A5074814447- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- Clostridium difficile and Clostridium perfringens research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Gut microbiota and health
- Vaccine Coverage and Hesitancy
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Antimicrobial Resistance in Staphylococcus
- Biosensors and Analytical Detection
- COVID-19 epidemiological studies
- Neutropenia and Cancer Infections
- Antibiotics Pharmacokinetics and Efficacy
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Urinary Tract Infections Management
- Bacterial Infections and Vaccines
- Cytomegalovirus and herpesvirus research
- Advanced biosensing and bioanalysis techniques
- Infectious Diseases and Tuberculosis
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
Universidad del Desarrollo
2016-2025
Clínica Alemana
2016-2025
Millennium Initiative for Collaborative Research on Bacterial Resistance
2018-2025
Ministry of Health
2021-2023
Advanced Center for Chronic Diseases
2019-2023
Universidad del Desarrollo del Estado de Puebla
2020-2022
Millennium Science Initiative
2021
Research Center for Integrated Disaster Risk Management
2021
Instituto de Investigaciones en Ciencias de la Salud
2020
Engineering Associates (United States)
2017
Mass vaccination campaigns to prevent coronavirus disease 2019 (Covid-19) are occurring in many countries; estimates of vaccine effectiveness urgently needed support decision making. A countrywide mass campaign with the use an inactivated severe acute respiratory syndrome 2 (SARS-CoV-2) (CoronaVac) was conducted Chile starting on February 2, 2021. We used a prospective national cohort, including participants 16 years age or older who were affiliated public health care system, assess...
Several countries have authorised or begun using a booster vaccine dose against COVID-19. Policy makers urgently need evidence of the effectiveness additional doses and its clinical spectrum for individuals with complete primary immunisation schedules, particularly in where schedule used inactivated SARS-CoV-2 vaccines.Using individual-level data, we evaluated prospective, observational, national-level cohort (aged ≥16 years) affiliated Fondo Nacional de Salud insurance programme Chile, to...
The outbreak of the B.1.1.529 lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Omicron) has caused an unprecedented number Coronavirus Disease 2019 (COVID-19) cases, including pediatric hospital admissions. Policymakers urgently need evidence vaccine effectiveness in children to balance costs and benefits vaccination campaigns, but, date, is sparse. Leveraging a population-based cohort Chile 490,694 aged 3-5 years, we estimated administering two-dose schedule, 28 days...
A multicenter, retrospective study of patients infected with carbapenem-resistant Pseudomonas aeruginosa who were treated ceftolozane/tazobactam was performed. Among 35 patients, pneumonia the most common indication and treatment successful in 26 (74%). Treatment failure observed all cases where isolates demonstrated ceftolozane-tazobactam minimum inhibitory concentrations ≥8 μg/mL.
Abstract In the context of Covid-19 pandemic, development and validation rapid easy-to-perform diagnostic methods are high priority. We compared performance four antigen detection tests for SARS-CoV-2 in respiratory samples. Immunochromatographic assays from RapiGEN, Liming bio, Savant, Bioeasy were evaluated using universal transport medium containing naso-oropharyngeal swabs suspected cases. The accuracy was determined comparison to RT-PCR. A total 111 samples included; 80 RT-PCR positive....
Policymakers urgently need evidence to adequately balance the costs and benefits of mass vaccination against COVID-19 across all age groups, including children adolescents. In this study, we aim assess effectiveness CoronaVac's primary series among adolescents in Chile.We used a large prospective national cohort about two million 6-16 years estimate an inactivated SARS-CoV-2 vaccine (CoronaVac) preventing laboratory-confirmed symptomatic infection (COVID-19), hospitalisation, admission...
The impact of coronavirus disease 2019 (COVID-19) on antimicrobial use (AU) and resistance has not been well evaluated in South America. These data are critical to inform national policies clinical care.
We aimed to assess the rate and predictive factors of bloodstream infection (BSI) due multidrug-resistant (MDR) Pseudomonas aeruginosa in neutropenic cancer patients. performed a multicenter, retrospective cohort study including oncohematological patients with BSI P. conducted across 34 centers 12 countries from January 2006 May 2018. A mixed logistic regression model was used estimate predict multidrug resistance causative pathogens.
Real-Time Reverse-Transcription Polymerase Chain Reaction (RT-PCR) is currently the only recommended diagnostic method for SARS-CoV-2. However, rapid immunoassays SARS-CoV-2 antigen could significantly reduce COVID-19 burden weighing on laboratories around world.We evaluated performance of two fluorescence (FIAs), SOFIA SARS Antigen FIA (Quidel Corporation, San Diego, CA, USA) and STANDARD F Ag (SD Biosensor Inc., Gyeonggi-do, Republic Korea), which use an automated reader. The study used 64...
This large, multicenter, retrospective cohort study including onco-hematological neutropenic patients with Pseudomonas aeruginosa bloodstream infection (PABSI) found that among 1213 episodes, 411 (33%) presented septic shock. The presence of solid tumors (33.3% vs. 20.2%, p < 0.001), a high-risk Multinational Association for Supportive Care in Cancer (MASCC) index score (92.6% 57.4%; pneumonia (38% 19.2% and due to multidrug-resistant P. (MDRPA) (33.8% 21.1%, 0.001) were statistically...
Background. The emergence and dissemination of multidrug-resistant organisms (MDROs) is a global threat. Characterizing the human microbiome among hospitalized patients identifying unique microbial signatures those who acquire MDROs may identify novel infection prevention strategies. Methods. Adult admitted to 5 general medical-surgical floors at 649-bed, tertiary care center in Boston, Massachusetts, were classified according in-hospital antimicrobial exposure MDRO colonization status....
The dissemination of antibiotic-resistant bacteria (ARB) from water used for crop irrigation to vegetables is poorly studied. During a year, five farmer markets in city Central Chile were visited, and 478 vegetable samples (parsleys, corianders, celeries, lettuces, chards, beets) collected. Simultaneously, 32 collected two rivers which are irrigate the produced area. Resistant Enterobacterales isolated identified. Colistin resistance gene mcr-1 extended spectrum β-lactamases (ESBL)...
Objectives: To assess the clinical features and outcomes of Pseudomonas aeruginosa bloodstream infection (PA BSI) in neutropenic patients with hematological malignancies (HM) solid tumors (ST), identify risk factors for 30-day mortality. Methods: We performed a large multicenter, retrospective cohort study including onco-hematological PA BSI conducted across 34 centers 12 countries (January 2006−May 2018). Episodes occurring hematologic were compared to those developing ST. Risk associated...
Abstract Background Accurate estimates of gut colonization with drug-resistant gram-negative bacilli (GNB) are key to combat antimicrobial resistance. Data on best practices assess is scarce, limiting the comparability and feasibility screening efforts. Building upon ongoing projects studying carbapenem-resistant (CR), carbapenemase-producing (CP-CR) extended-spectrum beta-lactamase-producing (ESBL) GNB in Chile, we compared 3 different strategies assessed impact time between swab collection...
In metagenomic sequencing, large volumes of data are obtained with all the genetic information present in a sample, allowing valuable to be about microbial communities. The software and processes necessary obtain quality results have become increasingly complex sophisticated, limiting accessibility biologists who try use them. To facilitate analysis this data, modular reproducible workflow was developed using Nextflow orchestrator named BugBuster. pipeline is easy implement because its...
ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is a major public health menace. The global spread of MRSA characterized by successive waves epidemic clones dominating specific geographical regions. acquisition genes encoding resistance to heavy metals (HMRGs) thought be key feature in the geographic divergence MRSA. However, cause-effect relationship between presence HMRGs and remains clarified. In this study, we assessed role that may have played evolutionary ST5-SCC mec I...
Introduction Breast cancer is the most common malignancy in Americas, and second leading cause of death. Disparities time to treatment can significantly impact patient outcomes typically affect lower socioeconomic individuals and/or ethnic minorities. Our study sought evaluate disparities at three health institutions Chile according their type insurance (public or private). Methods analyzed a database breast patients diagnosed between 2017 2018. Analyses included descriptive statistics...