Beatriz Castro
A5043698257- Inflammatory Bowel Disease
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Pregnancy and Medication Impact
- Eosinophilic Esophagitis
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Diverticular Disease and Complications
- Ovarian cancer diagnosis and treatment
- Immunodeficiency and Autoimmune Disorders
- Liver Disease and Transplantation
- Bacterial biofilms and quorum sensing
- Liver Diseases and Immunity
- Migraine and Headache Studies
- Appendicitis Diagnosis and Management
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac Valve Diseases and Treatments
- Celiac Disease Research and Management
- Diagnosis and treatment of tuberculosis
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal disorders and treatments
Marqués de Valdecilla University Hospital
2016-2025
Instituto de Investigación Marqués de Valdecilla
2016-2025
Hospital Universitario de Canarias
2012-2025
Universidad de Cantabria
2017-2024
Fundação de Amparo à Pesquisa do Estado da Bahia
2022
Universidade Federal de Goiás
2022
Universidad de Salamanca
2021
Universidade Federal de Mato Grosso
2020
Graco (United States)
2020
Instituto de Saúde
2020
The "fitness" of an infectious pathogen is defined as the ability to survive, reproduce, be transmitted, and cause disease. fitness multidrug-resistant tuberculosis (MDRTB) relative drug-susceptible cited one most important determinants MDRTB spread epidemic size. To estimate drug-resistant cases, we compared incidence disease among household contacts index patients that patients.This 3-y (2010-2013) prospective cohort follow-up study in South Lima Callao, Peru, measured 1,055 213 cases...
In vivo muscle function testing has become of great interest as primary phenotypic analysis performance. This protocol provides detailed procedures to perform the treadmill exhaustion test and whole-limb grip strength assay, two methods commonly used in neuromuscular research field.
Liposarcomas (LPSs) are the most common soft-tissue cancer. Because of lack animal models, cellular origin and molecular regulation LPS remain unclear. Here, we report that mice with adipocyte-specific activation Notch signaling (Ad/N1ICD) develop complete penetrance. Lineage tracing confirms adipocyte Ad/N1ICD LPS. The resembles human dedifferentiated in histological appearance, anatomical localization, gene expression signature. Before transformation, adipocytes undergo dedifferentiation...
The aims of this study were to determine the prevalence fatigue in patients with inflammatory bowel disease [IBD], identify factors associated and its severity, assess impact on quality life [QoL], evaluate relationship between sleep disorders.This was a prospective multicentre conducted at 22 Spanish centres. Consecutive followed IBD Units included. Fatigue evaluated Severity Scale [FSS] Impact [FIS]. Quality assessed using Questionnaire-Short Form [IBDQ-9] Pittsburgh Sleep Index [PSQI],...
The development programm UNIFI has shown promising results of ustekinumab in ulcerative colitis [UC] treatment which should be confirmed clinical practice. We aimed to evaluate the durability, effectiveness, and safety UC real life.Patients included prospectively maintained ENEIDA registry, who received at least one intravenous dose due active [Partial Mayo Score [PMS]>2], were included. Clinical activity effectiveness defined based on PMS. Short-term response was assessed Week 16.A total 95...
There is conflicting evidence regarding the prevalence of and risk factors for metabolic-associated fatty liver disease (MAFLD) in patients with inflammatory bowel (IBD). We aimed to determine MAFLD IBD patients.Cross-sectional, case-control study included all consecutive treated at 2 different university hospitals. Controls were subjects randomly selected from general population matched by age, sex, type diabetes status, body mass index a 1:2 ratio. was confirmed controlled attenuation...
Several aspects of the occurrence and management mycotic aneurysm (MA) in patients with infective endocarditis (IE) have not been studied. To determine incidence factors associated MA presence rupture to assess evolution those initially unruptured MA. Prospective multicenter cohort including all definite IE between January 2008 December 2020. Of 4548 cases, 85 (1.9%) developed Forty-six (54.1%) had intracranial 39 (45.9%) extracranial Rupture occurred (45.9%). Patients ruptured higher 1-year...
Abstract Background Outpatient parenteral antibiotic treatment (OPAT) has proven efficacious for treating infective endocarditis (IE). However, the 2001 Infectious Diseases Society of America (IDSA) criteria OPAT in IE are very restrictive. We aimed to compare outcomes with those hospital-based (HBAT). Methods Retrospective analysis data from a multicenter, prospective cohort study 2000 consecutive patients 25 Spanish hospitals (2008–2012) was performed. Results A total 429 (21.5%) received...
Traditional manufacturing methods and materials used to fabricate epidermal electronics for physiological monitoring, transdermal stimulation, therapeutics are complex expensive, preventing their adoption as single-use medical devices. This work describes the fabrication of epidermal, paper-based electronic devices (EPEDs) wearable implantable applications by combining spray-based deposition silanizing agents, highly conductive nanoparticles, encapsulating polymers with laser micromachining....
Abstract Flash glucose monitoring system (FGMS) is an improved subset of continuous with a recognized effectiveness on glycemic control, though validation in patients Liver Cirrhosis (LC) lacking. To evaluate the accuracy FGMS Type 2 Diabetes Mellitus (DM) and LC, prospective, case-control study was performed 61 ambulatory LC DM (LC group, n = 31) or (Control 30). During 14 days, 4 assessments per day self-monitoring blood (SMBG, reference value) followed by scanning. There were 2567 paired...
Prosthetic valve endocarditis caused by Candida spp. (PVE-C) is rare and devastating, with international guidelines based on expert recommendations supporting the combination of surgery subsequent azole treatment.We retrospectively analyzed PVE-C cases collected in Spain France between 2001 2015, a focus management outcome.Forty-six were followed up for median 9 months. Twenty-two patients (48%) had history endocarditis, 30 (65%) nosocomial or healthcare related, (20%) intravenous drug...
Background Some studies have suggested an association between migraine and inflammatory bowel disease. We determined prevalence in a cohort of patients with Methods Patients disease aged 18–65 years were interviewed using ad hoc headache questionnaire. Those who admitted history the last year answered three questions ID-Migraine “yes” to them classified as “definite” those two “probable” migraine. Results 283 Of these, 176 (62.2%) had headache. Fifty-nine (20.8%; 95% CI 16.3–26.0%) met...
Despite having adopted preventive measures, tuberculosis (TB) may still occur in patients with inflammatory bowel disease (IBD) treated anti-tumour necrosis factor (anti-TNF). Data on the causes and characteristics of TB cases this scenario are lacking. Our aim was to describe anti-TNF-treated IBD after publication Spanish prevention guidelines evaluate safety restarting anti-TNF a diagnosis.In multicentre, retrospective, descriptive study, from hospitals were collected. Continuous variables...
Summary Background and Aims Data on the outcomes after switching from adalimumab (ADA) originator to ADA biosimilar are limited. The aim was compare treatment persistence, clinical efficacy, safety in inflammatory bowel disease patients who maintained vs. those switched biosimilar. Methods Patients receiving were remission at standard dose of included. formed non‐switch cohort (NSC), different biosimilars constituted switch (SC). Clinical defined as a Harvey–Bradshaw index ≤4 Crohn's partial...
Os carcinomas epiteliais de cabeça e pescoço (CECP) são neoplasias malignas que afetam estruturas como a cavidade oral, faringe laringe, com alta incidência global impacto significativo na morbidade mortalidade. A etiologia desses tumores é multifatorial, sendo os principais fatores risco o tabagismo, consumo álcool infecção pelo HPV. O diagnóstico precoce difícil devido aos sintomas iniciais vagos limitações nos métodos diagnósticos atuais. tratamento envolve cirurgia, radioterapia...
Abstract Background Inflammatory bowel disease (IBD) patients may have a higher risk of gastrointestinal bleeding during anticoagulant treatment due to mucosal erosions. Millions worldwide receive classic oral anticoagulants or direct-acting (DOACs).The main indication is stroke prophylaxis in atrial fibrillation (AF), with an increasing prevalence older age groups (8.5% the Spanish population over 60 years old).Anticoagulants (especially DOACs) safety data are limited IBD. Our objective was...