A5059492845- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Antimicrobial Resistance in Staphylococcus
- Venous Thromboembolism Diagnosis and Management
- Infective Endocarditis Diagnosis and Management
- Respiratory Support and Mechanisms
- COVID-19 and healthcare impacts
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Central Venous Catheters and Hemodialysis
- COVID-19 and Mental Health
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- COVID-19 diagnosis using AI
- Streptococcal Infections and Treatments
- Inflammasome and immune disorders
- Cytomegalovirus and herpesvirus research
- Tracheal and airway disorders
- COVID-19 Impact on Reproduction
- Pediatric Urology and Nephrology Studies
- Actinomycetales infections and treatment
- Autoimmune and Inflammatory Disorders Research
Hospital Universitario 12 De Octubre
2015-2025
Universidad Complutense de Madrid
2016-2025
Centro de Investigación Biomédica en Red
2021-2025
Research Institute Hospital 12 de Octubre
2011-2024
Instituto de Salud Carlos III
2018-2024
Johns Hopkins Hospital
2024
All India Institute of Medical Sciences Rishikesh
2023
All India Institute of Medical Sciences Raipur
2023
Hospital Universitario Ramón y Cajal
2016
Institut de Veille Sanitaire
2011
The clinical characteristics, management, and outcome of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) after solid organ transplant (SOT) remain unknown. We report our preliminary experience with 18 SOT (kidney [44.4%], liver [33.3%], heart [22.2%]) recipients diagnosed COVID-19 March 23, 2020 at a tertiary-care center Madrid. Median age diagnosis was 71.0 ± 12.8 years, the median interval since transplantation 9.3 years. Fever (83.3%)...
The immune response type organized against viral infection is determinant in the prognosis of some infections. This work has aimed to study Th polarization acute COVID-19 and its possible association with outcome through an observational prospective study. Fifty-eight patients were recruited Medicine Department hospital “12 de Octubre,” 55 remaining after losses follow-up. Four groups established according maximum degree disease progression. T-helper cell percentages phenotypes, analyzed by...
Abstract Background The adjuvanted RSV prefusion F protein–based vaccine (RSVPreF3 OA) was efficacious against RSV-related lower respiratory tract disease (RSV-LRTD) in ≥60-years-olds over 1 season. We evaluated efficacy and safety of RSVPreF3 OA dose 2 doses given year apart RSV-LRTD seasons post–dose 1. Methods In this phase 3, blinded trial, ≥60-year-olds were randomized (1:1) to receive or placebo pre–season recipients re-randomized a second (RSV_revaccination group) (RSV_1dose 2;...
Abstract Background Older adults with chronic cardiorespiratory or endocrine/metabolic conditions are at increased risk of respiratory syncytial virus (RSV)-related acute illness (RSV-ARI) and severe disease. In an ongoing, randomized, placebo-controlled, multicountry, phase 3 trial in ≥60-year-old participants, AS01E-adjuvanted RSV prefusion F protein-based vaccine (RSVPreF3 OA) was efficacious against RSV-related lower tract disease (RSV-LRTD), RSV-LRTD, RSV-ARI. We evaluated efficacy...
Background. The influence of acute graft pyelonephritis (AGPN) on outcome in renal transplant recipients still remains controversial. Methods. We retrospectively analysed 189 patients (113 males; mean age: 49.7 ± 13.1 years) undergoing transplantation at the University Hospital 12 de Octubre (Madrid, Spain) from January 2002 to December 2004, with a minimum follow-up 36 months. Factors associated AGPN were assessed by logistic regression analysis. Long-term function was compared according...
BackgroundInformation regarding the incidence and characteristics of COVID-19 pneumonia amongst pregnant women is scarce.MethodsSingle-centre experience with 32 diagnosed between March 5 to April 5, 2020 at Madrid, Spain.FindingsCOVID-19 was in 61·5% (32/52) women. Only 18·7% (6/32) had some underlying condition (mostly asthma). Supplemental oxygen therapy required 18 patients (56·3%), high-flow requirements six (18·7%). Eight (25·0%) fulfilled criteria for acute distress respiratory...
The aim of our study was to elucidate if SARS-CoV-2 viral load on admission, measured by real-time reverse transcriptase–polymerase chain reaction (rRT-PCR) cycle threshold (Ct) value nasopharyngeal samples, a marker disease severity. All hospitalized adult patients with diagnosis infection rRT-PCR performed nasopharingeal sample from March 1 18 in institution were included. population divided according the Ct obtained upon admission high (Ct < 25), intermediate (Ct: 25–30) and low > 30)....
The timing of the development specific adaptive immunity after natural SARS-CoV-2 infection, and its relevance in clinical outcome, has not been characterized depth. Description long-term maintenance both cellular humoral responses elicited by real-world anti-SARS-CoV-2 vaccination is still scarce. Here we aimed to understand optimal protective infection vaccination. We performed an early, longitudinal study S1-, M- N-specific IFN-γ IL-2 T cell anti-S total neutralizing antibodies 88 mild,...
An early analysis of circulating monocytes may be critical for predicting COVID-19 course and its sequelae. In 131 untreated, acute patients at emergency room arrival, showed decreased surface molecule expression, including low HLA-DR, in association with an inflammatory cytokine status limited anti-SARS-CoV-2-specific T cell response. Most these alterations had normalized post-COVID-19 6 months after discharge. Acute transcriptome upregulation anti-inflammatory tissue repair genes such as...
Insufficient data exist about the clinical presentation, short-term, and long-term outcomes of patients with isolated distal deep vein thrombosis (IDDVT), that is, in infrapopliteal veins without proximal extension or pulmonary embolism (PE).To determine characteristics, 1-year IDDVT to compare unadjusted multivariable adjusted analyses who had DVT.This was a multicenter, international cohort study participating sites Registro Informatizado Enfermedad Tromboembólica (RIETE) registry...
The Th1/Th2 balance plays a crucial role in the progression of different pathologies and is determining factor evolution infectious diseases. This work has aimed to evaluate early, or on diagnosis, T-cell compartment response, T-helper subsets anti-SARS-CoV-2 antibody specificity COVID-19 patients classify them according based infection severity. A unicenter, randomized group 146 was divided into four groups accordance with most critical events during course disease. immunophenotype were...
Abstract We conducted a retrospective study of 99 patients with methicillin-suseptible Staphylococcus aureus catheter-related bacteremia in which vancomycin MIC was determined by Etest. High (>1.5 μg/mL) the only independent risk factor for development complicated caused methicillin-susceptible S. (odds ratio 22.9, 95% confidence interval 6.7–78.1).
We analyzed the frequency of cognitive impairment (CI) in deceased COVID-19 patients at a tertiary hospital Spain. Among 477 adult cases who died after admission from March 1 to 31, 2020, 281 had confirmed COVID-19. CI (21.1% dementia and 8.9% mild impairment) was common comorbidity. Subjects with were older, tended live nursing homes, shorter time symptom onset death, rarely admitted ICU, receiving palliative care more often. is frequent comorbidity subjects associated differences care.
Despite the growing number of patients with persistent symptoms after acute SARS-CoV-2 infection, pathophysiology underlying long-COVID is not yet well characterized, and there no established therapy. We performed a deep immune profiling in nine (PSP), before 4-day prednisone course, five post-COVID-19 without (NSP). PSP showed perturbed distribution circulating mononuclear cell populations. Symptoms were accompanied by pro-inflammatory phenotype characterized increased conventional...
A. Garcia‐Reyne, F. López‐Medrano, J.M. Morales, C. García Esteban, I. Martín, Eraña, Y. Meije, Lalueza, Alastruey‐Izquierdo, J.L. Rodríguez‐Tudela, Aguado. Cutaneous infection by Phomopsis longicolla in a renal transplant recipient from Guinea: first report of human this fungus. Transpl Infect Dis 2011: 13: 204–207. All rights reserved Abstract: We the case 72‐year‐old female with nodular lesion distal phalange third left finger produced dematiaceous fungus that was identified as . She...
Objective Patients with coronavirus disease 2019 (COVID‐19) present coagulation abnormalities and thromboembolic events that resemble antiphospholipid syndrome (APS). This work has aimed to study the prevalence of APS‐related antigens, antibodies, immune complexes in patients COVID‐19 their association clinical events. Methods A prospective was conducted on 474 adults severe acute respiratory 2 infection hospitalized two Spanish university hospitals. were evaluated for classic extra‐criteria...
Age and comorbidity are the main determinants of COVID-19 outcome. Shorter leukocyte telomere length (TL), a hallmark biological aging, has been associated with worse outcomes. We sought to determine TL in patients severe requiring hospitalization analyze whether clinical outcomes post-COVID-19 manifestations shorter TL.We analyzed 251 PCR-confirmed COVID-19, hospitalized first months pandemics. determined PBL at admission by quantitative-PCR (qPCR) analysis patients. A healthy cohort from...
The aim of this study was to analyze whether the coronavirus disease 2019 (COVID-19) vaccine reduces mortality in patients with moderate or severe COVID-19 requiring oxygen therapy. A retrospective cohort study, data from 148 hospitals both Spain (111 hospitals) and Argentina (37 hospitals), conducted. We evaluated hospitalized for older than 18 years requirements. Vaccine protection against death assessed through a multivariable logistic regression propensity score matching. also performed...