A5090655982- Inflammatory Bowel Disease
- Immune responses and vaccinations
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Occupational and environmental lung diseases
- Inflammasome and immune disorders
- COVID-19 Clinical Research Studies
- Gynecological conditions and treatments
- T-cell and B-cell Immunology
- Respiratory Support and Mechanisms
- Uterine Myomas and Treatments
- Long-Term Effects of COVID-19
- Helicobacter pylori-related gastroenterology studies
- Pancreatitis Pathology and Treatment
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders
- IL-33, ST2, and ILC Pathways
- Tuberculosis Research and Epidemiology
- RNA Interference and Gene Delivery
- Alkaline Phosphatase Research Studies
- Maternal and fetal healthcare
Instituto de Investigación Sanitaria La Fe
2015-2024
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2015-2023
Hospital Universitari i Politècnic La Fe
2023
Centro de Investigación Biomédica en Red
2023
Leitat Technological Center
2021-2022
Unité de Nutrition Humaine
2015
Université Clermont Auvergne
2015
Imperial College London
2015
Inserm
2015
Microbe, Intestine, Inflammation and Host Susceptibility
2015
INTRODUCTION: DNA methylation is an epigenetic mechanism that regulates gene expression and represents important link between genotype, environment, disease. It a reversible inheritable could offer treatment targets. We aimed to assess the changes on specific genes previously associated with Crohn's disease (CD) study their possible associations pathology. METHODS: included 103 participants grouped them into 2 cohorts (a first [n = 31] second validation 72] cohort), active CD (aCD) inactive...
Abstract STUDY QUESTION Can human umbilical cord platelet-rich plasma (hUC-PRP) efficiently treat endometrial damage and restore fertility in a preclinical murine model? SUMMARY ANSWER Local application of hUC-PRP promotes tissue regeneration restoration model Asherman syndrome atrophy (AS/EA). WHAT IS KNOWN ALREADY AS/EA are well-described pathologies that cause infertility; however, there currently no gold-standard treatments available. Recent reports have described the successful use...
Abstract Background Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract, affecting millions individuals throughout world, and producing impaired health‐related quality life. Granulocyte monocyte apheresis (GMA) a therapeutic option for UC management to induce remission selective removal activated leukocytes from bloodstream. Despite knowledge important role epigenetics in pathogenesis, response different treatments,...
MicroRNAs (miRNAs) are important epigenetic regulators in Crohn's disease (CD); however, their contribution to postoperative recurrence (POR) is still unknown. We aimed characterize the potential role of miRNAs predicting POR patients with CD and identify pathogenic implications.Of 67 consecutively operated CD, we included 44 pure ileal CD. Peripheral blood samples were taken before surgery during follow-up. The classified according presence or absence assessed by ileocolonoscopy magnetic...
Abstract Crohn’s disease (CD) is a chronic relapsing inflammatory disorder in which defective apoptosis of mucosal T cells postulated to produce sustained inflammation and reactive oxygen species accumulation. Whether CD are intrinsically resistant or whether this resistance acquired at the intestinal site needs be clarified, as cellular mechanisms modulate impaired these cells. Here, we analysed peripheral blood from patients naïve specific treatment onset healthy controls. Non-activated...
Background: A high prevalence of the adherent-invasive E. coli (AIEC) in intestinal mucosa Crohn's disease patients has been shown.We previously showed that upon AIEC infection, autophagy is induced host cells to restrain intracellular replication.The mechanism underlying such induction, however, remains largely unknown.Here, we investigated role GCN2/eIF2α/ ATF4 pathway response infection.Methods: Autophagic activity was assessed by Western blot and immunofluorescent labelling...