Belén Botella
A5013169894- Inflammatory Bowel Disease
- Microscopic Colitis
- Pregnancy and Medication Impact
- Anorectal Disease Treatments and Outcomes
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
- Diagnosis and treatment of tuberculosis
- Mycobacterium research and diagnosis
- Reproductive System and Pregnancy
- Hidradenitis Suppurativa and Treatments
- Immunodeficiency and Autoimmune Disorders
- Tuberculosis Research and Epidemiology
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Infectious Diseases and Tuberculosis
- Diverticular Disease and Complications
- Gastrointestinal disorders and treatments
- Systemic Lupus Erythematosus Research
- Adolescent and Pediatric Healthcare
- Respiratory viral infections research
- Biosimilars and Bioanalytical Methods
- Stoma care and complications
- Oral Health Pathology and Treatment
Hospital Universitario Puerta de Hierro Majadahonda
2025
Hospital Universitario Infanta Cristina
2012-2024
Universidad Autónoma de Madrid
2019
Hospital Universitario de La Princesa
2019
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2019
Hospital Universitario De Cabueñes
2014
The safety of thiopurines and anti-tumor necrosis factor-α (TNF-α) drugs during pregnancy remains controversial, as the experience with these in this situation is limited. Our aim to assess anti-TNF-α for treatment inflammatory bowel disease (IBD) pregnancy.Retrospective, multicenter study IBD patients. Pregnancies were classified according therapeutic regimens or 3 months before conception: non-exposed group, pregnancies exposed alone (group A), B). An unfavorable Global Pregnancy Outcome...
The aims of this study were to assess the risk relapse after discontinuation anti-tumor necrosis factor (anti-TNF) drugs in patients with inflammatory bowel disease (IBD), identify factors associated relapse, and evaluate overcome retreatment same anti-TNF those who relapsed.This was a retrospective, observational, multicenter study. IBD had been treated anti-TNFs whom these discontinued clinical remission achieved included.A total 1,055 included. incidence rate 19% 17% per patient-year...
(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe main epidemiological and clinical characteristics at diagnosis evolution disease, explore use drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 Spain were included followed-up for 1 year. (3) Results: We identified 3611 incident cases during 108 hospitals...
Data regarding the effectiveness of adalimumab (ADA) in treatment perianal fistula patients with Crohn's disease (CD) naive to antitumor necrosis factor (TNF) therapy are scarce.: To assess ADA fistulas CD anti-TNF therapy.A retrospective multicenter study was designed. The Fistula Drainage Assessment Index used clinical response, and Van Assche Ng indexes classify radiologic response (magnetic resonance imaging).A total 46 (83% women, 83% complex fistula) were included. At 6 months, 72%...
Background There is limited evidence on the effectiveness of biological therapy in stricturing complications patients with Crohn’s disease. Aim The study aims to determine anti‐tumor necrosis factor (TNF) agents disease complicated symptomatic strictures. Methods In this multicentric and retrospective study, we included adult receiving their first anti‐TNF therapy, no previous history biological, endoscopic or surgical therapy. agent was defined as a composite outcome combining steroid‐free...
INTRODUCTION: The objective of this study was to assess the durability, short-term and long-term effectiveness, safety tofacitinib in ulcerative colitis (UC) clinical practice. METHODS: This is a retrospective multicenter including patients with UC who had received first dose at least 8 weeks before inclusion. Clinical effectiveness based on partial Mayo score. RESULTS: A total 408 were included. Of them, 184 (45%) withdrew during follow-up (mean = 18 months). probability maintaining 67% 6...
Abstract Background Upadacitinib (UPA) is the first oral JAK inhibitor approved for treatment of Crohn's disease (CD). While its effectiveness and safety are well-documented in pivotal clinical trials, real-world data remain limited. Aim: To evaluate efficacy UPA both short long term CD patients. Methods A multicentre, prospective, observational study was conducted on patients receiving since approval. Epidemiological, disease-related variables, cardiovascular risk factors (CVRF) prior...
Abstract Background Tofacitinib, filgotinib, and upadacitinib, are Janus kinase inhibitors (iJAKs) approved for inflammatory bowel disease (IBD) treatment. Although no comparative studies exist, potential differences in efficacy safety attributed to vitro-demonstrated affinity of each molecule different JAK isoforms. JAK1 plays a crucial role modulating cytokine-mediated immune responses, such as IL-6 interferon, which involved inflammation skin homeostasis. Its inhibition can promote...
Patients with colonic inflammatory bowel disease (IBD) have a high risk of colorectal cancer (CRC). Current guidelines recommend endoscopic surveillance, yet epidemiological studies show poor compliance. The aims our study were to analyse adherence its impact on advanced lesions, and factors non-adherence.A retrospective multicentre IBD patients criteria for CRC diagnosed between 2005 2008 followed up 2020, was performed. Following European guidelines, stratified into groups considered when...
Beclometasone dipropionate (BDP) is a relatively new topically acting oral steroid to treat mild moderately active ulcerative colitis (UC). We estimate that 20,000 patients have received BDP in Spain the last two years. Our aim was evaluate efficacy and safety of clinical practice.Retrospective multicenter study included 434 with UC treated BDP. The partial Mayo Clinic score (pMS, 0-9) used measure disease activity. Remission defined as post-treatment pMS 0 or 1; response decrease 3 points 2...
Sensitivity of tuberculin skin test [TST] during screening for latent tuberculosis infection [LTBI] is affected by steroid and/or immunosuppressant therapy. The aim this study was to compare performance the two-step TST in inflammatory bowel disease patients immediately before anti-tumour necrosis factor [TNF] therapy as part routine LTBI vs control when carried out at an early stage.In multicentre prospective controlled study, we evaluated with 5-mm threshold. Factors associated results...
To assess the likelihood of detecting latent tuberculosis infection [LTBI] by positive conversion a serial tuberculin skin test [TST] at 1 year in inflammatory bowel disease [IBD] patients with negative baseline two-step TST.In this multicentre prospective cohort study, we evaluated rate and predictors TST TST. We also management who had or year. In all assessed TB cases occurring during follow-up.Of 192 IBD receiving anti-tumour necrosis factor [TNF] 220 controls not anti-TNF, 35 [8.5%, 95%...
(1) Background: Transition is a planned movement of paediatric patients to adult healthcare systems, and its implementation not yet established in all inflammatory bowel disease (IBD) units. The aim the study was evaluate impact transition on IBD outcomes. (2) Methods: Multicentre, retrospective observational transferred an unit between 2017-2020. Two groups were compared: (≥1 joint visit involving gastroenterologist, paediatrician, programme coordinator, parents patient) no-transition....
Introduction:The internet is emerging as a source of information for patients with inflammatory bowel disease (IBD). However, it not always reliable and may cause anxiety. We aim to assess patients' habits professionals' perceptions national website integrated an educational resource the IBD unit.Methods:Patients aged 18-65 years, comfortable internet, attending follow-ups at participating units (March-June 2019) their professionals were invited evaluate recommended through online...
Clinical: Therapy and observation S225 our preliminary experience suggested that oral B12 could also be effective in CD.Objective: To analyze the efficacy of route to treat deficiency CD within a large group patients, confirm its convenience.Methods: We performed retrospective analysis patients treated by cobalamin, 4 centers following quite similar protocol.CD diagnosis was established Lennard-Jones criteria Montreal Classification used.Data on previous surgery, concomitant drugs...
Background: Inflammatory Bowel Diseases (IBD) are associated with systemic inflammation and hypercoagulability.Chronic is a well-known factor of atherosclerosis, but few data showed an over-risk cardiovascular events in IBD patients.The objective this study was to evaluate the prevalence patients compared general population.Methods: Between 2004 2013, historic longitudinal cohort has been performed, analyzing from French regional registers (SNIIRAM) patients' health care system (ALD).A...
Abstract Background Hidradenitis suppurativa (HS) is a relapsing skin disease. Evidence supports an association between HS and inflammatory bowel disease(IBD). Aim, to explore the characteristics of patients with IBD HS(IBD-HS) compare without HS(controls). Methods Retrospective, observational, multi-centre, case-control study Spanish nationwide ENEIDA registry. We selected all confirmed by dermatologist. Patients were matched 2:1 hospital year diagnosis controls. A form regarding was...