A5021986215- Cell Adhesion Molecules Research
- Melanoma and MAPK Pathways
- Cytokine Signaling Pathways and Interactions
- Cellular Mechanics and Interactions
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Ubiquitin and proteasome pathways
- Eosinophilic Disorders and Syndromes
- Cutaneous lymphoproliferative disorders research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Advanced Breast Cancer Therapies
- Signaling Pathways in Disease
- Histone Deacetylase Inhibitors Research
- Hippo pathway signaling and YAP/TAZ
- Cell death mechanisms and regulation
- CAR-T cell therapy research
- Cancer Mechanisms and Therapy
- NF-κB Signaling Pathways
- FOXO transcription factor regulation
- Protein Kinase Regulation and GTPase Signaling
- HER2/EGFR in Cancer Research
- Mast cells and histamine
Université Côte d'Azur
2015-2025
Inserm
2015-2025
Institut de Recherche sur le Cancer et le Vieillissement de Nice
2021-2025
Centre Méditerranéen de Médecine Moléculaire
2009-2024
La Ligue Contre le Cancer
1992-2023
Hôpital Lariboisière
2023
Centre Hospitalier Universitaire de Nice
2009-2023
Institut National de Recherche en Santé Publique
2009-2023
Dermscan Group (France)
2022
University Hospital Cologne
2020
Targeting cancer cell metabolism is a new promising strategy to fight cancer. Metformin, widely used antidiabetic agent, exerts antitumoral and antiproliferative action. In this study, the addition of metformin 2-deoxyglucose (2DG) inhibited mitochondrial respiration glycolysis in prostate cells leading severe depletion ATP. The combination two drugs was much more harmful for than treatment with or 2DG alone, 96% inhibition viability LNCaP cells. contrast, moderate effect on observed normal...
Background Large language models (LLMs) have raised both interest and concern in the academic community. They offer potential for automating literature search synthesis systematic reviews but raise concerns regarding their reliability, as tendency to generate unsupported (hallucinated) content persist. Objective The aim of study is assess performance LLMs such ChatGPT Bard (subsequently rebranded Gemini) produce references context scientific writing. Methods replicating results...
During progression of melanoma, malignant melanocytes can be reprogrammed into mesenchymal-like cells through a process similar to epithelial-mesenchymal transition (EMT), which is associated with downregulation the junctional protein E-cadherin and acquisition migratory phenotype. Recent evidence supports role for SLUG, transcriptional repressor E-cadherin, as melanocyte lineage transcription factor that predisposes melanoma metastasis. However, signals responsible SLUG expression in are...
Disruption of the endothelial barrier by tumour-derived secreted factors is a critical step in cancer cell extravasation and metastasis. Here, comparative proteomic analysis melanoma secretomes, we identify matricellular protein SPARC as novel vascular permeability factor. deficiency abrogates tumour-initiated lung capillaries prevents extravasation, whereas overexpression enhances leakiness, SPARC-induced paracellular dependent on VCAM1 receptor p38 MAPK signalling. Blocking impedes...
GPI-anchored surface proteins mediate many important functions, including transport, signal transduction, adhesion, and protection against complement. They cluster into glycolipid-based membrane domains caveolae, plasmalemmal vesicles involved in the transcytosis endocytosis of these proteins. However, lymphocytes, neither characteristic flask shaped caveolae nor caveolin, a transmembrane protein typical have been observed. Here, we show that CD59 molecule on Jurkat T cells is internalized...
Aberrant extracellular matrix (ECM) deposition and stiffening is a physical hallmark of several solid cancers associated with therapy failure. BRAF-mutant melanomas treated BRAF MEK inhibitors almost invariably develop resistance that frequently transcriptional reprogramming de-differentiated cell state. Melanoma cells secrete their own ECM proteins, an event promoted by oncogenic inhibition. Yet, the contribution cancer cell-derived tumor mechanics to drug adaptation remains poorly...
Cross-linking of the T cell antigen receptor (TCR)-CD3 complex induces rapid tyrosine phosphorylation and activation Src (Lck Fyn) Syk (Syk Zap-70) family protein kinases (PTKs) which, in turn, phosphorylate multiple intracellular substrates. Cbl is a prominent PTK substrate suggesting pivotal role for it early signal transduction events. However, regulation function cells by upstream PTKs remains poorly understood. In present study, we used genetic biochemical approaches to demonstrate that...
We have previously described E2 as a 32-kDa transmembrane glycoprotein displaying an isomorphism, two epitopes (defined by mAbs O662 and L129) are widely distributed on T cells whereas restricted to cell subsets D44 12E7). E2, the MIC-2 gene product, is involved in adhesion because anti-E2 against pan block spontaneous rosettes. Pan also able induce exposure of phosphatidylserine at thymocyte surface but not mature lymphocytes, event most likely linked phenomena. now show here that (0662...
The T cell surface molecule CD2 forms, with its counter-receptor CD58 (LFA-3), a powerful adhesion/activation pathway. There is some evidence that might bind more than single ligand. Chinese hamster ovary cells (CHO) expressing human CD59 after cDNA transfection (CD59+CHO) form rosettes cells; these are inhibited in dose-dependent fashion by the monoclonal antibody (mAb) H19 and mAb O275 known to block natural rosettes, but not CD2R D66, poor rosette blocker. CD2+CHO transfectants...
Abstract Imatinib is used to treat chronic myelogenous leukemia (CML), but resistance develops in all phases of this disease. The purpose the present study was identify mode newly derived imatinib-resistant (IM-R) and PD166326-resistant (PD-R) CML cells. IM-R PD-R clones exhibited an increase viability a decrease caspase activation response various doses imatinib PD166326, respectively, as compared with parental K562 Resistance involved neither mutations BCR-ABL nor increased BCR-ABL, MDR1...
Abstract SPARC is an extracellular matrix protein that exerts pleiotropic effects on organization, growth factor availability, cell adhesion, differentiation, and immunity in cancer. Chronic myelogenous leukemia (CML) cells resistant to the BCR-ABL inhibitor imatinib (IM-R cells) were found overexpress mRNA. In this study, we show triggers accumulation a variety of tyrosine kinase (TKI)–resistant CML lines. silencing IM-R restored sensitivity, whereas enforced expression imatinib-sensitive...
Abstract Advanced cutaneous melanoma is one of the most challenging cancers to treat because its high plasticity, metastatic potential, and resistance treatment. New targeted therapies immunotherapies have shown remarkable clinical efficacy. However, such treatments are limited a subset patients relapses often occur, warranting validation novel therapies. Posttranslational modification proteins by ubiquitin coordinates essential cellular functions, including ubiquitin-proteasome system (UPS)...