Isabel Morales
A5006769109- Infective Endocarditis Diagnosis and Management
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Cardiac Valve Diseases and Treatments
- Urinary Tract Infections Management
- Escherichia coli research studies
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Infectious Aortic and Vascular Conditions
- Orthopedic Infections and Treatments
- Central Venous Catheters and Hemodialysis
- Neutropenia and Cancer Infections
- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Clostridium difficile and Clostridium perfringens research
- Higher Education and Sustainability
- Otolaryngology and Infectious Diseases
- Pneumonia and Respiratory Infections
- Education and Teacher Training
- Higher Education Teaching and Evaluation
- Helicobacter pylori-related gastroenterology studies
Hospital Universitario Virgen Macarena
2013-2025
Hospital Universitario Virgen de la Arrixaca
2024
Instituto de Biomedicina de Sevilla
2017-2023
Universidad de Sevilla
2018-2023
Instituto de Salud Carlos III
2013-2020
Red Espanola de Investigacion en Patologia Infecciosa
2013-2020
Centro de Investigación en Red en Enfermedades Cardiovasculares
2018
Research Institute Hospital 12 de Octubre
2016
Universidad Peruana Cayetano Heredia
2012
Instituto Nacional de Perinatología
2010
<h2>Abstract</h2><h3>Objectives</h3> To assess the mortality attributable to infections caused by carbapenem-resistant Enterobacterales (CRE) and investigate effect of clinical management on differences in observed outcomes a multinational matched cohort study. <h3>Methods</h3> A prospective matched-cohorts study (NCT02709408) was performed 50 European hospitals from March 2016 November 2018. The main outcome 30-day with an active post-discharge follow-up when applied. CRE included patients...
<h3>Importance</h3> The consumption of broad-spectrum drugs has increased as a consequence the spread multidrug-resistant (MDR)<i>Escherichia coli</i>. Finding alternatives for these infections is critical, which some neglected may be an option. <h3>Objective</h3> To determine whether fosfomycin noninferior to ceftriaxone or meropenem in targeted treatment bacteremic urinary tract (bUTIs) due MDR<i>E <h3>Design, Setting, and Participants</h3> This multicenter, randomized, pragmatic, open...
Escherichia coli belonging to clonal group ST131 has emerged as a significant contributor infection caused by antibiotic-resistant E. worldwide. We investigated the risk factors for infections and their clinical implications. One thousand seventy-seven isolates were screened molecular methods. Risk separately patients with producing not extended-spectrum β-lactamases (ESBLs) in Seville area, Spain. Multivariate analysis using logistic regression was performed. Patients non-ST131...
We aimed to assess the rate and predictive factors of bloodstream infection (BSI) due multidrug-resistant (MDR) Pseudomonas aeruginosa in neutropenic cancer patients. performed a multicenter, retrospective cohort study including oncohematological patients with BSI P. conducted across 34 centers 12 countries from January 2006 May 2018. A mixed logistic regression model was used estimate predict multidrug resistance causative pathogens.
Introduction Despite the availability of new antibiotics such as daptomycin, methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia continues to be associated with high clinical failure rates. Combination therapy has been proposed an alternative improve outcomes but there is a lack studies. The study aims demonstrate that combination daptomycin plus fosfomycin achieves higher success rates in treatment MRSA than alone. Methods and analysis A multicentre open-label, randomised phase...
The optimal antibiotic regimen for Pseudomonas aeruginosa bacteremia is controversial. Although β-lactam monotherapy common, data to guide the choice between antibiotics are scarce. We aimed compare ceftazidime, carbapenems, and piperacillin-tazobactam as definitive monotherapy.A multinational retrospective study (9 countries, 25 centers) including 767 hospitalized patients with P. treated during 2009-2015. primary outcome was 30-day all-cause mortality. Univariate multivariate,...
Abstract Background Pseudomonas aeruginosa bacteraemia is a common and serious infection. No consensus exists regarding whether definitive combination therapy superior to monotherapy. We aimed evaluate the impact of on mortality. Methods This was multicentre retrospective study (nine countries, 25 centres), including 1277 patients with P. during 2009–15. evaluated association between β-lactam plus aminoglycoside or quinolone versus monotherapy The primary outcome 30 day all-cause Univariate...
Carbapenem-resistant Enterobacterales (CRE) bloodstream infections (BSIs) are a major threat to patients. To date, data on risk factors have been limited, with low internal and external validity. In this multicentre study, for CRE BSI were determined by comparison two control groups: patients carbapenem-susceptible (CSE) BSI, without infection (uninfected patients).
This study was carried out to address potential uncertainties about how point-of-care testing (POCT) improves patients' outcomes in emergency department (ED). The main aim develop and validate a model based on advanced data analytics evaluate POCT's impact ED flow. We built discrete event simulation (DEMS) represent workflow of Spanish ED. Historical from ED, published evidence expert estimates were used support the model. Different scenarios progressive utilization POCT care triaged as...
ABSTRACT Aim To leverage technological advances to propose a more accurate representation of subgingival microbiota diversity and dynamics across health disease, 25 years after the seminal still authoritative contribution Socransky his colleagues. Materials Methods Subgingival plaque from 135 patients (41 healthy, 47 gingivitis, periodontitis) was analysed by V3–V4 16S rRNA sequencing. Sequences were probabilistically assigned unambiguous taxon groups (UTGs) using advanced bioinformatics....
Abstract We investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). prospectively reviewed 83 episodes from 5 centers Spain during April 2011–June 2014 that had optimized clinical management and analyzed relationship between E-test vancomycin, daptomycin, oxacillin, linezolid development complicated bacteremia by using multivariate analysis. Complicated MSSA...
Abstract Background Escherichia coli sequence type 131 (ST131) is a successful clonal group that has dramatically spread during the last decades and considered an important driver for rapid increase of quinolone resistance in E. . Methods Risk factors rectal colonization by ST131 (irrespective ESBL production) were investigated 64 household members (18 colonized) 54 hospital contacts (HC; 10 34 30 index patients with community nosocomial infection due to these organisms, respectively, using...