José Miguel Montejo
A5102932819- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Antifungal resistance and susceptibility
- Renal Transplantation Outcomes and Treatments
- Neutropenia and Cancer Infections
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Legionella and Acanthamoeba research
- Streptococcal Infections and Treatments
- Transplantation: Methods and Outcomes
- HIV/AIDS Research and Interventions
- Influenza Virus Research Studies
- Cytomegalovirus and herpesvirus research
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- HIV Research and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- T-cell and Retrovirus Studies
- HIV-related health complications and treatments
- Microbial Metabolism and Applications
- Fungal Infections and Studies
- Antimicrobial Peptides and Activities
- Burkholderia infections and melioidosis
- Plant Pathogenic Bacteria Studies
Hospital de Cruces
2003-2022
Instituto de Salud Carlos III
2019-2021
Red Espanola de Investigacion en Patologia Infecciosa
2019-2021
University of the Basque Country
2018
BioCruces Health research Institute
2017
Influenza vaccine effectiveness is not optimal in solid organ transplant recipients (SOTR). We hypothesized that a booster dose might increase it.TRANSGRIPE 1-2 phase 3, randomized, controlled, multicenter, open-label clinical trial. Patients were randomly assigned (1:1 stratified by study site, type of organ, and time since transplantation) to receive 1 (control group) or 2 doses (booster the influenza 5 weeks apart.A total 499 SOTR enrolled. Although seroconversion at 10 did meet...
This report describes the results of six antimicrobial regimens used for treatment brucellosis in an open, randomized study performed over two periods (1980–1983 and 1984–1987). In first period, rifampicin doxycycline were 4 weeks, trimethoprim-sulfamethoxazole 6 months, weeks. During second we streptomycin 2 or 3 weeks together with Comparison showed following: (1) no statistically significant findings revealed when different compared (2) containing yielded more favorable than those...
We aimed to analyze whether the lack of inclusion specific recommendations for management candidemia is an independent risk factor early and overall mortality. Multicenter study adult patients with in 13 hospitals. assessed proportion on whom nine ESCMID IDSA guidelines had been applied, analyzed its impact 455 episodes were documented. Patients who died within first 48 hours excluded. Sixty-two percent received appropriate antifungal treatment. Either echinocandin or amphotericin B therapy...
In contrast with HIV-1, information about drug resistance in HIV-2 is scarce and mainly derived from small series of patients failing antiretroviral therapy. The spectrum changes the reverse transcriptase (RT), protease (PR) integrase (INT) genes was examined individuals enrolled Spanish register. From a total 236 HIV-2-infected registered Spain 1989 to June 2010, 53 PR, 44 RT 8 INT sequences were obtained. Low plasma viraemia precluded collection this most remaining cases. No major...
Whether echinocandins could be used to treat candidemia of a urinary tract source (CUTS) is unknown. We aimed provide current epidemiological information CUTS and compare echinocandin fluconazole treatment on outcomes.A multicenter study adult patients with was conducted in 9 hospitals. defined as concomitant candiduria by the same organism associated significant urological comorbidity. The primary outcome assessed clinical failure (defined 7-day mortality or persistent candidemia) treated...
The diagnosis of invasive aspergillosis (IA) can be problematic in solid organ transplantation (SOT). prognosis greatly varies according to the type transplant, and impact prophylaxis is not well defined.The Diaspersot cohort analyses IA SOT Spain during last 10 years. Proven probable/putative was included.We analysed 126 cases IA. incidences were as follows: 6.5%, 2.9%, 1.8% 0.6% for lung, heart, liver kidney transplantation, respectively. EORTC/MSG criteria confirmed only 49.7% episodes....
To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study onco-hematological PA bloodstream infection (BSI) (2006−2018). The appropriate therapy, monotherapy and inappropriate [IEAT] assessed only Among 1017 BSI episodes, pneumonia source 294 (28.9%). those, 52 (17.7%) were caused by multidrug-resistant (MDR) strain 68...
Abstract The objective of this study was to analyse the mechanisms resistance carbapenems and other extended-spectrum-β-lactams determine genetic relatedness multidrug-resistant Enterobacterales (MDR-E) causing colonization or infection in solid-organ transplantation (SOT) recipients. Prospective cohort kidney (n = 142), liver 98) kidney/pancreas 7) transplant recipients between 2014 2018 seven Spanish hospitals. We included 531 MDR-E isolates from rectal swabs obtained before weekly for 4–6...
Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral therapy. The allograft was removed the second recipient at month due to rejection and immunosuppressors discontinued. To date, 3 years later, this patient remains but asymptomatic. infection recognized retrospectively donor, native Spaniard who had sex partners endemic...
Despite administration of annual influenza vaccination, influenza-associated complications in transplant recipients continue to be an important cause hospitalization and death. Although vaccination has been proven the most effective measure reduce infection after transplantation, are still vulnerable infections, with lower serological responses compared general population. In order assess efficacy safety alternative immunization scheme for solid organ recipients, TRANSGRIPE1-2 Study Group...
Abstract Background Daptomycin plus fosfomycin combination has demonstrated synergistic and bactericidal effect in animal models of methicillin-resistant Staphylococcus aureus bacteremia (MRSAB), but there is lack data humans. Method A randomized (1:1), open-label, clinical trial involving adults with MRSAB was conducted at 18 medical centers Spain. Patients were assigned to receive daptomycin, 10 mg/kg IV daily fosfomycin, 2 g IV/6 hour (combination therapy) or daptomycin mg/kg/24 h...
HIV-2 infection is characterized by low plasma viraemia and slower progression to AIDS in comparison with HIV-1 infection. However, antiretroviral therapy patients less effective often fails provide optimal CD4 recovery.We examined viral tropism persons enrolled the Spanish cohort. Viral was estimated based on V3 sequences obtained from RNA and/or proviral DNA.From a total of 279 individuals recorded national register, 58 belonging 42 were evaluated. X4 viruses recognized 14 (33%). Patients...
Pseudomonas aeruginosa (PA) has historically been one of the major causes severe sepsis and death among neutropenic cancer patients. There a recent increase multidrug-resistant PA (MDRPA) isolates that may determine worse prognosis, particularly in immunosuppressed The aim this study is to establish impact antibiotic resistance on outcome onco-haematological patients with bacteraemia, identify risk factors for MDRPA bacteraemia mortality. This retrospective, observational, multicentre,...
Objective Successful clinical trials are subject to recruitment. Recently, the REJUVENATE trial, a prospective phase 2a open-label, single-arm interventional trial conducted within Innovative Medicines Initiative-supported Combatting Bacterial Resistance in Europe-Carbapenem project, was published, with 85% of recruitment performed Spain. We analysed success this by establishing model practice. Methods A descriptive qualitative study from May 2016 October 2017 at 10 participating Spanish...