A5069668726- Pregnancy and preeclampsia studies
- Hematopoietic Stem Cell Transplantation
- Platelet Disorders and Treatments
- Acute Myeloid Leukemia Research
- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Birth, Development, and Health
- CAR-T cell therapy research
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood properties and coagulation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- COVID-19 Impact on Reproduction
- Long-Term Effects of COVID-19
- Venous Thromboembolism Diagnosis and Management
- Inflammasome and immune disorders
- Blood donation and transfusion practices
- Neutropenia and Cancer Infections
- Atrial Fibrillation Management and Outcomes
- Single-cell and spatial transcriptomics
- Retinal and Optic Conditions
- Blood transfusion and management
- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
Hospital Clínic de Barcelona
2018-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019-2025
Universitat de Barcelona
2019-2025
Josep Carreras Leukaemia Research Institute
2020-2022
Leukemia Research Foundation
2022
ORCID
2022
Leuka
2022
Fundación Josep Carreras Contra la Leucemia
2022
JAK2V617F-mutated myeloproliferative neoplasms (MPN) exhibit abnormal proliferation of bone marrow progenitors and increased risk thrombosis, specifically in splanchnic veins (SVT). The contribution the endothelium to development prothrombotic phenotype was explored. Plasma serum samples from JAK2V617F MPN patients with (n=26) or without (n=7) thrombotic debut different treatments, were obtained (n=33). Cultured endothelial cells (ECs) exposed these healthy donors as controls. Changes...
COVID-19 presents a spectrum of signs and symptoms in pregnant women that might resemble preeclampsia. Differentiation between severe preeclampsia is difficult some cases.To study biomarkers endothelial damage, coagulation, innate immune response, angiogenesis pregnancy addition to vitro alterations cells exposed sera from with COVID-19.Plasma samples were obtained infection classified into mild (n=10) or (n=9) normotensive pregnancies as controls patients (n=13). A panel plasmatic was...
Endotheliopathy is a key element in COVID-19 pathophysiology, contributing to both morbidity and mortality. Biomarkers distinguishing different phenotypes from sepsis syndrome remain poorly understood.To characterize circulating biomarkers of endothelial damage clinical disease stages compared with normal volunteers.Patients pneumonia (n = 49) were classified into moderate, severe, or critical (life-threatening) disease. Plasma samples collected within 48 72 h hospitalization analyze...
Angiogenesis and endothelial activation dysfunction have been associated with acute graft-versus-host disease (aGVHD), pointing to the endothelium as a potential target for pharmacological intervention. Defibrotide (DF) is drug an endothelium-protective effect that has approved treatment of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation. Clinical data suggest DF also reduces incidence aGVHD; however, mechanisms DF-mediated aGVHD...
Objective Patients with coronavirus disease 2019 (COVID‐19) present coagulation abnormalities and thromboembolic events that resemble antiphospholipid syndrome (APS). This work has aimed to study the prevalence of APS‐related antigens, antibodies, immune complexes in patients COVID‐19 their association clinical events. Methods A prospective was conducted on 474 adults severe acute respiratory 2 infection hospitalized two Spanish university hospitals. were evaluated for classic extra‐criteria...
Chimeric antigen receptor (CAR)-T cell-based immunotherapy constitutes a revolutionary advance for treatment of relapsed/refractory hematological malignancies. Nevertheless, cytokine release and immune effector cell-associated neurotoxicity syndromes are life-threatening toxicities in which the endothelium could be pathophysiological substrate. Furthermore, differential diagnosis from sepsis, highly incident these patients, is challenging. Suitable laboratory tools determinant their...
Abstract Introduction Our objective was to evaluate the endothelial function profile and complement system in fetuses from preeclamptic pregnancies using ex vivo vitro approaches. Material Methods A total of 66 singleton were prospectively recruited comprising 34 cases preeclampsia 32 normotensive matched for baseline characteristics. In approach, soluble tumor necrosis factor‐a receptor 1 (sTNFR1), vascular cell adhesion molecule‐1 (sVCAM‐1), intercellular (sICAM‐1), Von Willebrand factor...
ABSTRACT Endotheliopathy has been increasingly recognized as a key feature of critical illness. Different diseases and syndromes manifest endothelial dysfunction in their severe forms. Septic syndrome, SARS-CoV-2 disease spectrum cell therapy-associated toxicities represent paradigmatic examples endotheliopathy, intensive care units (ICU). As common features, response to the environment associated with these conditions, cells develop pro-inflammatory pro-thrombotic phenotype, switching its...
Patients with COVID-19 presented an elevated prevalence of antiphospholipid antibodies (aPL) but the relationship thrombosis is controversial. We analysed persistence aPL and their association clinical outcomes during hospitalisation in a cohort patients.We conducted prospective study including consecutive hospitalised patients from Hospital Clínic Barcelona between March 28th April 22nd, 2020. Clinical were thrombosis, intensive care unit (ICU) admission, severe ventilatory failure....
Background Autologous stem cell transplantation (ASCT) remains the standard of care for young multiple myeloma (MM) patients; indeed, at-home ASCT has been positioned as an appropriate therapeutic strategy. However, despite use prophylactic antibiotics, neutropenic fever (NF) and hospital readmissions continue to pose most important limitations in outpatient setting. It is possible that febrile episodes may have a non-infectious etiology, engraftment syndrome could play more significant...
Abstract Graft‐versus‐host disease (GVHD) is a complication of allogeneic haematopoietic cell transplantation. Endothelial injury crucial as pathophysiological substrate for GVHD. GVHD first‐line treatment high‐dose corticosteroids, although some patients are steroid‐refractory. Through the present study, we compared endothelial proteomic profiles in response to serum from steroid‐refractory acute (SR‐aGVHD) and steroid‐sensitive (SS‐aGVHD) patients. Blood samples SR‐aGVHD ( n = 4) SS‐aGVHD...
Current laboratory tests fail to evaluate the hemostatic function of platelets in patients with thrombocytopenia. We investigated use Total Thrombus-Formation Analysis System (T-TAS