibitory membrane receptor expressed by myeloid cells (macrophages and myeloid-derived suppressor cells, MDSCs) specifically binds to CD47. BI765063 a selective anti-SIRPα monoclonal antibody acting as checkpoint inhibitor of SIRPα/CD47 axis, promoting anti-tumor immunity through increase dendritic antigen presentation, enabling MDSC differentiation, potentiating macrophage phagocytic/inflammatory properties reinstating cell...
ABSTRACT Background Immune profiling by flow cytometry is not always possible on fresh blood samples due to time and/or transport constraints. Besides, the cryopreservation of peripheral mononuclear cells (PBMC) requires on-site specialized lab facilities, thus severely restricting extent which immune monitoring can be applied multicenter clinical studies. These major limitations addressed through development simplified whole freezing methods. Methods In this report, we describe an optimized...
Abstract Background: BI 765063 (OSE-172) is a humanised IgG4 monoclonal antibody which binds selectively to the V1 allele of Signal Regulatory Protein α [SIRPα] blocking SIRPα/CD47 “don't eat me” pathway. Preclinical studies showed that SIRPα blockage led macrophage and T-cell recruitment into tumor xenografts, induced upregulation chemokines, cytokines adaptive immune function genes in human explants (Gauttier et al., 2020). The goal biomarker analyses was characterize impact on peripheral...
Abstract Crohn’s disease (CD), a form of inflammatory bowel (IBD), is characterized by impaired epithelial barrier functions and dysregulated mucosal immune responses. IL-22 binding protein (IL-22BP) soluble inhibitor regulating bioactivity, cytokine proposed to play protective roles during CD. We others have shown that IL-22BP produced in IBD inflamed tissues, hence suggesting role In this work, we extended the characterization production distribution CD tissues applying enzyme-linked...