A5044797857- Inflammatory Bowel Disease
- Celiac Disease Research and Management
- Microscopic Colitis
- Digestive system and related health
- Eosinophilic Esophagitis
- Adolescent and Pediatric Healthcare
- Gastrointestinal motility and disorders
- Gastrointestinal disorders and treatments
- Microbial Metabolites in Food Biotechnology
- COVID-19 and healthcare impacts
- Intestinal Malrotation and Obstruction Disorders
- Telemedicine and Telehealth Implementation
- Food Allergy and Anaphylaxis Research
- Childhood Cancer Survivors' Quality of Life
- Nutrition, Genetics, and Disease
- Infant Nutrition and Health
- Mobile Health and mHealth Applications
- Acute Lymphoblastic Leukemia research
- Consumer Attitudes and Food Labeling
- Gut microbiota and health
- Heart Failure Treatment and Management
- Child and Adolescent Health
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Function and Risk Factors
- Genetic factors in colorectal cancer
Hospital Regional Universitario de Málaga
2019-2025
Hospital Materno-Infantil
2019-2025
Universidad de Málaga
2024
Universidad de Granada
2020-2023
Instituto de Investigación Biomédica de Málaga
2022-2023
Hospital Universitario Virgen de las Nieves
2019
Complejo Hospitalario Universitario de Granada
2017
The current study assesses whether the use of a gluten-free diet (GFD) is sufficient for maintaining correct iron status in children with celiac disease (CD). included 101 children. group (n = 68) CD, long (> 6 months) 47) or recent (< 21) adherence to GFD. control 43) healthy Dietary assessment was performed by food frequency questionnaire and 3-day record. Celiac had lower intake than controls, especially at beginning GFD (p < 0.01). CD-GFD >6 months showed higher cobalamin,...
Exclusive enteral nutrition (EEN) has been shown to be more effective than corticosteroids in achieving mucosal healing children with Crohn´s disease (CD) without the adverse effects of these drugs. The aims this study were determine efficacy EEN terms inducing clinical remission newly diagnosed CD, describe predictive factors response and need for treatment biological agents during first 12 months disease. We conducted an observational retrospective multicentre that included paediatric...
We aimed to assess the influence of Mediterranean Diet adherence and physical activity (PA) on body composition, with a particular focus bone health, in young patients celiac disease (CD). The CD group (n = 59) included children long (>18 months, n 41) or recent (<18 18) gluten-free diet (GFD). non-celiac 40) children. After adjusting for potential confounders, showed lower weight (p 0.034), lean mass 0.003), mineral content 0.006), Z-score 0.036) than children, even when model was...
Abstract Background A Western dietary pattern characteristics was suggested to have a role in the pathogenesis of ulcerative colitis (UC). Poor can exacerbate patients’ symptoms and lead significant nutrient deficiencies. However, data regarding habits nutritional needs are scarce. Our study aimed prospectively evaluate intake peadiatric patients with UC at Spanish tertiary hospital. Methods In this prospective observational study, were followed up, during which their collected. Patients...
The SARS-CoV-2 virus and its rapid spread have made it a global health concern. aim of this was to investigate the microbial metabolic faecal profiles paediatric patients hospitalised for COVID-19 try identify biomarkers predisposition severity. study included 16 (aged 4–14 years old) from six different Spanish hospitals 20 age-matched healthy controls. gut microbiota characterised by sequencing 16S rDNA amplicons internal transcribed space amplicons, while profile analysed liquid...
The current study was designed to assess the influence of consumption ultra-processed (UPF) on oxidative/antioxidant balance and evoked inflammatory signaling in young patients with celiac disease (CD). included 85 children. group (n = 53) children CD a long (>18 months, n 17) or recent (<18 36) adherence gluten-free diet (GFD). control 32) healthy significantly lower UPF compared group, both expressed as kcal/day (p 0.043) percentage daily energy intake 0.023). Among CD, lowest (below...
Gut microbiota alterations play a key role in the pathogenesis of inflammatory bowel disease (IBD), and its modification through specific diets is an emerging line treatment that currently being researched. The aim this study was to assess changes dietary habits patients with Crohn’s (CD) their long-term adherence therapy exclusion diet (CDED) after one year. To analyse Mediterranean (DM), KIDMED questionnaire, food consumption frequency used. Twenty-four hour recalls at two timepoints,...
Celiac disease (CeD) is an immune-mediated disorder triggered by gluten ingestion that damages the small intestine. Although CeD has been associated with a higher risk for cancer, role of as factor specific malignancies, such enteropathy-associated T-cell lymphoma (EATL), remains controversial. Using two-sample Mendelian randomization (2SMR) methods and summarized results large genome-wide association studies from public repositories, we addressed causal relationship between eight different...
The World Health Organization recommends exclusive breastfeeding on demand until at least the sixth month of life. Breast milk or infant formula is infant’s primary food source age one year, followed by gradual introduction other foods. During weaning, intestinal microbiota evolves to a profile close that adult, and its disruption can result in an increased incidence acute infectious diseases. We aimed determine whether novel starting (INN) provides gut compositions more similar those...
(1) Background: Pediatric dysphagia presents significant nutritional challenges, often impacting growth and development due to reduced oral intake, increased needs, gastrointestinal complications; (2) Methods: This prospective quasi-experimental study assessed 117 children under 14 years old (20 patients were 1 year old, 80 aged 1–7 years, 17 older than 7 years), diagnosed with swallowing disorders, analyze their caloric, macro-, micronutrient intake identify potential deficiencies. The...
Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to one-carbon To date, no targeted metabolomics analysis investigating differences the plasma choline/methionine metabolome CD subjects are reported. This work a metabolomic study that analyzes 37 metabolites metabolism 17 children CD, treated gluten-free...
Background and Aims: Diagnostic delay (DD) is especially relevant in children with inflammatory bowel disease, leading to potential complications. We examined the intervals factors for DD pediatric population of Spain. Methods: conducted a multicentric prospective study, including 149 disease patients, obtaining clinical, anthropometric, biochemical data. Time diagnosis (TD) was divided into several identify those where longer find variables that prolonged intervals. Missed opportunities...
(1) Background: Transition is a planned movement of paediatric patients to adult healthcare systems, and its implementation not yet established in all inflammatory bowel disease (IBD) units. The aim the study was evaluate impact transition on IBD outcomes. (2) Methods: Multicentre, retrospective observational transferred an unit between 2017-2020. Two groups were compared: (≥1 joint visit involving gastroenterologist, paediatrician, programme coordinator, parents patient) no-transition....
Inflammatory Bowel Diseases (IBD) are a group of chronic, inflammatory disorders the gut. The incidence and activity IBD determined by both genetic environmental factors. Among these factors, polymorphisms in genes related to autophagy consumption non-steroidal anti-inflammatory drugs (NSAIDs) have been consistently associated with IBD. We show that NSAIDs induce mitochondrial stress mitophagy intestinal epithelial cells. In an altered context simulating observed patients, NSAID-induced...
Introduction. The WPAI-UC/CD-Caregiver questionnaires assess the impact of ulcerative colitis (UC) or Crohn's disease (CD) on parents'/caregivers' work life and daily activities. Our objective was to adapt validate these in Spanish population. Methods. A translation back-translation were done. document assessed by an expert committee a pilot group families patients with pediatric inflammatory bowel (p-IBD). For validation, parents/caregivers p-IBD (10-18 years old) recruited. conducted...
Celiac disease (CD) is an autoimmune enteropathy linked to alterations of metabolism. Currently, limited untargeted metabolomic studies evaluating differences in the plasma metabolome CD subjects have been documented. We engage a study that analyzes 17 children with treated gluten-free diet and healthy control siblings order recognize potential changes metabolic networks. Our data demonstrates persistence defects spite dietary treatment, affecting minor but significant fraction (around 4%,...