A5014674437- Inflammatory Bowel Disease
- Microscopic Colitis
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Dysphagia Assessment and Management
- Autoimmune and Inflammatory Disorders
- IL-33, ST2, and ILC Pathways
- Reproductive System and Pregnancy
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Liver Diseases and Immunity
- Pregnancy and Medication Impact
- Acute Lymphoblastic Leukemia research
- Liver Disease and Transplantation
- Epigenetics and DNA Methylation
- Drug-Induced Hepatotoxicity and Protection
- Respiratory Support and Mechanisms
- Diverticular Disease and Complications
- Gallbladder and Bile Duct Disorders
- Celiac Disease Research and Management
- Infant Nutrition and Health
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Enhanced Recovery After Surgery
Hospital Universitari i Politècnic La Fe
2015-2024
Instituto de Investigación Sanitaria La Fe
2018-2023
Centro de Investigación Biomédica en Red
2018-2023
Leitat Technological Center
2017-2021
Vitamin D has recently been discovered to be a potential immune modulator. Low serum vitamin levels have associated with risk of relapse and exacerbation clinical outcomes in Crohn’s disease (CD) ulcerative colitis (UC). A retrospective, longitudinal study was conducted determine the association between inflammatory markers activity bowel (IBD). In addition, circulating 25(OH)D3 progression evaluated according supplementation. Participants were separated into three groups their level: severe...
<b><i>Introduction:</i></b> The association between infliximab (IFX) and fecal calprotectin (FC) levels on one hand, the clinical endoscopic response of patients with inflammatory bowel disease other, is well established. <b><i>Objective Methods:</i></b> To investigate biochemical parameters serum concentrations IFX during induction treatment a primary nonresponse in prospective cohort Crohn’s (CD) patients....
Abstract Background The aims of this study were to characterize the immune response profile in patients with Crohn’s disease (CD) and early postoperative recurrence (POR), identify predictive biomarkers, develop a noninvasive tool for individual estimation POR risk. Methods Sixty-one who had undergone ileocolonic resection CD prospectively included followed up 24 months. Fecal calprotectin (FC), analytical parameters, plasma cytokines obtained before surgery at various time points during...
Esteban S?ez Gonz?lez, Vicente Ortiz Bellver, Francia Carolina D?az Jaime, Juan Antonio Ortu?o Cort?s, and Garrigues Gil. J Neurogastroenterol Motil 2015;21:618-20. https://doi.org/10.5056/jnm15108
INTRODUCTION: DNA methylation is an epigenetic mechanism that regulates gene expression and represents important link between genotype, environment, disease. It a reversible inheritable could offer treatment targets. We aimed to assess the changes on specific genes previously associated with Crohn's disease (CD) study their possible associations pathology. METHODS: included 103 participants grouped them into 2 cohorts (a first [n = 31] second validation 72] cohort), active CD (aCD) inactive...
Little is known about the association between pharmacokinetic features of adalimumab (ADL) and disease outcome in patients with inflammatory bowel (IBD).To assess random serum ADL levels clinical or biochemical remission decision making daily practice according to these levels; determine cutoff value for successful dose reduction IBD treated ADL.We conducted a prospective observational study who received long-term maintenance therapy ADL.Data were available 157 samples from 87 patients....
Abstract Background Therapies for hepatitis C virus ( HCV ) infection have revolutionized the treatment of patients with chronic infection. The effect these therapies on epidemiology liver transplantation LT has yet to be elucidated. Aim To establish whether indications changed as a result introduction new . Materials and methods We conducted retrospective study based prospectively maintained registry who undergo at La Fe Hospital in Valencia from 1997 2016. An analysis outcome measures over...
To assess the effectiveness and safety of combining granulocyte-monocyte apheresis (GMA) vedolizumab (VDZ) in patients with refractory ulcerative colitis (UC).This retrospective, multicentre pilot study included all UC receiving both GMA VDZ. We recorded data on sessions, demographic characteristics, clinical response. Effectiveness was assessed 1 6 months after finishing using partial Mayo score, C-reactive protein, fecal calprotectin levels. Data were also compiled VDZ intensification, use...
Vicente Ortiz, Diego Alvarez-Sotomayor, Esteban Sáez-González, Francia Carolina Díaz-Jaime, Marisa Iborra, Julio Ponce, and Garrigues. Gut Liver 2017;11:358-62. https://doi.org/10.5009/gnl16081
Olmesartan is one of the various angiotensin II antagonists currently used for management high blood pressure. A sprue-like enteropathy was first described in 2012 association with this antihypertensive drug. An observational, descriptive study carried out on a series 12 patients who met clinical, histopathological, and outcome criteria olmesartan-related from May 2013 to December 2015. All had watery diarrhea, weight loss, negative celiac serology. They all were admitted severe illness...
Abstract Background There are limited data in real-life of ustekinumab (USK) used ulcerative colitis (UC). The aim this study was to assess the effectiveness and safety clinical practice USK UC medium long-term. Methods Observational patients who received at recommended dose based on weight ~6 mg/kg IV week, 0.90 mg SC 8 maintenance, 90 every, or, 12 weeks with, 1 year follow-up. partial Mayo score (PMS) remission (PMS≤, 2). PMS, C-reactive protein (CRP) faecal calprotectin (FC) values...
Abstract Background Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract, affecting millions individuals throughout world, and producing impaired health‐related quality life. Granulocyte monocyte apheresis (GMA) a therapeutic option for UC management to induce remission selective removal activated leukocytes from bloodstream. Despite knowledge important role epigenetics in pathogenesis, response different treatments,...
to assess the usefulness, efficacy and safety of single-operator cholangiopancreatoscopy (SOCP) with SpyGlass™ system for management biliopancreatic diseases.a retrospective analysis patients undergoing SOCP between September 2008 April 2016 was performed. Data obtained from a prospectively-maintained database at tertiary referral center. The primary study outcomes were technical complete endoscopic success procedure. Two different systems employed; former is called legacy latter, digital...
Iron deficiency anemia (IDA) is a common manifestation of Inflammatory Bowel Disease (IBD). Oral iron supplements are the treatment choice, but not always well tolerated. Sucrosomial® (SI) may represent an alternative. This prospective study assessed tolerability and effectiveness SI, quality life (QoL) IDA-IBD patients who were intolerant to oral salts. The included 52 individuals treated with 1 capsule/day for 12 weeks. Tolerability was through gastrointestinal symptom severity...
Introduction Patient blood management (PBM) adherence in clinical practice is unclear. This real-world study assessed the of patients with gastrointestinal (GI) bleeding after implementation PBM strategy. Methods was a nationwide multicenter and prospective involving consecutive adults GI between March 2019 2021. Patients were examined according to hemoglobin (Hb) level at admission (<7 g/dl, n = 93; 7–8 47; 8–9 61; >9 249). Study outcomes measures morbidity mortality during...
Ischemic colitis (IC) is an uncommon adverse event associated with antipsychotic agents, more commonly found phenothiazine drugs and atypical neuroleptics such as clozapine. The risk of developing ischemic increases when anticholinergic are associated. We report the case a 38-year-old woman history schizoaffective disorder who had been on chronic quetiapine for 3 years, presented to ER because diarrhea 5 days. Four months previously, olanzapine added her psychiatric drug regimen. Physical...
MicroRNAs (miRNAs) are important epigenetic regulators in Crohn's disease (CD); however, their contribution to postoperative recurrence (POR) is still unknown. We aimed characterize the potential role of miRNAs predicting POR patients with CD and identify pathogenic implications.Of 67 consecutively operated CD, we included 44 pure ileal CD. Peripheral blood samples were taken before surgery during follow-up. The classified according presence or absence assessed by ileocolonoscopy magnetic...