A5028505609- Inflammatory Bowel Disease
- Microscopic Colitis
- Gut microbiota and health
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders
- Celiac Disease Research and Management
- Eosinophilic Esophagitis
- Plant Virus Research Studies
- COVID-19 and healthcare impacts
- Plant Pathogens and Fungal Diseases
- Chronic Lymphocytic Leukemia Research
- Health Systems, Economic Evaluations, Quality of Life
- Biosimilars and Bioanalytical Methods
- Pregnancy and Medication Impact
- Colorectal Cancer Screening and Detection
- Plant and Fungal Interactions Research
- COVID-19 Clinical Research Studies
- Insect-Plant Interactions and Control
- Reproductive System and Pregnancy
- Probiotics and Fermented Foods
- Diagnosis and treatment of tuberculosis
- Acute Lymphoblastic Leukemia research
- Gastrointestinal Tumor Research and Treatment
- COVID-19 and Mental Health
- Diverticular Disease and Complications
Vall d'Hebron Hospital Universitari
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2014-2023
Vall d'Hebron Institut de Recerca
2020-2022
Universitat de Lleida
2021
East Malling Research (United Kingdom)
1992-2001
The concept of beneficial microbes was first suggested by Elie Metchnikoff who postulated that lactic acid bacteria offered health benefits capable promoting longevity. Disorders the intestinal tract were frequently treated with viable nonpathogenic to change or replace microbiota. German professor Alfred Nissle isolated a strain Escherichia coli from feces First World War soldier did not develop enterocolitis during severe outbreak shigellosis. In Japan, Dr. Minoru Shirota...
Abstract Background Microbiome studies report low gut microbial richness and diversity in ulcerative colitis (UC) patients. We explored whether UC patients who reach long-term clinical, endoscopic, histological remission show a ecosystem that is similar to healthy individuals. Methods collected 184 stool samples from 111 individuals (UC long remission, short flare, control subjects). Microbiota was analyzed by amplicon sequencing (16S ribosomal RNA) quantitative polymerase chain reaction for...
Mycoplasma‐like organisms (MLOs) were detected by fluorescence microscopy in a number of pear cultivars and seedlings growing under range different conditions. In the cultivar Conference, MLOs consistently associated with symptoms Parry's disease, decline‐like disease young trees quince rootstocks. MLO‐free rapidly became infected when they planted outside. Experimental transmission to Conference was achieved using psyllids, caught outside or raised on plants controlled an orchard trial...
Anemia is a common complication of inflammatory bowel disease (IBD) and contributes to the deterioration health-related quality life (HRQOL). Iron deficiency (ID) prevalent underlying factor, present in up 90% patients. In absence anemia, it unclear as what extent ID can affect HRQOL patients with IBD. Our aim was determine whether without anemia negatively affects normal perception IBD remission.We conducted prospective, cross-sectional study remission anemia. Blood samples were obtained...
Background There is limited evidence on the effectiveness of biological therapy in stricturing complications patients with Crohn’s disease. Aim The study aims to determine anti‐tumor necrosis factor (TNF) agents disease complicated symptomatic strictures. Methods In this multicentric and retrospective study, we included adult receiving their first anti‐TNF therapy, no previous history biological, endoscopic or surgical therapy. agent was defined as a composite outcome combining steroid‐free...
Microbiome sequence data have been used to characterize Crohn's disease (CD) and ulcerative colitis (UC). Based on these data, we previously identified microbiomarkers at the genus level predict CD relapse. However, microbial load was underexplored as a potential biomarker in inflammatory bowel (IBD). Here, sought study use of fungal bacterial loads biomarkers detect both UC We analyzed fecal 294 stool samples obtained from 206 participants using real-time PCR amplification ITS2 region 16S...
Abstract Background In inflammatory bowel disease, altered microbial states of the gut ecosystem could influence response to treatment. Our objective was investigate possibility predicting vedolizumab using markers microbiome. Methods To this end, we analysed characteristics microbiome shotgun metagenomic sequencing in 21 patients with active ulcerative colitis, eligible for treatment vedolizumab. The protocol included assessment clinical activity and analysis faecal samples prior at weeks...
Abstract Background Sexual dysfunction (SD) is common in patients with Inflammatory Bowel Disease (IBD), yet previous research identified depression as a key confounding factor. This the first study to exclude participants depression, aiming isolate impact of IBD on sexual health. Methods Adults confirmed and non-IBD controls were enrolled. A Hospital Anxiety Depression Scale1 (HADS) score >16 was an exclusion criteria. function assessed validated tools: Desire Inventory2 (SDI) for...
Abstract Background Despite the high prevalence of diverticulosis in population, segmental colitis associated with (SCAD) is uncommon. Due to its overlap characteristics typical inflammatory bowel diseases, especially Ulcerative Colitis (UC), a possible link pathogenesis has been postulated, some cases disease progression from one other described. We present series SCAD that progressed UC Methods describe followed at our IBD Unit Hospital Universitari Vall d’Hebron were subsequently...
Abstract Background Ustekinumab (UST) is a monoclonal antibody targeting the p40 subunit of interleukin-12/23. Evidence suggests relationship between UST concentrations and therapeutic outcomes. This study aimed to evaluate association trough during induction phase clinical especially endoscopic outcomes at week 24 in patients with Crohn’s disease (CD) ulcerative colitis (UC). Methods Patients CD UC were included from start treatment. Intensification maintenance regimens based on standard...
BackgroundThe remission of Crohn's disease (CD) can be accomplished by faecal microbiota transplantation (FMT). However, this procedure has a low success rate, which could attributed to mis-communication between recipient intestinal mucosa and donor microbiota.MethodsHere we used human explant tissue model an in vivo mouse examine changes upon contact with suspension (FS) obtained from healthy donor. CD patients provided resected inflamed non-inflamed mucosal tissues, whereas control colonic...
Abstract Background Vedolizumab (VDZ) is a selective biologic agent that available in both intravenous (IV) and subcutaneous (SC) forms for maintenance treatment. The SC route offers advantages such as the convenience of self-administration, although some patients may prefer IV route. aim our study was to determine patients’ preferences satisfaction with their treatment when switching VDZ or continuing an administration. Methods A prospective, observational conducted inflammatory bowel...
immune checkpoint inhibitors (ICI) are increasingly used to treat several types of cancer. These drugs lead a wide range toxicities. Immune-related gastrointestinal adverse events common and potentially severe. In this manuscript, we recount the real clinical experience in tertiary center.a retrospective observational study was conducted adult patients under ICI treatment. Included had been referred Gastrointestinal Service Hospital Universitario Vall d'Hebron for evaluation severe...
Objective: To evaluate the effectiveness and safety of combination granulocyte–monocyte apheresis (GMA) after loss response (LOR) to anti-tumor necrosis factor (TNF) agents in ulcerative colitis (UC).Materials methods: A retrospective, multicenter study was performed 11 inflammatory bowel disease (IBD) Units. Clinical remission defined as a partial Mayo score ≤2. The treatment evaluated by rate anti-TNF intensification, switch, swap or colectomy.Results: Forty-seven patients with were...
Crohn's disease (CD) impairs patients' health-related quality of life (HRQoL), therefore a goal treatment is to improve their health. Recently, more ambitious therapeutic target has been proposed, reestablish HRQoL normal standards. There no information on long-term prognostic value restoring the health patients with CD. Our aim was determine if early restoration antitumor necrosis factor (anti-TNF) agents associated clinical remission.Retrospective longitudinal study in active CD treated...
BackgroundIn recent years anti-TNF therapy has been associated with leishmaniasis in immunocompromised patients from endemic areas. Nevertheless, data on asymptomatic Leishmania infection such is scarce. The aim of this study was to determine the prevalence inflammatory bowel disease (IBD) treated TNF inhibitors living an area (Catalonia) and follow up them how evolved.Methods192 IBD (143 Crohn's disease; 49 ulcerative colitis) Catalonia (Spain), for L. infantum, were recruited. Peripheral...
Iron deficiency anemia (IDA) is a common manifestation of Inflammatory Bowel Disease (IBD). Oral iron supplements are the treatment choice, but not always well tolerated. Sucrosomial® (SI) may represent an alternative. This prospective study assessed tolerability and effectiveness SI, quality life (QoL) IDA-IBD patients who were intolerant to oral salts. The included 52 individuals treated with 1 capsule/day for 12 weeks. Tolerability was through gastrointestinal symptom severity...
To report the impact of COVID-19 pandemic on activity nurses working an inflammatory bowel disease (IBD) unit and to identify reasons for telehealth care its relationship certain characteristics. The had led increase in demand remote patients with who require monitoring frequent access health services. A retrospective study all (in person by phone call or email) done during acute phase at a reference hospital Spain. Numbers activities nurses, sociodemographic clinical data were collected....
ustekinumab is a fully human monoclonal antibody against IL-12/23, approved for induction and maintenance treatment of Crohn's disease (CD). Real-life data shows its true effectiveness in terms clinical endoscopic response. However, there little information regarding health-related quality life (HRQoL) CD patients receiving ustekinumab. The main aim this study was to define long-term remission HRQoL normalization. predictive factors were investigated as secondary aim.a retrospective,...