A5002961219- Inflammatory Bowel Disease
- Microscopic Colitis
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- Mycobacterium research and diagnosis
- Biosimilars and Bioanalytical Methods
- Autoimmune and Inflammatory Disorders
- Gut microbiota and health
- Liver Disease and Transplantation
- Gastric Cancer Management and Outcomes
- Clostridium difficile and Clostridium perfringens research
- Esophageal and GI Pathology
- Diagnosis and treatment of tuberculosis
- Gastrointestinal motility and disorders
- Liver Diseases and Immunity
- Pregnancy and Medication Impact
- Gastroesophageal reflux and treatments
- Colorectal Cancer Surgical Treatments
- Monoclonal and Polyclonal Antibodies Research
Bellvitge University Hospital
2016-2025
Universitat de Barcelona
2012-2025
Institut d'Investigació Biomédica de Bellvitge
2015-2024
Merrion Fertility Clinic
2024
Ajuntament de L’Hospitalet
2021-2024
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2017-2020
Hull York Medical School
2020
Bassetlaw Hospital
2020
University of Medicine 2 Yangon
2020
University of Copenhagen
2020
Spontaneous bacterial empyema (SBEM) is an infection of a preexisting hydrothorax in cirrhotic patients and has seldom been reported. To determine its incidence primary characteristics, all with pleural effusion underwent thoracentesis at our hospital either on admission or when was suspected. Pleural fluid (PF) study included biochemical analysis, polymorphonuclear (PMN) leukocyte count, culture by two methods: conventional modified (inoculation 10 mL PF into blood bottle the bedside). SBEM...
Fecal calprotectin (FC), as determined by the enzyme-linked immunoassay (ELISA) test, has been proposed a promising biomarker of endoscopic activity in Crohn's disease (CD). However data on its accuracy predicting remission according to location and postoperative recurrence (POR) is scarce. Our objective was evaluate ability FC new quantitative point-of-care test (FC-QPOCT) predict POR CD patients.FC simultaneously an (FC-ELISA) FC-QPOCT patients undergoing colonoscopy. Clinical assessed...
DNA methylation biomarkers for noninvasive diagnosis of colorectal cancer (CRC) and precursor lesions have been extensively studied. Different panels reported attempting to improve current protocols in clinical practice, although no definite established. In the present study, we examined patient biopsies starting from a comprehensive analysis differences between paired normal tumor samples known cancer-related genes aiming select best performing candidates informative CRC stool samples. Five...
Fecal calprotectin (FC) determined by the enzyme-linked immunosorbent assay (ELISA) test has been proposed as a promising biomarker of endoscopic activity in ulcerative colitis (UC). However, data on its accuracy predicting is scarce. Besides, FC quantitative-point-of-care (FC-QPOCT) that provides rapid and individual results could optimize use clinical practice. The aims our study were to evaluate ability predict according Mayo score patients with UC when FC-QPOCT compare it ELISA...
The aims of this study were to assess the risk relapse after discontinuation anti-tumor necrosis factor (anti-TNF) drugs in patients with inflammatory bowel disease (IBD), identify factors associated relapse, and evaluate overcome retreatment same anti-TNF those who relapsed.This was a retrospective, observational, multicenter study. IBD had been treated anti-TNFs whom these discontinued clinical remission achieved included.A total 1,055 included. incidence rate 19% 17% per patient-year...
The development programm UNIFI has shown promising results of ustekinumab in ulcerative colitis [UC] treatment which should be confirmed clinical practice. We aimed to evaluate the durability, effectiveness, and safety UC real life.Patients included prospectively maintained ENEIDA registry, who received at least one intravenous dose due active [Partial Mayo Score [PMS]>2], were included. Clinical activity effectiveness defined based on PMS. Short-term response was assessed Week 16.A total 95...
Transcatheter arterial chemoembolization (TACE) has been used as a palliative treatment for patients with unresectable hepatocellular carcinoma (HCC), but its prognostic usefulness not previously clarified.The authors reviewed all treated at their institution TACE HCC in order to analyze factors and determine which might benefit from this treatment. One hundred forty-three were retrospectively studied. Pretreatment, treatment, follow-up variables possible significance analyzed. A stepwise...
RJ 2.2.5 is a human B cell line that has lost the capacity to express MHC class II genes. The II-positive phenotype restored in somatic hybrids between and mouse spleen cells. By karyotype molecular studies of an informative family we have now shown reexpression gene products, as well maintenance phenotype, correlates with presence chromosome 16. Thus, existence on this newly found locus, designated by us aIr-1, determines trans-acting activator function for expression, established. Possible...
Psoriasis induced by anti-tumor necrosis factor-α (TNF) therapy has been described as a paradoxical side effect.To determine the incidence, clinical characteristics, and management of psoriasis anti-TNF in large nationwide cohort inflammatory bowel disease patients.Patients with were identified from Spanish prospectively maintained Estudio Nacional en Enfermedad Inflamatoria Intestinal sobre Determinantes genéticos y Ambientales registry Grupo Español de Trabajo Croh Colitis Ulcerosa....
Postoperative recurrence of Crohn's disease [POR-CD] is almost certain if no prophylaxis administered. Evidence for optimal treatment lacking. Our aim was to compare the efficacy adalimumab [ADA] and azathioprine [AZA] in this setting. We performed a phase 3, 52-week, multicentre, randomised, superiority study [APPRECIA], which patients with ileocolonic resection were randomised either ADA 160-80-40 mg subcutaneously [SC] or AZA 2.5 mg/kg/day, both associated metronidazole. The primary...
Background Histological remission has been proposed as a new treatment goal in patients with ulcerative colitis (UC) although no universal definition for microscopic activity exists. Aim We evaluated the accuracy of histological to predict clinical relapse UC both and endoscopic remission. Methods Asymptomatic (Mayo sub‐score 0 or 1) undergoing surveillance colonoscopy two referral hospitals were prospectively recruited. All colonic biopsies analyzed according Geboes’ score (GS) presence...
Prediction models for colorectal cancer (CRC) detection in symptomatic patients, based on easily obtainable variables such as fecal haemoglobin concentration (f-Hb), age and sex, may simplify CRC diagnosis. We developed, then externally validated, a multivariable prediction model, the FAST Score, with data from five diagnostic test accuracy studies that evaluated quantitative immunochemical tests patients referred colonoscopy. The of Score derivation validation cohorts was compared...
Ulcerative colitis [UC] is a chronic inflammatory disease of the colon. Colonoscopy remains gold standard for evaluating activity, as clinical symptoms are not sufficiently accurate. The aim this study to identify new accurate non-invasive biomarkers based on whole-blood transcriptomics that can predict mucosal lesions and response treatment in UC patients.Whole-blood samples were collected total 152 patients at endoscopy. Blood RNA from 25 individuals 20 controls was analysed using...
There is controversy as to whether the risk of relevant infection in IBD related immunosuppressants or disease itself. The aims this study were evaluate: [1] life-long prevalence and types infections patients with immunosuppressive treatment, [2] relationship both patient comorbidity mortality.Observational multicentre retrospective that presented a infection. For each case, four periods exposure analysed: P1: pre-IBD diagnosis, P2: from diagnosis immunosuppressant initiation, P3: during...
Eleven episodes of spontaneous bacterial empyema were identified in eight cirrhotic patients with ascites. Criteria for included positive pleural fluid culture or polymorphonuclear cell concentration greater than 500 cells/mm3, evidence effusion before an infectious episode and transudate characteristics during infection. In five cases, was culture-negative associated peritonitis. Ascitic two these cases culture-positive three. Blood cultures negative all cases. six (Escherichia coli four,...
In this study, we aim to identify the genes responsible for colorectal cancer risk behind loci identified in genome-wide association studies (GWAS). These may be candidate targets developing new strategies prevention or therapy. We analyzed of genotypes 26 GWAS single nucleotide polymorphisms (SNPs) with expression within a 2 Mb region (cis-eQTLs). Affymetrix Human Genome U219 arrays were used assess gene two series samples, one healthy colonic mucosa (n = 47) and other normal adjacent colon...