A5043145257- Immune Cell Function and Interaction
- T-cell and Retrovirus Studies
- T-cell and B-cell Immunology
- Animal Disease Management and Epidemiology
- CAR-T cell therapy research
- HIV Research and Treatment
- Axon Guidance and Neuronal Signaling
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Neuroinflammation and Neurodegeneration Mechanisms
- Vector-Borne Animal Diseases
- Chemokine receptors and signaling
- Ion channel regulation and function
- Autoimmune Neurological Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Cytokine Signaling Pathways and Interactions
- Zebrafish Biomedical Research Applications
- Angiogenesis and VEGF in Cancer
- Viral Infectious Diseases and Gene Expression in Insects
- Neurogenesis and neuroplasticity mechanisms
- Chronic Lymphocytic Leukemia Research
- PI3K/AKT/mTOR signaling in cancer
- Multiple Myeloma Research and Treatments
- Cellular transport and secretion
- Immunodeficiency and Autoimmune Disorders
Institut de Génétique Moléculaire de Montpellier
1998-2023
Inserm
1992-2019
Centre National de la Recherche Scientifique
2000-2019
Institut NeuroMyoGène
2016-2019
Université Claude Bernard Lyon 1
2009-2019
Hospices Civils de Lyon
2018
Centre de Recherche en Neurosciences de Lyon
2011
Institut Pasteur
1993-2004
National Institutes of Health
2002
National Human Genome Research Institute
2002
<h3>Importance</h3> Autoantibodies against contactin-associated protein-like 2 (CASPR2) are observed in several neurological syndromes, including neuromyotonia (NMT), Morvan syndrome (MoS), and limbic encephalitis. <h3>Objective</h3> To characterize the clinical biological presentations of patients with anti-CASPR2 antibodies cerebrospinal fluid (CSF). <h3>Design, Setting, Participants</h3> We conducted a retrospective cohort analysis 18 who had their CSF between March 2009 November 2015 at...
Multiple myeloma (MM) is a B-cell neoplasia that associated with an increased level of bone resorption. One important mediator remodelling, insulin-like growth factor (IGF-I), has been shown to stimulate the proliferation human cells. However, mechanisms action IGF-I in these cells have not determined. Using interleukin (IL)-6-dependent cell lines, we show be as potent survival and IL-6. We demonstrated functions independently IL-6 transducer gp130 two cytokines additive effects. Moreover,...
Severe combined immune deficiency (SCID) is a heterogeneous disorder characterized by profound defects in cellular and humoral immunity. We report here an infant with clinical laboratory features of SCID selective CD4 lymphopenia lack CD28 expression on CD8(+) T cells. cells from this patient showed poor blastogenic responses to various mitogens IL-2. Other cell antigen receptor- induced responses, including upregulation CD69, were similarly inhibited. However, more proximal receptor...
Differences in the immunological reactivity of umbilical cord (UC) and adult peripheral blood (APB) T cells are poorly understood. Here, we show that IL-7, a cytokine involved lymphoid homeostasis, has distinct regulatory effects on APB UC lymphocytes. Neither naive nor memory CD4 + proliferated response to whereas lymphocytes underwent multiple divisions. Nevertheless, both IL-7-treated progressed into G 1b phase cell cycle, albeit at higher levels latter subset. The lymphocyte population...
In the central nervous system, collapsin response mediator protein 2 (CRMP2) is a transducer that supports semaphorin-induced guidance of axons toward their cognate target. However, we previously showed CRMP2 also expressed in immune cells and plays crucial role T lymphocyte migration. Here further investigated molecular mechanisms underlying function chemokine-directed T-cell motility. Examining Jurkat T-cells treated with chemokine CXCL12, found 1) CXCL12 induces dynamic re-localization to...
ABSTRACT Caspr2 and TAG-1 (also known as CNTNAP2 CNTN2, respectively) are cell adhesion molecules (CAMs) associated with the voltage-gated potassium channels Kv1.1 Kv1.2 KCNA1 KCNA2, at regions controlling axonal excitability, namely, axon initial segment (AIS) juxtaparanodes of myelinated axons. The distribution Kv1 requires axo-glial contacts mediated by TAG-1. In present study, we found that strongly colocalizes AIS cultured hippocampal neurons, whereas is uniformly expressed along...
CD19 is a B cell-specific receptor that regulates the threshold of cell (BCR)-mediated proliferation. A CD47xCD19 bispecific antibody (biAb) was generated to target and deplete cells via multiple antibody-mediated mechanisms. Interestingly, biAb, constructed binding arm CD47 arm, inhibited BCR-mediated B-cell proliferation with an effect even more potent than monoclonal (mAb). The inhibitory biAb not attributable because monovalent or bivalent anti-CD47 mAb had no on Fluorescence resonance...
Objective: To investigate the role of Fas–Fas ligand (FasL) interaction in HIV-1-induced apoptosis primary CD4+ T lymphocytes. Design: Activated lymphocytes are main target HIV, and T-cell activation leads to expression Fas–FasL enhances HIV-mediated apoptosis. Phytohemagglutinin-activated cells were infected with HIV; process cell death was examined, whether dying dead productively cells. The modulation Fas FasL its HIV-induced also investigated. Methods: number viable determined by trypan...
IL-22 is an IL-10 homologue that binds to and signals via the class II cytokine receptor (R) heterodimer IL-22RA1/CFR2-4 (IL-10R2), latter chain being part of IL-10R complex. Here, we report that, despite its structural similarity with IL-10, as well use common IL-10R2 chain, IL-22, in contrast unable induce Ig production by activated human B cells. Whereas culture anti-CD40 mAb-stimulated splenic or tonsillar cells presence rIL-10 resulted IgG, IgG1, IgG3 IgA, rIL-22, at concentrations...
Boyer V, Delibrias C, Noraz N, Fischer E, Kazatchkine MD, Desgranges C. Complement Receptor Type 2 Mediates Infection of the Human CD4‐Negative Raji B‐Cell Line with Opsonized HIV. Scand J Immunol 1992;36:879‐83 Opsonization HTLV‐RF and HTLV‐IIIB strains HIV‐1 normal human HIV seronegative serum under conditions that allow complement activation resulted in productive infection cells B lymphoblastoid cell line. Under same experimental conditions, no was observed unopsonized virus....
Recent studies have highlighted the key role of immune protein CD3ζ in maturation neuronal circuits CNS. Yet, upstream signals that might recruit and activate neurons are still unknown. In this study, we show functions early development identify ephrinA1-dependent EphA4 receptor activation as an regulator CD3ζ. When newly born spherical, before neurite extension, found a transient aggregation at cell periphery matching initiation site future neurite. This accumulation correlated with...
To investigate whether HTLV-I infection, HIV-1 or infection of HTLV-I-infected cells affect the expression cellular surface molecules, an T cell line derived from H9 was established (H36). uninfected infected with were then HIV-1. We have compared density different markers on these three lines. These consist cell-specific antigens (CD2, CD3, CD4, and CD8), activated (CD25 CD71), major histocompatibility complex (MHC) (class I II), adhesion molecules (LFA-1 ICAM-1). The experiments reported...
Multiple myeloma (MM) is a B‐cell neoplasia that associated with an increased level of bone resorption. One important mediator remodelling, insulin‐like growth factor (IGF‐I), has been shown to stimulate the proliferation human cells. However, mechanisms action IGF‐I in these cells have not determined. Using interleukin (IL)‐6‐dependent cell lines, we show be as potent survival and IL‐6. We demonstrated functions independently IL‐6 transducer gp130 two cytokines additive effects. Moreover,...