A5005517169- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Advanced Breast Cancer Therapies
- Monoclonal and Polyclonal Antibodies Research
- Histone Deacetylase Inhibitors Research
- CAR-T cell therapy research
- Phagocytosis and Immune Regulation
- Myasthenia Gravis and Thymoma
- Acute Lymphoblastic Leukemia research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Mechanisms and Therapy
- Peripheral Neuropathies and Disorders
- Single-cell and spatial transcriptomics
- Platelet Disorders and Treatments
- Acute Myeloid Leukemia Research
- Multiple Sclerosis Research Studies
- Mast cells and histamine
- Melanoma and MAPK Pathways
- Cell death mechanisms and regulation
Université Côte d'Azur
2007-2025
Hôpital l'Archet
2011-2024
Inserm
2001-2023
Institut National de Recherche en Santé Publique
2007-2023
Centre Hospitalier Universitaire de Nice
2009-2021
Institut de Biologie Valrose
2021
Centre Méditerranéen de Médecine Moléculaire
2021
Hôpital Pasteur
2016-2017
Centre Hospitalier de Cannes
2015
Medical University of Vienna
2006
An impaired inhibitory function of circulating CD4+CD25+ regulatory T (Treg) cells was reported to play a key role in alopecia areata (AA). We report the first use our knowledge low-dose interleukin 2 for treating severe AA by promoting recruitment Treg cells.We conducted prospective open pilot study 5 patients with resistant previous systemic treatments. Subcutaneous (1.5 million IU/d) administered during days, followed three 5-day courses 3 IU/d at weeks 3, 6, and 9. The primary outcome...
CD47 on the surface of T cells was shown in vitro to mediate either cell activation or, presence high amounts thrombospondin (TSP), apoptosis. We report here that CD47-deficient mice, as well TSP-1 or TSP-2-deficient sustain oxazolone-induced inflammation for more than four days, whereas wild-type mice reduce within 48 h. observe prolonged CD47-, TSP-1-, is accompanied by a local deficiency Finally, we show upon normal increase expression proapoptotic Bcl-2 family member BNIP3...
Different rituximab protocols are used to treat membranous nephropathy. We compared two in patients with nephropathy.Twenty-eight participants from the NICE cohort received infusions of 1-g at 2-week intervals, whereas 27 Prospective Randomized Multicentric Open Label Study Evaluate Rituximab Treatment for Membranous Nephropathy (GEMRITUX) 375 mg/m2 1-week interval. measured serum levels and remission month 6 before any treatment modification analyzed factors associated relapses.Remissions...
Abstract Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive leukemia for which we developed nationwide network to collect data from new cases diagnosed in France. In retrospective, observational study of 86 patients (2000-2013), described clinical biological focusing on morphologies immunophenotype. We found expression markers associated with origin (HLA-DRhigh, CD303+, CD304+, cTCL1+) plus CD4 CD56 frequent isolated the myeloid, B-, T-lymphoid lineages, whereas...
GPI-anchored surface proteins mediate many important functions, including transport, signal transduction, adhesion, and protection against complement. They cluster into glycolipid-based membrane domains caveolae, plasmalemmal vesicles involved in the transcytosis endocytosis of these proteins. However, lymphocytes, neither characteristic flask shaped caveolae nor caveolin, a transmembrane protein typical have been observed. Here, we show that CD59 molecule on Jurkat T cells is internalized...
The SARS-CoV-2 infection has spread rapidly around the world causing millions of deaths. Several treatments can reduce mortality and hospitalization. However, their efficacy depends on choice molecule precise timing its administration to ensure viral clearance avoid a deleterious inflammatory response. Here, we investigated IFN-γ, assessed by functional immunoassay, as predictive biomarker for risk hospitalization at an early stage or within one month prior infection. Individuals with IFN-γ...
Abstract The clinical course of patients with chronic lymphocytic leukemia (CLL) is heterogeneous some requiring early therapy whereas others will not be treated for years. evaluation an individual CLL patient's prognosis remains a problematic issue. presence or absence somatic mutations in the IgVH genes currently gold‐standard prognostic factor, but this technique labor intensive and costly. Genomic studies uncovered that 70 kDa zeta‐associated protein (ZAP‐70) expression was associated...
Abstract BACKGROUND. To the authors' knowledge, genetic abnormalities in early‐stage chronic lymphocytic leukemia (CLL) have not been examined fully. Single nucleotide polymorphism (SNP) genomic array (SNP‐chip) is a new tool that can detect copy number changes and uniparental disomy (UPD) over entire genome with very high resolution. METHODS. The authors performed SNP‐chip analysis on 56 samples from patients early‐stage, untreated CLL. validate data, fluorescence situ hybridization (FISH)...
Objective: To assess changes over time in neuropsychological test results (NPr) and risk factors among a regularly followed HIV-infected patient population. Methods: Prospective cohort of patients randomly selected to undergo follow-up. Test score was adjusted for age, sex education. Patients were divided into five groups: normal tests, deficit (one impaired cognitive domain), asymptomatic neurocognitive disorders (ANIs), mild (MNDs) HIV-associated dementia (HAD). Demographic background...
Blastic plasmacytoid dendritic cell neoplasm is an aggressive malignancy derived from cells. There currently no accepted standard of care for treating this neoplasm, and therapeutic strategies have never been prospectively evaluated. Since blastic cells express high levels interleukin-3 receptor α chain (IL3-Rα or CD123), antitumor effects the receptor-targeted drug SL-401 against were evaluated in vitro vivo. The cytotoxicity was assessed patient-derived lines (CAL-1 GEN2.2) primary...
Abstract IAP is a glycoprotein functionally and physically associated with some integrins, i.e., the leukocyte response integrin beta3 chain on placenta, platelets, polymorphonuclear cells. may act as transducer element in activation mediated via these integrins. Since present at high density peripheral T lymphocytes we have investigated its involvement cell activation. We tested three mAbs against IAP, namely B6H12, BRIC126, 2D3, which recognize two distinct epitopes. cross-linking B6H12 or...
Abstract Loss of tumor-suppressive pathways that control cellular senescence is a crucial step in malignant transformation. Spleen tyrosine kinase (Syk) cytoplasmic has been recently implicated tumor suppression melanoma, deadly skin cancer derived from pigment-producing melanocytes. However, the mechanism by which Syk suppresses melanoma growth remains unclear. Here, we report reexpression cells induces p53-dependent expression cyclin-dependent (cdk) inhibitor p21 and program. We first...
Abstract The glycosylphosphatidylinositol (GPI)‐anchored CD59 protein (human protectin) protects cells against complement‐induced lysis, binds to CD2 and also transduces activation signals within T cells. We have further examined the biochemical transduced by addressed its role in regard CD3‐mediated signaling cascade. show here that cross‐linking induces a time‐dependent of p56 lck p70 zap (ZAP‐70) CD3‐positive Jurkat cells, leading stimulation cell receptor ζ/ZAP‐70 cascade interleukin‐2...
CD99/E2 is an integral transmembrane protein which forms, together with Xga, a distinct family whose genes are located in the pseudoautosomal region. The number of T cells that firmly bound to vascular endothelial under physiological shear stress increased 2–14-fold upon CD99 stimulation, and became much more resistant detachment forces spread. cell arrest occurred within 1 min was dependent on α4β1-VCAM-1 pathway. In contrast, αLβ2-ICAM-1 pathway remained unactivated. This observed lines...