A5073322732- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Autoimmune and Inflammatory Disorders
- Peroxisome Proliferator-Activated Receptors
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Immunodeficiency and Autoimmune Disorders
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Diverticular Disease and Complications
- Eosinophilic Disorders and Syndromes
- Digestive system and related health
- Immune Response and Inflammation
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Probiotics and Fermented Foods
- Pharmacological Receptor Mechanisms and Effects
- Asthma and respiratory diseases
- Inflammatory mediators and NSAID effects
- Gastric Cancer Management and Outcomes
- Pharmacological Effects of Natural Compounds
- Celiac Disease Research and Management
- Drug Transport and Resistance Mechanisms
Centre Hospitalier Universitaire de Lille
2016-2025
Inserm
2015-2025
Université de Lille
2016-2025
Hôpital Claude Huriez
2015-2025
Lille Inflammation Research International Center
2015-2024
Institute for Translational Research in Inflammation
2021-2024
Lille’s Cardiology Hospital
2006-2024
Université Lille Nord de France
2010-2023
Paris Biotech Santé
2022
Centre Hospitalier Universitaire de Rennes
2019
Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin-12 and interleukin-23, was evaluated as an intravenous induction therapy in two populations with moderately severely active Crohn's disease. Ustekinumab also subcutaneous maintenance therapy. We randomly assigned patients receive single dose ustekinumab (either 130 mg or approximately 6 per kilogram body weight) placebo trials. The UNITI-1 trial included 741 who met criteria for primary secondary nonresponse tumor necrosis...
The ileal mucosa of Crohn disease (CD) patients is abnormally colonized by adherent-invasive E. coli (AIEC) that are able to adhere and invade intestinal epithelial cells. Here, we show CD-associated AIEC strains the brush border primary enterocytes isolated from CD but not controls without inflammatory bowel disease. adhesion dependent on type 1 pili expression bacterial surface carcinoembryonic antigen–related cell molecule 6 (CEACAM6) apical We report also CEACAM6 acts as a receptor for...
5-aminosalicylic acid (5-ASA) is an antiinflammatory drug widely used in the treatment of inflammatory bowel diseases. It known to inhibit production cytokines and mediators, but mechanism underlying intestinal effects 5-ASA remains unknown. Based on common activities peroxisome proliferator–activated receptor-γ (PPAR-γ) ligands 5-ASA, we hypothesized that this nuclear receptor mediates therapeutic action. To test possibility, colitis was induced heterozygous PPAR-γ+/− mice their wild-type...
The peroxisome proliferator–activated receptor γ (PPARγ) is highly expressed in the colon mucosa and its activation has been reported to protect against colitis. We studied involvement of PPARγ heterodimeric partner, retinoid X (RXR) intestinal inflammatory responses. PPARγ1/− RXRα1/− mice both displayed a significantly enhanced susceptibility 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis compared with their wild-type littermates. A role for RXR/PPARγ heterodimer protection...
Background & AimsMost patients with Crohn's disease (CD) eventually require an intestinal resection. However, CD frequently recurs after We performed a randomized trial to compare the ability of infliximab vs placebo prevent recurrence.MethodsWe evaluated efficacy in preventing postoperative recurrence 297 at 104 sites worldwide from November 2010 through May 2012. All study had undergone ileocolonic resection within 45 days before randomization. Patients were randomly assigned (1:1) groups...
<h3>Objective</h3> Mesenteric fat hyperplasia is a hallmark of Crohn9s disease (CD), and C reactive protein (CRP) correlated with activity. The authors investigated whether mesenteric adipocytes may be source CRP in CD inflammatory bacterial triggers stimulate its production by adipocytes. <h3>Design</h3> expression the subcutaneous fats patients correlation between plasma concentrations messenger RNA (mRNA) levels were assessed. impact challenges on synthesis was tested using an adipocyte...
Early pathological manifestations of Crohn's disease (CD) include vascular disruption, T cell infiltration nerve plexi, neuronal degeneration, and induction helper 1 cytokine responses. This study demonstrates that disruption the enteric glial network in CD patients represents another early feature may be modeled after CD8(+) cell-mediated autoimmune targeting glia double transgenic mice. Mice expressing a viral neoself antigen astrocytes were crossed with specific receptor mice, resulting...
Interleukin 5 (IL-5) is the main factor that promotes terminal differentiation of eosinophil progenitors (as indicated by colony formation assays), and enhances effector capacity mature eosinophils. IL-5 produced T lymphocytes, CD4-/CD8- mast cells recently, messenger (m)RNA this cytokine has been identified in eosinophils from patients with coeliac disease, asthma, or eosinophilic heart diseases. In study, mRNA immunoreactive protein were detected tissue blood cystitis hypereosinophilic...
Bacterial agents have been implicated in the early recurrence of Crohn's disease after ileocolectomy. The aim our study was to identify and quantify bacteria associated with ileal mucosa patients controls correlate specific recurrence.The predominant bacterial microflora ileum were enumerated identified, aerobically anaerobically, biopsies obtained at time surgery or by endoscopy from 61 10 ileocolectomy controls. specimens comprised 13 taken resection specimens, seven ileostomy, 41...
Celiac disease is a gluten-induced enteropathy characterized by the presence of gliadin-specific CD4(+) T cells in lamina propria and prominent intraepithelial T-cell infiltration unknown mechanism. The aim this study was to characterize subset(s) lymphocytes (IELs) expanding during active celiac provide insights into mechanisms involved their expansion.Flow-cytometric analysis isolated IELs and/or immunohistochemical staining frozen sections were performed 51 patients 50 controls with panel...
Interleukin 5 (IL-5), the major factor involved in eosinophil differentiation, is produced by T cells or mast cells. In present study, we found that eosinophils infiltrating mucosa of four patients with active coeliac disease also express IL-5 mRNA. No positive signal was obtained normal duodenum tissues and cell infiltrate from submitted to gluten restriction. The identification labeled mucosal as relied on their typical morphology. Moreover, highly purified blood three out eosinophilia...
MICA are distant homologs of MHC class I molecules expressed in the normal intestinal epithelium. They ligands NKG2D activating receptor on most γδ T cells, CD8+ αβ and natural killer cells therefore play a critical role innate immune responses. We investigated cell-surface expression infection epithelial cell lines by enteric bacteria show here that can be markedly increased diffusely adherent Escherichia coli diarrheagenic group. This effect is mediated specific interaction between...